메뉴 건너뛰기




Volumn 11, Issue 2, 1997, Pages 163-167

Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP

Author keywords

Acyclic nucleotides; Antitumor activity; In vitro cytotoxicity; Rat T cell lymphomas; T cell modulation

Indexed keywords

2,6 DIAMINOPURINE DERIVATIVE; ADEFOVIR; ANTINEOPLASTIC AGENT; CD4 ANTIGEN; CD8 ANTIGEN;

EID: 0031006322     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (30)

References (26)
  • 1
  • 4
    • 0000002872 scopus 로고
    • Isopolar Phosphorus-Modified Nucleotide Analogues
    • De Clercq E(ed): JAI Press, Inc, Greenwich, CT (USA)
    • Holy A: Isopolar Phosphorus-Modified Nucleotide Analogues In: De Clercq E(ed): Advances in Antiviral Drug Design. vol 1 JAI Press, Inc, Greenwich, CT (USA), pp 179-232, 1994.
    • (1994) Advances in Antiviral Drug Design , vol.1 , pp. 179-232
    • Holy, A.1
  • 7
    • 0024443304 scopus 로고
    • 9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections
    • Gangemi JD, Cozens RM, De Clercq E, Balzarini J, and Hochkeppel HK: 9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections. Antimicrob Agents Chemother 33: 1864-1868, 1989.
    • (1989) Antimicrob Agents Chemother , vol.33 , pp. 1864-1868
    • Gangemi, J.D.1    Cozens, R.M.2    De Clercq, E.3    Balzarini, J.4    Hochkeppel, H.K.5
  • 8
    • 0024791545 scopus 로고
    • 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): A novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo
    • Naesens L, Balzarini J, Rosenberg I, Holy A, and De Clercq E: 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): A novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis 8: 1043-1047, 1989.
    • (1989) Eur J Clin Microbiol Infect Dis , vol.8 , pp. 1043-1047
    • Naesens, L.1    Balzarini, J.2    Rosenberg, I.3    Holy, A.4    De Clercq, E.5
  • 9
    • 0028200457 scopus 로고
    • Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in Hb611 Cells
    • Yokota T, Konno K, Shigeta S, Holy A, Balzarini J and De Clercq E: Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in Hb611 Cells. Antivir Chem. Chemother 5: 57-63, 1994.
    • (1994) Antivir Chem. Chemother , vol.5 , pp. 57-63
    • Yokota, T.1    Konno, K.2    Shigeta, S.3    Holy, A.4    Balzarini, J.5    De Clercq, E.6
  • 11
    • 0029932336 scopus 로고    scopus 로고
    • Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection - A pilot study
    • Arends S, Vanhalteren E, Kamp W, and Schokker J: Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection - A pilot study. Pharm World Sci 18: 30-34, 1996
    • (1996) Pharm World Sci , vol.18 , pp. 30-34
    • Arends, S.1    Vanhalteren, E.2    Kamp, W.3    Schokker, J.4
  • 12
    • 0027819099 scopus 로고
    • Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). III. Rat and mouse carcinomas and sarcomas
    • Praha
    • Otová B, Krenova D, Zidek Z, Holy A, Votruba I and Kren V: Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). III. Rat and mouse carcinomas and sarcomas. Folia Biol. (Praha) 39: 311-314, 1994.
    • (1994) Folia Biol. , vol.39 , pp. 311-314
    • Otová, B.1    Krenova, D.2    Zidek, Z.3    Holy, A.4    Votruba, I.5    Kren, V.6
  • 13
    • 0025371985 scopus 로고
    • Ihe cytostatic effects and mechanism of action of antiviral acyclic nucleotide analogues in L1210 mouse leukemic cells
    • Vesely J, Merta A, Votruba I, Holy A and Rosenberg I: Ihe cytostatic effects and mechanism of action of antiviral acyclic nucleotide analogues in L1210 mouse leukemic cells. Neoplasma 37: 105-110, 1990.
    • (1990) Neoplasma , vol.37 , pp. 105-110
    • Vesely, J.1    Merta, A.2    Votruba, I.3    Holy, A.4    Rosenberg, I.5
  • 14
    • 0027433229 scopus 로고
    • Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). I. Lymphatic leukemia KPH-Lw-I in Lewis rats
    • Praha
    • Otová B, Sladka M, Votruba I, Holy A and Kren V: Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). I. Lymphatic leukemia KPH-Lw-I in Lewis rats. Folia Biol (Praha) 39: 142-152, 1993.
    • (1993) Folia Biol , vol.39 , pp. 142-152
    • Otová, B.1    Sladka, M.2    Votruba, I.3    Holy, A.4    Kren, V.5
  • 15
    • 0027433229 scopus 로고
    • Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats
    • Praha
    • Otová B, Sladka M, Blazek K, Schramlova J, Votruba I and Holy A: Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats. Folia Biol (Praha) 39: 142-149, 1993.
    • (1993) Folia Biol , vol.39 , pp. 142-149
    • Otová, B.1    Sladka, M.2    Blazek, K.3    Schramlova, J.4    Votruba, I.5    Holy, A.6
  • 16
    • 0030918755 scopus 로고    scopus 로고
    • Biological characteristics of spontaneous transplantable T-cell lymphomas in inbred Sprague-Dawley rat
    • in press
    • Otova B, Sladka M, Panczak A and Marinov I: Biological characteristics of spontaneous transplantable T-cell lymphomas in inbred Sprague-Dawley rat. Transplant. Proc. in press, 1997.
    • (1997) Transplant. Proc.
    • Otova, B.1    Sladka, M.2    Panczak, A.3    Marinov, I.4
  • 17
    • 0000446738 scopus 로고
    • Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases
    • Holy A, Rosenberg I, Dvorakova H: Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases. Collect. Czech. Chem. Commun 54: 2190-2210, 1989.
    • (1989) Collect. Czech. Chem. Commun , vol.54 , pp. 2190-2210
    • Holy, A.1    Rosenberg, I.2    Dvorakova, H.3
  • 19
    • 0025643036 scopus 로고
    • The cinical relevance of multidrug resistance
    • Bellamy WT, Dalton WS and Dorr RT: The cinical relevance of multidrug resistance. Cancer Invest. 8: 545-560, 1990.
    • (1990) Cancer Invest. , vol.8 , pp. 545-560
    • Bellamy, W.T.1    Dalton, W.S.2    Dorr, R.T.3
  • 20
    • 0030596710 scopus 로고    scopus 로고
    • Apoptosis provides new targets for chemotherapy
    • Holzman D: Apoptosis provides new targets for chemotherapy. J Nat Cancer Inst 88: 1098-1100, 1996.
    • (1996) J Nat Cancer Inst , vol.88 , pp. 1098-1100
    • Holzman, D.1
  • 22
    • 0025218139 scopus 로고
    • In vivo antitumor activity of 9-[(2-phosphonylmethoxy)ethyl]guanine and related phosphonate nucleotide analogues
    • Rose WC, Crosswell AE, Bronson JJ, and Martin JC: In vivo antitumor activity of 9-[(2-phosphonylmethoxy)ethyl]guanine and related phosphonate nucleotide analogues. J Natl Cancer Inst 82: 510-512, 1990.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 510-512
    • Rose, W.C.1    Crosswell, A.E.2    Bronson, J.J.3    Martin, J.C.4
  • 23
    • 0027366285 scopus 로고
    • Model of acute graf-vs-host-disease in adult (SHR x BN.lx)FI rats and its inhibition by adenine analog
    • Kren V, Otova B, Elleder D, Elleder M, Panczak A and Sladka M: Model of acute graf-vs-host-disease in adult (SHR x BN.lx)FI rats and its inhibition by adenine analog. Transpl Proc 25: 2822-2823, 1993.
    • (1993) Transpl Proc , vol.25 , pp. 2822-2823
    • Kren, V.1    Otova, B.2    Elleder, D.3    Elleder, M.4    Panczak, A.5    Sladka, M.6
  • 24
    • 0028086450 scopus 로고
    • Immunomodulatory properties of 9-(2-phosphono-methoxyethyl)adenine (PMEA)
    • Otova B, Zidek Z, Holy A, Votruba I, Frankova D: Immunomodulatory properties of 9-(2-phosphono-methoxyethyl)adenine (PMEA). Folia Biol Prague 40: 185-192, 1994.
    • (1994) Folia Biol Prague , vol.40 , pp. 185-192
    • Otova, B.1    Zidek, Z.2    Holy, A.3    Votruba, I.4    Frankova, D.5
  • 25
    • 0028169781 scopus 로고
    • 9-(2-phosphonylmethoxyethyl)adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system
    • Villani N, Calio R, Balestra E, Bȧlzarini J, De Clercq E, Fabrizi E, Pemo CF, and Del Gobo V: 9-(2-phosphonylmethoxyethyl)adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system. Antiviral Res 25: 81-89, 1994.
    • (1994) Antiviral Res , vol.25 , pp. 81-89
    • Villani, N.1    Calio, R.2    Balestra, E.3    Balzarini, J.4    De Clercq, E.5    Fabrizi, E.6    Pemo, C.F.7    Del Gobo, V.8
  • 26
    • 0343481234 scopus 로고
    • PMEA has immunomodulatory activity and inhibits reverse transcriptase in the Rauscher murine leukemia virus (RMuLV) model
    • Kunder SC, Black PL, Hall BE, and Ussery MA: PMEA has immunomodulatory activity and inhibits reverse transcriptase in the Rauscher murine leukemia virus (RMuLV) model. Antiviral Res 26: A276, 1995.
    • (1995) Antiviral Res , vol.26
    • Kunder, S.C.1    Black, P.L.2    Hall, B.E.3    Ussery, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.