Binding of autoantibodies is not restricted to desmosomes in pemphigus vulgaris: Comparison of 14 cases of pemphigus vulgaris and 10 cases of pemphigus foliaceus studied by Western immunoblot and immunoelectron microscopy

Archives of Dermatological Research

Volumn 288, Issue 7, 1996, Pages 343-352

  Bédane, Christophe ^a,b,c   Prost, Catherine ^c,d   Thomine, Elisabeth ^e   Intrator, Lilianne ^f   Joly, Pascal ^e   Caux, Frederic ^c   Blecker, Myriam ^c   Bernard, Philippe ^a,b   Leboutet, Marie Jo ^a   Tron, Francois ^e   Lauret, Philippe ^e   Bonnetblanc, Jean Marie ^a,b   Dubertret, Louis ^c  

^a DUPUYTREN UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF LIMOGES   (France)

^c SAINT LOUIS HOSPITAL   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e HÔPITAL CHARLES NICOLLE   (France)

^f HENRI MONDOR HOSPITAL   (France)

Author keywords

Adherens junctions; Desmosomes; Immunoelectron microscopy; Pemphigus

Indexed keywords

AUTOANTIBODY; CADHERIN; DESMOGLEIN; PEROXIDASE;

ADULT; AGED; ANTIGEN BINDING; ARTICLE; CATTLE; CELL ADHESION; CELL MEMBRANE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DESMOSOME; EPIDERMIS; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNE COMPLEX DEPOSITION; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; KERATINOCYTE; MALE; PEMPHIGUS FOLIACEUS; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; TONGUE; ULTRASTRUCTURE;

EID: 8944225496     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02507101     Document Type: Article

References (39)

1. Hashimoto K, Lever WF (1967) An electron microscopic study on pemphigus vulgaris of the mouth and the skin with special reference to the intercellular cement. J Invest Dermatol 48: 540-552
2. Wilgram GF, Caulfield JB, Madgic EB (1964) An electron microscopic study of acantholysis and dyskeratosis in pemphigus foliaceus. J Invest Dermatol 43:287-299
3. Stanley JR, Yarr M, Hawley-Nelson et al (1982) Pemphigus antibodies identify a cell surface glycoprotein synthesized by human and mouse keratinocytes. J Clin Invest 70:281-288
4. Stanley JR, Koulu L, Thivolet C et al (1984) Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies. J Clin Invest 74:313-320
5. Eyre RW, Stanley JR (1987) Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients. J Exp Med 165:1719-1724
6. Stanley JR; Koulu L, Klaus-Kovtun V et al (1986) A monoclonal antibody to the desmosomal glycoprotein desmoglein I binds the same polypeptide as human autoantibodies in pemphigus foliaceus. J Immunol 136:1227-1230
7. Amagai M, Klaus-Kovtun V, Stanley JR (1991) Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell-cell adhesion. Cell 67:869-877
8. Koch PJ, Walsh MJ, Schmelz M et al (1990) Identification of desmoglein, a constitutive desmosomal glycoprotein as a member of the cadherin family of cell adhesion molecules. Eur J Cell Biol 53:1-12
9. Chorzelski T, Biczysko W, Dabrowski J et al (1968) Ultrastructural localization of pemphigus autoantibodies. J Invest Dermatol 50:36
10. Wolff K, Schreiner E (1971) Ultrastructural localization of pemphigus autoantibodies within the epidermis. Nature 229: 59-61
11. Hönigsman H, Holubar K, Wolff K et al (1975) Immunochemical localization of in vivo bound immunoglobulins in pemphigus vulgaris epidermis. Arch Dermatol Res 254:113-120
12. Gorbsky G, Cohen S, Steinberg MS (1983) Desmosomal antigens are not recognized by the majority of pemphigus autoimmune sera. J Invest Dermatol 80:475-480
13. Prost C, Intrator L, Roujeau JC et al (1989) An antigenic extract of bovine tongue for analysis of both pemphigus vulgaris and bullous pemphigoid antibodies by immunoblotting (abstract). J Invest Dermatol 92:502
14. Jones JC, Yokoo KM, Goldman RD (1986) Further analysis of pemphigus autoantibodies and their use in studies on the heterogeneity, structure and function of desmosomes. J Cell Biol 102:1109-1117
15. Bernard P, Prost C, Lecerf V et al (1989) Studies of cicatricial pemphigoid autoantibodies using direct immunoelectron microscopy and immunoblot analysis. J Invest Dermatol 94:84-89
16. Prost C, Dubertret L, Fosse M et al (1984) A routine immunoelectron microscopic technique for localization an autoantibody on epidermal basement membrane. Br J Dermatol 110: 1-7
17. Bédane C, Prost C, Bernard P et al (1991) Cicatricial pemphigoid antigen differs from bullous pemphigoid antigen by its exclusive extracellular localization: a study by indirect immunoelectron microscopy. J Invest Dermatol 97:3-9
18. Hashimoto T, Konohana A, Nishikawa T (1991) Immunoblot assay as an aid to the diagnosis of unclassified forms of pemphigus. Arch Dermatol 127:843-847
19. Arnemann J, Sullivan KH, Magee Al et al (1993) Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis. J Cell Sci 104:741-750
20. Arnemann J, Spurr NK, Buxton RS (1992) The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the gene coding for the other two known desmogleins, assigned to chromosome 18. Hum Genet 89:347-350
21. Amagai M, Karpati S, Prussick R et al (1992) Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic. J Clin Invest 90: 919-926
22. Rappersberger K, Roos N, Stanley JR (1992) Immunomorphologic and biochemical identification of the pemphigus foliaceus autoantigen within desmosomes. J Invest Dermatol 99:323-330
23. Jones JC, Yokoo KM, Goldman RD (1986) A cell surface desmosome-associated component: identification of a tissue-specific cell adhesion molecule. Proc Natl Acad Sci USA 83: 7282-7286
24. Akiyama M, Hashimoto T, Sugiura M et al (1991) Ultrastructural localization of pemphigus vulgaris and pemphigus foliaceus antigens in cultured human squamous carcinoma cells. Br J Dermatol 125:233-237
25. Karpati S, Amagai M, Prussick R et al (1993) Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes. J Cell Biol 122:409-415
26. Shimizu H, Ishiko A, Masunaga T et al (1993) Autoantibodies of patients with pemphigus vulgaris and pemphigus foliaceus hind exclusively to desmosomes (abstract). J Dermatol Sci 6: 50
27. Stanley JR, Yuspa SH (1983) Specific epidermal protein markers are modulated during calcium-induced terminal differentiation. J Cell Biol 96:1809-1814
28. ++ concentration. J Invest Dermatol 89:167-171
29. Amagai M, Karpati S, Klaus-Kovtun V, Udey MC, Stanley J (1994) Extracellular domain of pemphigus vulgaris antigen (desmoglein 3) mediates weak homophilic adhesion. J Invest Dermatol 102:402-408
30. Milner Y, Sagi E, Timberg R et al (1989) Binding modes of IgG from pemphigus auto-immune sera onto guinea keratinocyte and the fate of bound IsGs. J Cell Physiol 139: 441-454
31. Kaiser HW, Ness W, Jungblut I et al (1993) Adherens junction: demonstration in human epidermis. J Invest Dermatol 100: 180-185
32. Takeishi M (1990) Cadherins: a molecular family important in selective cell-cell adhesion. Annu Rev Bioehem 59:237-252
33. Cowin P, Kapprell HP, Francke WW et al (1986) Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell 46:1063-1073
34. Hand JL, McNiven MA, Williams CL, Pittelkow MR (1993) E Cadherin expression and localization in melanocyte-keratinocyte co-culture (abstract). J Invest Dermatol 100:507
35. Wilgram GF, Caulfield JB, Lever WF (1961) An electron microscopic study of acantholysis in pemphigus vulgaris. J Invest Dermatol 36:373-382
36. Hu CH, Michel B, Schiltz JR (1978) Epidermal acantholysis induced in vitro by pemphigus autoantibody. Am J Pathol 90: 345-351
37. Iwatsuki K, Sugaya K, Takigawa M (1993) Dynamic expression of pemphigus and desmosomal antigens by cultured keratinocytes. Br J Dermatol 128: 16-22
38. Burge SM, Wilson CL, Dean D et al (1993) An immunohistological study of desmosomal components in pemphigus. Br J Dermatol 128:363-370
39. Weelock MJ, Jensen PJ (1992) Regulation of keratinocyte intercellular junction organization and epithelial morphogenesis by E cadherin. J Cell Biol 117:415-425