Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1

Journal of Investigative Dermatology

Volumn 110, Issue 1, 1998, Pages 76-78

  Shirakata, Y ^a   Amagai, M ^a   Hanakawa, Y ^a   Nishikawa, T ^a   Hashimoto, K ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoimmune; Cadherin; Cell adhesion

Indexed keywords

DESMOGLEIN;

ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; BLISTER; CELL ADHESION; DESMOSOME; EPIDERMIS CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MOUTH MUCOSA; MUCOSA CELL; PEMPHIGUS FOLIACEUS; PRIORITY JOURNAL; SQUAMOUS EPITHELIUM; TISSUE SPECIFICITY;

EID: 0031934294     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00085.x     Document Type: Chapter

References (17)

1. M. Amagai Pemphigus: autoimmunity to epidermal cell adhesion molecules Adv Dermatol 11 1996 319 352
2. M. Amagai T. Hashimoto N. Shimizu T. Nishikawa Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus J Clin Invest 94 1994 59 67
3. M. Amagai T. Hashimoto K.J. Green N. Shimizu T. Nishikawa Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus J Invest Dermatol 104 1995 895 901
4. M. Amagai P.J. Koch T. Nishikawa J.R. Stanley Pemphigus vulgaris antigen (Desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients J Invest Dermatol 106 1996 351 355
5. G.J. Anhalt R.S. Labib J.J. Voorhees T.F. Beals L.A. Diaz Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease N Engl J Med 306 1982 1189 1196
6. J. Arnemann K.H. Sullivan A.I. Magee I.A. King R.S. Buxton Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis J Cell Sci 104 1993 741 750
7. M. Dmochowski T. Hashimoto M. Amagai The extracellular aminoterminal domain of bovine desmoglein I (Dsg1) is recognized only by certain pemphigus foliaceus sera, whereas its intracellular domain is recognized by both pemphigus vulgaris and pemphigus foliaceus sera J Invest Dermatol 103 1994 173 177
8. T. Hashimoto M.M. Ogawa A. Konohana T. Nishikawa Detection of pemphigus vulgaris and pemphigus foliaceus antigens by immunoblot analysis using different antigen sources J Invest Dermatol 94 1990 327 331
9. T. Hashimoto M. Amagai K. Watanabe A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocollins J Invest Dermatol 104 1995 541 544
10. D. Ioannides P. Hytiroglou R.G. Phelps J.C. Bystryn Regional variation in the expression of pemphigus foliaceus, pemphigus erythematosus, and pemphigus vulgaris antigens in human skin J Invest Dermatol 96 1991 159 161
11. A.J. North M.A. Chidgey J.P. Clarke W.G. Bardsley D.R. Garrod Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis Proc Natl Acad Sci USA 93 1996 7701 7705
12. E.A. Rivitti J.A. Sanches L.M. Miyauchi S.A. Sampaio V. Aoki L.A. Diaz Pemphigus foliaceus autoantibodies bind both epidermis and squamous mucosal epithelium, but tissue injury is detected only in the epidermis J Am Acad Dermatol 31 1994 954 958
13. B. Rock R.S. Labib L.A. Diaz Monovalent Fab’ immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal Balb/c mice J Clin Invest 85 1990 296 299
14. N. Rubinstein J.R. Stanley Pemphigus foliaceus antibodies and a monoclonal antibody to desmoglein I demonstrate stratified squamous epithelial-specific epitopes of desmosomes Am J Dermatopathol 9 1987 510 514
15. S. Schafer P.J. Koch W.W. Franke Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins Exp Cell Res 211 1994 391 399
16. J.R. Stanley Pemphigus T.B. Fitzpatrick A.Z. Eisen K. Wolff I.M. Freedberg K.F. Austen Dermatology in General Medicine 1993 MacGraw-Hill New York 606 614
17. M.J. Viela T. Hashimoto T. Nishikawa A.J. North D.R. Garrod A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen J Cell Sci 10 1995 1743 1750