Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

Journal of Experimental Medicine

Volumn 191, Issue 1, 2000, Pages 181-187

  Ingram, David A ^a   Yang, Feng Chun ^a   Travers, Jeffrey B ^a   Wenning, Mary Jo ^a   Hiatt, Kelly ^a   New, Sheryl ^a   Hood, Antoinette ^a   Shannon, Kevin ^b   Williams, David A ^a   Clapp, D Wade ^a,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

c kit; Heterozygous; Mast cell; Neurofibromatosis; Tumor suppressor

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROFIBROMIN; PROTEIN TYROSINE KINASE; RAS PROTEIN; STEM CELL FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL FATE; CONTROLLED STUDY; GENE INACTIVATION; GENE LOCUS; GENE LOSS; HAPLOTYPE; HETEROZYGOTE; MAST CELL; MELANOCYTE; MOUSE; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL DIVISION; CELL SURVIVAL; GENES, NEUROFIBROMATOSIS 1; MAST CELLS; MELANOCYTES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTO-ONCOGENE PROTEINS C-KIT; STEM CELL FACTOR;

EID: 0034598363     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.1.181     Document Type: Article

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