CPI-1189 inhibits interleukin 1β-induced p38-mitogen-activated protein kinase phosphorylation: An explanation for its neuroprotective properties?

Neuroscience Letters

Volumn 281, Issue 2-3, 2000, Pages 179-182

  Hensley, Kenneth ^a   Robinson, Kent A ^a   Pye, Quentin N ^a   Floyd, Robert A ^a   Cheng, Iona ^b   Garland, William A ^b   Irwin, Ian ^b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b EVOTEC AG   (Germany)

Author keywords

Astrocyte; Interleukin; p38 Mitogen activated protein kinase; Phosphorylation

Indexed keywords

BENZAMIDE DERIVATIVE; CPI 1189; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; INFLAMMATION; NERVE DEGENERATION; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BLOTTING, WESTERN; BUTANES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; ENZYME INHIBITORS; INTERLEUKIN-1; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034001250     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)00861-2     Document Type: Article

References (20)

1. Badger A.M., Bradbeer J.N., Votta B., Lee J.C., Adams J.L., Griswold D.E. Pharmacological profile of SB203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 179:1996;1453-1461.
2. Bhat N.R., Zhang P., Lee J.C., Hogan E.L. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α-gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18:1998;1633-1641.
3. Bjugstad D.B., Flitter W.D., Garland W.A., Su G.C., Arendash G.W. Preventive actions of a synthetic antioxidant in a novel animal model of AIDS dementia. Brain Res. 795:1998;349-357.
4. Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., Lee J.C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:1995;229-233.
5. Da Silva J., Pierrat B., Mary J-L., Lesslauer W. Blockade of p38 mitogen-activated protein kinase pathway inhibits inucible nitric oxide synthase expression in mouse astrocytes. J. Biol. Chem. 272:1997;28373-28380.
6. Guan Z., Buckman S.Y., Pentland A.P., Templeton D.J., Morrison A.R. Induction of cyclooxygenase-2 by the activated MEKK1→SEK1/MKK4→p38 mitogen-activated protein kinase pathway. J. Biol. Chem. 273:1998;12901-12908.
7. 2: role in cell survival following oxidant injury. J. Biol. Chem. 271:1996;4138-4142.
8. Han J., Jiang Y., Li Z., Kravchenko V.V., Ulevitch R.J. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature. 386:1997;296-299.
9. Hensley K., Floyd R.A., Zheng N-Y., Nael R., Robinson K.A., Nguyen X., Pye Q.N., Stewart C.A., Geddes J., Markesbery W.R., Patel E., Johnson Gail V.W., Bing G. p38 Kinase is activated in the Alzheimer's disease brain. J. Neurochem. 72:1999;2053-2058.
10. Hensley K., Carney J.M., Stewart C.A., Tabatabaie T., Pye Q., Floyd R.A. Nitrone-based free radical traps as neuroprotective agents in cerebral ischemia and other pathologies. In Neuroprotective Agents and Cerebral Ischemia. Int. Rev. Neurobiol. 40:1997;299-317.
11. Kummer J.L., Rao P.K., Heidenreich K.A. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J. Biol. Chem. 272:1997;20490-20494.
12. Lee J.C., Laydon J.T., McDonnell P.C., Gallagher T.F., Kumar S., Green D., McNulty D., Blumenthal M.J., Heys J.R., Landvatter S.W., Strickler J.E., McLaughlin M.M., Siemens I.R., Fisher S.M., Livi G.P., White J.R., Adams J.L., Young P.R. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 373:1994;739-746.
13. Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., Davis R.J. Proinflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:1996;7420-7426.
14. Ridley S.H., Sarsfield S.J., Lee J.C., Bigg H.F., Cawston Y.E., Taylor D.J., DeWitt D.L., Saklatvala J. Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase. J. Immunol. 158:1997;3165-3173.
15. Robinson K.A., Stewart C.A., Pye Q.N., Nguyen X., Kenney L., Salsman S., Floyd R.A., Hensley K. Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture. J. Neurosci. Res. 55:1999;724-732.
16. Wang Z., Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science. 272:1996;1347-1349.
17. Wilson K.P., McCaffrey P.G., Hsiao K., Pazhanisamy S., Galullo V., Bemis G.W., Fitzgibbon M.J., Caron P.R., Murcko M.A., Su M.S.S. The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. Chem. Biol. 4:1997;423-431.
18. Xia Z., Dickens M., Gaingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
19. Xing J., Kornhauser J.M., Zia K., Thielle E.A., Greenberg M.E. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kianse pathways to stimulate CREB serine 133 phosphorylation. Mol. Cell. Biol. 18:1998;1946-1955.
20. Young P.R., McLaughlin M.M., Kumar S., Kassis S., Doyle M.L., McNulty D., Gallagher T.F., Fisher S., McDonnell P.C., Carr S.A., Huddleston M.J., Seibel G., Porter T.G., Liv G.P., Adams J.L., Lee J.C. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind to the ATP site. J. Biol. Chem. 272:1997;12116-12121.