CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-α infusion model for AIDS dementia complex

Journal of NeuroVirology

Volumn 6, Issue 6, 2000, Pages 478-491

  Bjugstad, K B ^a   Flitter, W D ^a   Garland, W A ^a   Philpot, R M ^a   Kirstein, C L ^a   Arendash, G W ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Antioxidant; Apoptosis; Inflammation; Tumor necrosis factor

Indexed keywords

4 ACETAMIDO N TERT BUTYLBENZAMIDE; ANTIOXIDANT; BENZAMIDE DERIVATIVE; CPI 1189; GLIAL FIBRILLARY ACIDIC PROTEIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTOSIS; BLOOD BRAIN BARRIER; CELL PROTECTION; CONTROLLED STUDY; CORPUS CALLOSUM; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INFUSION; MALE; NONHUMAN; OXIDATIVE STRESS; PREVENTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; SEPTUM PELLUCIDUM;

EID: 0034487245     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550280009091948     Document Type: Article

References (55)

1. Programmed cell death in brains of HIV-1 positive AIDS and pre-AIDS patients
2. Severe toxoplasmic ventriculomenin-goencephalomyelitis in two AIDS patients following treatment of cerebral toxoplasmic granuloma
3. Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia
4. Reduced basal ganglia volume in HIV-1-associated dementia: Results from a quantitative neuroimaging
5. Human astrocytes proliferate in response to tumor necrosis factor alpha
6. The anti-apoptosis bcl-2 proto-oncogene is preferentially expressed in limbic structure of the primate brain
7. Preventative actions of a synthetic antioxidant in a novel animal model of AIDS dementia
8. Patterns of cerebral atrophy in HIV-1-infected individuals: Results of a quantitative MRI analysis
9. Apoptosis in the brain: Physiology and pathology
10. Effect of the spintrapping compound N-tert-butyl-α-phenylnitrone on protein oxidation and life span
11. Tumor necrosis factor α induces expression of human immunodeficiency virus in a chronically infected T-cell clone
12. Morphometry, histopathology, and tomography of cerebral atrophy in the acquired immunodefiency syndrome
13. Clinical-neuropathologic correlation in HIV-associated dementia
14. Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia
15. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
16. Oxidative stress and apoptosis in HIV infection: A role for plant derived metabolites with synergistic antioxidant activity
17. CPI-1189 inhibits interleukin 1β-induced p39-mitogen activated protein kinase phosphorylation: An explanation for its neuroprotective properties
18. Regional brain atrophy in HIV-1 infection: Association with specific neuropsychological test performance
19. Cerebral ventricular enlargement relates to neuropsychological measure in unselected AIDS patients
20. Neuropsychological characterization of the AIDS dementia complex and rationalization of a test battery
21. Spectrum of human immunodeficiency virus-associated neocortical damage
22. Improved method for the estimation of hydroxyl free radical levels in vivo based on liquid chromatography with electrochemical detection
23. Activation of microglial cells by β-amyloid protein and interferon-γ
24. TNF-α and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte culture and glioblastoma cells
25. The AIDS dementia complex: I. Clinical features
26. The AIDS dementia complex: II. Neuropathology
27. The role of tumor necrosis factor-α in acquired immunodeficiency syndrome
28. Effects of interleukin-1β and tumor necrosis factor-α on the expression of glial fibrillary acidic protein and transferrin in cultured astrocytes
29. The role of oxidative stress in HIV disease
30. Human cytomegalo-virus-stimulates peripheral blood mononuclear cells to induce HIV-1 replication via tumor necrosis factor-α-mediated mechanisms
31. Blood-brain barrier abnormalities in acquired immunodeficiency syndrome: Immunohistochemical localization of serum proteins in post-mortem brain
32. Evidence of apoptotic cell death in HIV encephalitis
33. Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood-brain barrier
34. TNF-α transgenic and knockout models of CNS inflammation and degeneration
35. Intrablood-brain barrier syntheses of HTLV-III specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex
36. Evidence of serum-protein leakage across the blood-brain barrier in the acquired immunodeficiency syndrome
37. Antioxidant treatment with phenyl-α-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats
38. Tumor necrosis factor-α, microglia and astrocytes in AIDS dementia complex
39. Cytokine cytotoxicity against oligodendrocytes: Apoptosis induced by lymphotoxin
40. Proliferation of astrocytes in vitro in response to cytokines: A primary role for tumor necrosis factor
41. Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with a down-regulation of glial fibrillary acidic protein mRNA
42. Intranigral iron infusions in the rat. Acute elevations in nigral lipid peroxidation and striatal dopaminergic markers with ensuing nigral degeneration
43. Apoptosis induced by HIV-infection of the central nervous system
44. DNA damage induced by tumour necrosis factor-α in L929 cells is mediated by mitochondrial oxygen radical formation
45. Detection of salicylate and its hydroxylated adducts 2,3- and 2,5-dihydroxybenzoic acids as possible indices for in vivo hydroxyl radical formation in combination with catechol- and indoleamines and cerebrospinal fluid and brain tissue
46. Human immunodeficiency virus (HIV) leukoencephalopathy and the microcirculation
47. The brain's immune system
48. Localization of HIV-1 in human brain using PCR/in situ hybridization and immunocytochemistry
49. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: Protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA
50. Tumor necrosis factor: An updated review of its biology
51. Neuropsychological characterization of the AIDS dementia complex: A preliminary report
52. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia
53. Cellular localization of human immunodeficiency virus infection within the brains of acquired immunodeficiency syndrome patients
54. In vitro evidence for a dual role of tumor necrosis factor alpha in human immunodeficiency virus type 1 encephalopathy