-
2
-
-
0022450584
-
A novel selective broad-spectrum anti-DNA virus agent
-
Clercq E, Holy A, Rosenberg I, Sakuma T, Baizarini J, and Maudgal PC: A novel selective broad-spectrum anti-DNA virus agent. Nature 25: 464-467, 1986.
-
(1986)
Nature
, vol.25
, pp. 464-467
-
-
Clercq, E.1
Holy, A.2
Rosenberg, I.3
Sakuma, T.4
Baizarini, J.5
Maudgal, P.C.6
-
3
-
-
0025372944
-
Acyclic nucleotide analogs: Synthesis, antiviral activity and inhibition effects on some cellular and virus-encoded enzymes in vitro
-
Holy A, Votruba I, Merta A, Cermy J, Vesely J, Vlach J, Sediva K, Rosenberg I, Otmar M Hrebabecky H, Travnicek M, Vonka V, Snoeck R, and De Clercq E: Acyclic nucleotide analogs: synthesis, antiviral activity and inhibition effects on some cellular and virus-encoded enzymes in vitro. Antiviral Res 13: 295-312, 1990.
-
(1990)
Antiviral Res
, vol.13
, pp. 295-312
-
-
Holy, A.1
Votruba, I.2
Merta, A.3
Cermy, J.4
Vesely, J.5
Vlach, J.6
Sediva, K.7
Rosenberg, I.8
Otmar, M.9
Hrebabecky, H.10
Travnicek, M.11
Vonka, V.12
Snoeck, R.13
De Clercq, E.14
-
4
-
-
0000002872
-
Isopolar Phosphorus-Modified Nucleotide Analogues
-
De Clercq E(ed): JAI Press, Inc, Greenwich, CT (USA)
-
Holy A: Isopolar Phosphorus-Modified Nucleotide Analogues In: De Clercq E(ed): Advances in Antiviral Drug Design. vol 1 JAI Press, Inc, Greenwich, CT (USA), pp 179-232, 1994.
-
(1994)
Advances in Antiviral Drug Design
, vol.1
, pp. 179-232
-
-
Holy, A.1
-
5
-
-
0003303887
-
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent
-
Balzarini J, Naesens L, Herdewijn P, Rosenberg I, Holy A, Powels R, Baba M, Johns DG, and De Clercq E: Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proc Natl Acad Sci USA 86: 332-336, 1989.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 332-336
-
-
Balzarini, J.1
Naesens, L.2
Herdewijn, P.3
Rosenberg, I.4
Holy, A.5
Powels, R.6
Baba, M.7
Johns, D.G.8
De Clercq, E.9
-
6
-
-
0023741036
-
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents
-
Pauwels R, Balzarini J, Schols D, Baba M, Desmyter J, Rosenberg I, Holy A and De Clercq E: Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. Antimicrob. Agents Chemother 32: 1025-1030, 1988.
-
(1988)
Antimicrob. Agents Chemother
, vol.32
, pp. 1025-1030
-
-
Pauwels, R.1
Balzarini, J.2
Schols, D.3
Baba, M.4
Desmyter, J.5
Rosenberg, I.6
Holy, A.7
De Clercq, E.8
-
7
-
-
0024443304
-
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections
-
Gangemi JD, Cozens RM, De Clercq E, Balzarini J, and Hochkeppel HK: 9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections. Antimicrob Agents Chemother 33: 1864-1868, 1989.
-
(1989)
Antimicrob Agents Chemother
, vol.33
, pp. 1864-1868
-
-
Gangemi, J.D.1
Cozens, R.M.2
De Clercq, E.3
Balzarini, J.4
Hochkeppel, H.K.5
-
8
-
-
0024791545
-
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): A novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo
-
Naesens L, Balzarini J, Rosenberg I, Holy A, and De Clercq E: 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): A novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis 8: 1043-1047, 1989.
-
(1989)
Eur J Clin Microbiol Infect Dis
, vol.8
, pp. 1043-1047
-
-
Naesens, L.1
Balzarini, J.2
Rosenberg, I.3
Holy, A.4
De Clercq, E.5
-
9
-
-
0028200457
-
Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in Hb611 Cells
-
Yokota T, Konno K, Shigeta S, Holy A, Balzarini J and De Clercq E: Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in Hb611 Cells. Antivir Chem. Chemother 5: 57-63, 1994.
-
(1994)
Antivir Chem. Chemother
, vol.5
, pp. 57-63
-
-
Yokota, T.1
Konno, K.2
Shigeta, S.3
Holy, A.4
Balzarini, J.5
De Clercq, E.6
-
10
-
-
0028792567
-
Clinical Pharmacokinetics of Adefovir in human immunodeficiency virus type 1-infected patients
-
Cundy KC, BarditchCrovo PA, Walker RE, Collier AC, Ebeling D, Toole J, and Jafee HS: Clinical Pharmacokinetics of Adefovir in human immunodeficiency virus type 1-infected patients. Antimicrob. Agents Chemother 39: 2401-2405, 1995
-
(1995)
Antimicrob. Agents Chemother
, vol.39
, pp. 2401-2405
-
-
Cundy, K.C.1
BarditchCrovo, P.A.2
Walker, R.E.3
Collier, A.C.4
Ebeling, D.5
Toole, J.6
Jafee, H.S.7
-
11
-
-
0029932336
-
Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection - A pilot study
-
Arends S, Vanhalteren E, Kamp W, and Schokker J: Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection - A pilot study. Pharm World Sci 18: 30-34, 1996
-
(1996)
Pharm World Sci
, vol.18
, pp. 30-34
-
-
Arends, S.1
Vanhalteren, E.2
Kamp, W.3
Schokker, J.4
-
12
-
-
0027819099
-
Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). III. Rat and mouse carcinomas and sarcomas
-
Praha
-
Otová B, Krenova D, Zidek Z, Holy A, Votruba I and Kren V: Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). III. Rat and mouse carcinomas and sarcomas. Folia Biol. (Praha) 39: 311-314, 1994.
-
(1994)
Folia Biol.
, vol.39
, pp. 311-314
-
-
Otová, B.1
Krenova, D.2
Zidek, Z.3
Holy, A.4
Votruba, I.5
Kren, V.6
-
13
-
-
0025371985
-
Ihe cytostatic effects and mechanism of action of antiviral acyclic nucleotide analogues in L1210 mouse leukemic cells
-
Vesely J, Merta A, Votruba I, Holy A and Rosenberg I: Ihe cytostatic effects and mechanism of action of antiviral acyclic nucleotide analogues in L1210 mouse leukemic cells. Neoplasma 37: 105-110, 1990.
-
(1990)
Neoplasma
, vol.37
, pp. 105-110
-
-
Vesely, J.1
Merta, A.2
Votruba, I.3
Holy, A.4
Rosenberg, I.5
-
14
-
-
0027433229
-
Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). I. Lymphatic leukemia KPH-Lw-I in Lewis rats
-
Praha
-
Otová B, Sladka M, Votruba I, Holy A and Kren V: Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). I. Lymphatic leukemia KPH-Lw-I in Lewis rats. Folia Biol (Praha) 39: 142-152, 1993.
-
(1993)
Folia Biol
, vol.39
, pp. 142-152
-
-
Otová, B.1
Sladka, M.2
Votruba, I.3
Holy, A.4
Kren, V.5
-
15
-
-
0027433229
-
Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats
-
Praha
-
Otová B, Sladka M, Blazek K, Schramlova J, Votruba I and Holy A: Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats. Folia Biol (Praha) 39: 142-149, 1993.
-
(1993)
Folia Biol
, vol.39
, pp. 142-149
-
-
Otová, B.1
Sladka, M.2
Blazek, K.3
Schramlova, J.4
Votruba, I.5
Holy, A.6
-
16
-
-
0030918755
-
Biological characteristics of spontaneous transplantable T-cell lymphomas in inbred Sprague-Dawley rat
-
in press
-
Otova B, Sladka M, Panczak A and Marinov I: Biological characteristics of spontaneous transplantable T-cell lymphomas in inbred Sprague-Dawley rat. Transplant. Proc. in press, 1997.
-
(1997)
Transplant. Proc.
-
-
Otova, B.1
Sladka, M.2
Panczak, A.3
Marinov, I.4
-
17
-
-
0000446738
-
Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases
-
Holy A, Rosenberg I, Dvorakova H: Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases. Collect. Czech. Chem. Commun 54: 2190-2210, 1989.
-
(1989)
Collect. Czech. Chem. Commun
, vol.54
, pp. 2190-2210
-
-
Holy, A.1
Rosenberg, I.2
Dvorakova, H.3
-
18
-
-
0027761916
-
Mitotic index and cell proliferation kinetics for identification of antineoplastic activity
-
Rojas E, Herrera LA, Sordo M, Gonsebatt ME, Montero R, Rodriguez R and Ostrosky-Wegman P: Mitotic index and cell proliferation kinetics for identification of antineoplastic activity. Anti-Cancer Drugs 4: 637-640, 1993.
-
(1993)
Anti-Cancer Drugs
, vol.4
, pp. 637-640
-
-
Rojas, E.1
Herrera, L.A.2
Sordo, M.3
Gonsebatt, M.E.4
Montero, R.5
Rodriguez, R.6
Ostrosky-Wegman, P.7
-
20
-
-
0030596710
-
Apoptosis provides new targets for chemotherapy
-
Holzman D: Apoptosis provides new targets for chemotherapy. J Nat Cancer Inst 88: 1098-1100, 1996.
-
(1996)
J Nat Cancer Inst
, vol.88
, pp. 1098-1100
-
-
Holzman, D.1
-
21
-
-
0029941879
-
-
Kramata P, Votruba I, Otova B and Holy A: Different inhibitory properties of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases α, δ, and ε Molecular Pharmacol 49: 1005-1011, 1996.
-
(1996)
Different Inhibitory Properties of Acyclic Phosphonomethoxyalkyl Nucleotide Analogs Toward DNA Polymerases α, δ, and ε Molecular Pharmacol
, vol.49
, pp. 1005-1011
-
-
Kramata, P.1
Votruba, I.2
Otova, B.3
Holy, A.4
-
22
-
-
0025218139
-
In vivo antitumor activity of 9-[(2-phosphonylmethoxy)ethyl]guanine and related phosphonate nucleotide analogues
-
Rose WC, Crosswell AE, Bronson JJ, and Martin JC: In vivo antitumor activity of 9-[(2-phosphonylmethoxy)ethyl]guanine and related phosphonate nucleotide analogues. J Natl Cancer Inst 82: 510-512, 1990.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 510-512
-
-
Rose, W.C.1
Crosswell, A.E.2
Bronson, J.J.3
Martin, J.C.4
-
23
-
-
0027366285
-
Model of acute graf-vs-host-disease in adult (SHR x BN.lx)FI rats and its inhibition by adenine analog
-
Kren V, Otova B, Elleder D, Elleder M, Panczak A and Sladka M: Model of acute graf-vs-host-disease in adult (SHR x BN.lx)FI rats and its inhibition by adenine analog. Transpl Proc 25: 2822-2823, 1993.
-
(1993)
Transpl Proc
, vol.25
, pp. 2822-2823
-
-
Kren, V.1
Otova, B.2
Elleder, D.3
Elleder, M.4
Panczak, A.5
Sladka, M.6
-
24
-
-
0028086450
-
Immunomodulatory properties of 9-(2-phosphono-methoxyethyl)adenine (PMEA)
-
Otova B, Zidek Z, Holy A, Votruba I, Frankova D: Immunomodulatory properties of 9-(2-phosphono-methoxyethyl)adenine (PMEA). Folia Biol Prague 40: 185-192, 1994.
-
(1994)
Folia Biol Prague
, vol.40
, pp. 185-192
-
-
Otova, B.1
Zidek, Z.2
Holy, A.3
Votruba, I.4
Frankova, D.5
-
25
-
-
0028169781
-
9-(2-phosphonylmethoxyethyl)adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system
-
Villani N, Calio R, Balestra E, Bȧlzarini J, De Clercq E, Fabrizi E, Pemo CF, and Del Gobo V: 9-(2-phosphonylmethoxyethyl)adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system. Antiviral Res 25: 81-89, 1994.
-
(1994)
Antiviral Res
, vol.25
, pp. 81-89
-
-
Villani, N.1
Calio, R.2
Balestra, E.3
Balzarini, J.4
De Clercq, E.5
Fabrizi, E.6
Pemo, C.F.7
Del Gobo, V.8
-
26
-
-
0343481234
-
PMEA has immunomodulatory activity and inhibits reverse transcriptase in the Rauscher murine leukemia virus (RMuLV) model
-
Kunder SC, Black PL, Hall BE, and Ussery MA: PMEA has immunomodulatory activity and inhibits reverse transcriptase in the Rauscher murine leukemia virus (RMuLV) model. Antiviral Res 26: A276, 1995.
-
(1995)
Antiviral Res
, vol.26
-
-
Kunder, S.C.1
Black, P.L.2
Hall, B.E.3
Ussery, M.A.4
|