Pemphigus - Paradigm of autoantibody-mediated autoimmunity

Skin Pharmacology and Applied Skin Physiology

Volumn 14, Issue 6, 2001, Pages 408-418

  Hertl, Michael ^a   Veldman, Christian ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Adhesion; Autoantibody; Autoimmunity; Desmoglein; Immunosuppression

Indexed keywords

AUTOANTIBODY; GLUCOCORTICOID; IMMUNOGLOBULIN G1; IMMUNOSUPPRESSIVE AGENT; POLYCLONAL ANTIBODY;

ACANTHOLYSIS; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; AUTOIMMUNITY; BODY FLUID; CELL ADHESION; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPIDERMIS; EROSION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; KERATINOCYTE; MUCOSA; NONHUMAN; PATHOGENICITY; PEMPHIGUS; PEMPHIGUS FOLIACEUS; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; REMISSION; REVIEW; WEIGHT REDUCTION;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; HUMANS; PEMPHIGUS;

EID: 0035742033     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056375     Document Type: Review

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8. A newly characterized HLA-DQβ allele associated with pemphigus vulgaris
9. Pemphigus vulgaris autoantibody response is linked to HLA-DQB1*0503 in Pakistani patients
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12. The distribution of pemphigus vulgaris IgG subclasses and reactivity with desmoglein 3 and 1 in pemphigus patients and first-degree relatives
13. Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: A model for autoimmunity
14. Immunoglobulin G subclass distribution of anti-intercellular substance antibodies in pemphigus
15. IgG, IgA and IgE autoantibodies against the ectodomain of desmoglein 3 in active pemphigus vulgaris
16. Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein 1
17. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease
18. Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg 3) produced by baculovirus
19. Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic
20. Immunoreactivity against intracellular domains of desmogleins in pemphigus
21. Pemphigus IgG, but not bullous pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4,5-triphosphate in DJM-1 cells, a squamous cell carcinoma line
22. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells: A mechanism for the loss of epidermal cohesion and blister formation
23. Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line
24. Pemphigus sera recognize conformationally sensitive epitopes in the amino-terminal region of desmoglein-1
25. Pemphigus vulgaris and pemphigus foliaceus sera show an inversely graded binding pattern to extracellular regions of desmosomes in different layers of human epidermis
26. Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients
27. Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein 1
28. Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles
29. A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocollins
30. Identification of a new antibody population directed against a desmosomal plaque antigen in pemphigus vulgaris and pemphigus foliaceus
31. Pemphigus vulgaris antibody identifies pemphaxin: A novel keratinocyte annexin-like molecule binding acetylcholine
32. Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by pemphigus vulgaris autoimmunity
33. Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus
34. Autoantibody formation against a 190-kD antigen of the desmosomal plaque in pemphigus foliaceus
35. Characterization of paraneoplastic pemphigus autoantigens by immunoblot analysis
36. Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with parancoplastic pemphigus and cause acantholysis in vivo in neonatal mice
37. A case of paraneoplastic pemphigus with antidesmoglein 1 antibodies as determined by immunoblotting
38. Parancoplatic pemphigus: An autoimmune mucocutaneous disease associated with neoplasia
39. Human autoantibodies against desmoplakins in paraneoplastic pemphigus
40. The members of the plakin family of proteins recognized by paraneoplastic pemphigus antibodies include periplakin
41. Envoplakin and periplakin, the paraneoplastic pemphigus antigens, are also recognized by pemphigus foliaceus autoantibodies
42. Human antibodies against HD1/plectin in paraneoplastic pemphigus
43. Human desmocollin 1 (Dsc1) is an autoantigen for the subcorneal pustular dermatosis type of IgA pemphigus
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45. Identification of desmoglein 1 as autoantigen in a patient with intraepidermal neutrophilic IgA dermatosis type of IgA pemphigus
46. IgA autoantibodies bind to pemphigus vulgaris antigen in a case of intraepidermal neutrophilic IgA dermatosis
47. Demonstration of an adhering-junction molecule (plakoglobin) in the autoantigens of pemphigus foliaceus and pemphigus vulgaris
48. Recognition of pemphigus antigens in drug-induced pemphigus vulgaris and pemphigus foliaceus
49. Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions
50. Analysis of the T cells that are potentially involved in autoantibody production in pemphigus vulgaris
51. Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals
52. Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: Charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris
53. Development and characterization of desmoglein 3-specific T cells from patients with pemphigus vulgaris
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55. HLA class II restriction of autoreactive T cell responses in pemphigus vulgaris and potential application for a specific immunotherapy
56. Desmoglein 1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem)
57. In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: Interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis
58. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
59. Explanation for localization of blisters in pemphigus patients
60. Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1
61. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus