Why is the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine in its diphosphorylated form (PMEApp4-) initially a better substrate for polymerases than (2'-deoxy)adenosine 5'-triphosphate (dATP4-/ATP4-)? Considerations on the mechanism of nucleic acid polymerases

Chemical Communications

Volumn , Issue 8, 1999, Pages 743-744

  Sigel, Helmut ^a   Song, Bin ^a   Blindauer, Claudia A ^a   Kapinos, Larisa E ^a   Gregáň, Fridrich ^b   Prónayová, Nadja ^c  

^a UNIVERSITY OF BASEL   (Switzerland)

^b Physics and Informatics   (Slovakia)

^c SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DEOXYADENOSINE TRIPHOSPHATE; ETHER; METAL ION; NUCLEOTIDE DERIVATIVE; RNA POLYMERASE;

ARTICLE; BINDING AFFINITY; ENZYME SUBSTRATE; PHOSPHORYLATION;

EID: 0033590982     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/a901233h     Document Type: Article

References (26)

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9. 2+ in early evolution, see: H. Sigel, Inorg. Chim. Acta 1992, 198-200, 1.
10. L. W. Tari, A. Matte, H. Goldie and L. T. J. Delbaere, Nature Struct. Biol., 1997, 4, 990.
11. For example: H. Pelletier, M. R. Sawaya, W. Wolfle, S. H. Wilson and J. Kraut, Biochemistry, 1996, 35, 12 762; H. Pelletier, Science, 1994, 266, 2025; T. A. Steitz, Nature, 1998, 391, 231.
12. For example: H. Pelletier, M. R. Sawaya, W. Wolfle, S. H. Wilson and J. Kraut, Biochemistry, 1996, 35, 12 762; H. Pelletier, Science, 1994, 266, 2025; T. A. Steitz, Nature, 1998, 391, 231.
13. For example: H. Pelletier, M. R. Sawaya, W. Wolfle, S. H. Wilson and J. Kraut, Biochemistry, 1996, 35, 12 762; H. Pelletier, Science, 1994, 266, 2025; T. A. Steitz, Nature, 1998, 391, 231.
14. H. Sigel, C. P. Da Costa, B. Song and F. Gregáň, submitted for publication.
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16. 11,12c
17. (b) F. Gregáň, V. Kettmann, P. Novomeský and E. Mišiková, Boll. Chim. Farm, 1996, 135, 229;
18. (c) B. Song, S. A. A. Sajadi, F. Gregán, N. Prónayová and H. Sigel, Inorg. Chim. Acta 1998, 273, 101.
19. 3) (the error limits given are three times the standard error of the mean value);
20. (b) S. A. A. Sajadi, B. Song, F. Gregáň and H. Sigel, Inorg. Chem. 1999, 38, 439.
21. Cd(MePP) = 0.17 ± 0.04); details to be published.
22. (a) H. Sigel, D. Chen, N. A. Corfù, F. Gregáň, A. Holý and M. Strašák, Helv. Chim. Acta 1992, 75, 2634;
23. (b) C. A. Blindauer, A. Holý, H. Dvořáková and H. Sigel, J. Biol. Inorg. Chem., 1998, 3, 423.
24. (a) H. Sigel, Coord. Chem. Rev., 1995, 144, 287;
25. (b) H. Sigel, J. Indian Chem. Soc., 1997, 74, 261 (P. Ray Award Lecture).
26. 2+ will be somewhat inhibited by the five-membered chelate formed with the α group and the ether O atom.