CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: A possible role for ERK activation

Brain Research

Volumn 893, Issue 1-2, 2001, Pages 95-103

  Pulliam, Lynn ^a,b   Irwin, Ian ^c   Kusdra, Leonard ^b   Rempel, Hans ^b   Flitter, William D ^c   Garland, William A ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c EVOTEC AG   (Germany)

Author keywords

AIDS dementia; gp120; Macrophage; MAP kinase; Quinolinic acid; TNF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CPI 1189; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROPROTECTIVE AGENT; QUINOLINIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMNESIA; APOPTOSIS; ARTICLE; BRAIN PROTECTION; CELL DEATH; CHRONIC INFLAMMATION; CLINICAL FEATURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; GLIOSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MACROPHAGE; MICROGLIA; MOTOR DYSFUNCTION; NERVE DEGENERATION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SUPERNATANT;

AIDS DEMENTIA COMPLEX; APOPTOSIS; BRAIN; BUTANES; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; HIV ENVELOPE PROTEIN GP120; HUMANS; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NECROSIS; NEURONS; NEUROTOXINS; NF-KAPPA B; NITROGEN OXIDES; PHOSPHORYLATION; PROTEIN TRANSPORT; QUINOLINIC ACID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035793999     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03293-5     Document Type: Article

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