Hyperactivation of p21ras and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

Journal of Experimental Medicine

Volumn 194, Issue 1, 2001, Pages 57-69

  Ingram, David A ^a   Hiatt, Kelly ^a   King, Alastair J ^a,d   Fisher, Lucy ^a   Shivakumar, Rama ^a   Derstine, Christina ^a   Wenning, Mary Jo ^a   Diaz, Bruce ^c   Travers, Jeffrey B ^a   Hood, Antoinette ^a   Marshall, Mark ^c   Williams, David A ^a,b   Clapp, D Wade ^a,e  

^a INDIANA UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cross talk; Neurofibromatosis type 1; P13 K; Pak; Rac

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROFIBROMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P21; RAC PROTEIN; RAS PROTEIN; RHO FACTOR;

ADOLESCENT; ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL PROLIFERATION; DISEASE MODEL; ENZYME ACTIVATION; GENETICS; GENOTYPE; MAST CELL; MOUSE; NEUROFIBROMATOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BONE MARROW CELLS; CELL DIVISION; CHROMONES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HEMATOPOIETIC SYSTEM; HETEROZYGOTE; MAP KINASE KINASE KINASE 1; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NERVE TISSUE PROTEINS; NEUROFIBROMIN 1; ORGAN SPECIFICITY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); RAC GTP-BINDING PROTEINS; STEM CELL FACTOR;

EID: 0035796397     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.1.57     Document Type: Article

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