Detection of antigen-specific B cells in patients with pemphigus vulgaris by enzyme-linked immunospot assay: Requirement of T cell collaboration for autoantibody production

Journal of Investigative Dermatology

Volumn 114, Issue 1, 2000, Pages 88-94

  Nishifuji, Koji ^a,b   Amagai, Masayuki ^a   Kuwana, Masataka ^a   Iwasaki, Toshiro ^b   Nishikawa, Takeji ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Autoimmunity; Desmoglein; T cell B cell colloboration

Indexed keywords

AUTOANTIBODY; DESMOGLEIN; HLA ANTIBODY;

ADULT; AGED; ANALYTIC METHOD; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LEUKOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MALE; MEMORY CELL; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; QUANTITATIVE ASSAY;

EID: 0034120496     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00840.x     Document Type: Article

References (34)

1. Ahmed AR, Yunis EJ, Khatri K, Wagner R, Notani G, Awdeh Z, Alper CA: Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci USA 87:7658-7662, 1990
2. Ahmed AR, Wagner R, Khatri K, Notani G, Awdeh Z, Alper CA, Yunis EJ: Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci USA 88:5056-5061, 1991
3. Amagai M: Pemphigus: autoimmunity to epidermal cell adhesion molecules. Adv Dermatol 11:319-352, 1996
4. Amagai M, Klaus-Kovtum V, Stanley JR: Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67:869-877, 1991
5. Amagai M, Karpati S, Prussick R, Klaus-Kovtun V, Stanley JR: Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic. J Clin Invest 90:919-926, 1992
6. Amagai M, Hashimoto T, Shimizu N, Nishikawa T: Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J Clin Invest 94:59-67, 1994
7. Amagai M, Koch PJ, Nishikawa T, Stanley JR: Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients. J Invest Dermatol 106:351-355, 1996
8. Amagai M, Nishikawa T, Nousari HC, Anhalt GJ, Hashimoto T: Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. J Clin Invest 102:775-782, 1998
9. Amagai M, Komai A, Hashimoto T, et al: Usefulness of enzyme-linked immunosorbent assay (ELISA) using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus. Br J Dermatol 140:351-357, 1999a.
10. Amagai M, Tsunoda K, Zillikens D, Nagai T, Nishikawa T: The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile. J Am Acad Dermatol 40:167-170, 1999b
11. Bocher WO, Herzog-Hauff S, Herr W, Heermann K, Gerken G, Meyer zum Buschenfelde KH, Lohr HF: Regulation of the neutralizing anti-hepatitis B surface (HBs) antibody response in vitro in HBs vaccine recipients and patients with acute or chronic hepatitis B virus (HBV) infection. Clin Exp Immunol 105:52-58, 1996
12. Ding X, Aoki V, Mascaro JM, Lopez-Swiderski A, Diaz LA, Fairley JA: Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles. J Invest Dermatol 109:592-596, 1997
13. Gunnarsson I, Ronnelid J, Huang YH, Nilsson RB, Lundberg I, Klareskog L: Association between ongoing anti-C1q antibody production in peripheral blood and proliferative nephritis in patients with active systemic lupus erythematosus. Br J Rheumatol 36:32-37, 1997
14. Hertl M, Amagai M, Sundaram H, Stanley JR, Ishii K, Katz SI: Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals. J Invest Dermatol 110:62-66, 1998a
15. Hertl M, Karr RW, Amagai M, Katz SI: Heterogeneous MHC II restriction pattern of autoreactive desmoglein 3 specific T cell responses in pemphigus vulgaris patients and normals. J Invest Dermatol 110:388-392, 1998b
16. Inoko H, Ota M: PCR-RFLP. In: Hui KM, Bidwell JL (eds). Handbook of HLA Typing Techniques. Boca Raton, FL: CRC Press, 1993, pp. 9-70
17. Ishii K, Amagai M, Hall RP, et al: Characterization of autoantibodies in pemphigus using antigen-specific ELISAs with baculovirus expressed recombinant desmogleins. J Immunol 159:2010-2017, 1997
18. Kuwana M, Medsger TA, Wright TM: T and B cell collaboration is essential for the autoantibody response to DNA topoisomerase I in systemic sclerosis. J Immunol 155:2703-2714, 1995a
19. Kuwana M, Medsger TA, Wright TM: T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors. J Clin Invest 96:586-596, 1995b
20. Kuwana M, Kaburaki J, Ikeda Y: Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. J Clin Invest 102:1393-1402, 1998
21. Lenz P, Amagai M, Volc-Platzer B, Stingl G, Kirnbauer R: Desmoglein3 - ELISA. A pemphigus vulgaris-specific diagnostic tool. Arch Dermatol 135:143-148, 1999
22. Lin MS, Swartz SJ, Lopez A, et al: Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris. J Clin Invest 99:31-40, 1997
23. Miyagawa S, Higashimine I, Iida T, Yamashina Y, Fukumoto T, Shirai T: HLA-DRB1*04 and DRB1*14 alleles are associated with susceptibility to pemphigus among Japanese. J Invest Dermatol 109:615-618, 1997
24. Nakamura M, Burastero SE, Ueki Y, Larrick JW, Notkins AL, Casali P: Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. J Immunol 141:4165-4172, 1988
25. Nakamura M, Ishibashi H, Matui M, Shimoda S, Hayashida K, Koike K, Niho Y: Peripheral B lymphocyte repertoire to mitochondrial antigen in primary biliary cirrhosis - positive correlation between the disease activity and the frequency of circulating B lymphocytes specific for pyruvate dehydrogenase complex. Autoimmunity 21:253-262, 1995
26. Niizeki H, Inoko H, Narimatsu H, et al: HLA class II antigens are associated with Japanese pemphigus patients. Hum Immunol 31:246-250, 1991
27. Niizeki H, Inoko H, Mizuki N, Inamoto N, Watababe K, Hashimoto T, Nishikawa T: HLA-DQA1-DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method. Tissue Antigens 44:248-251, 1994
28. Proby CM, Ohta T, Suzuki H, et al: Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris. Br J Dermatol, in press
29. Protti MP, Manfredi AA, Straub C, Howard JF, Conti-Tronconi BM: CD4+ T cell response to the human acetylcholine receptor a subunit in myasthenia gravis. J Immunol 144:1276-1281, 1990
30. Ronnelid J, Huang YH, Norrlander T, Rogberg S, Nilsson B, Gustafsson R, Klareskog L: Short-term kinetics of the humoral anti-C1q response in SLE using the ELISPOT method: fast decline in preduction in response to steroids. Scand J Immunol 40:243-250, 1994
31. Sinha AA, Brautbar C, Szafer F, et al: A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. Science 239:1026-1029, 1988
32. Stanley JR: Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid, bullous diseases due to defective epidermal cell adhesion. Adv Immunol 53:291-325, 1993
33. Wucherpfennig KW, Yu B, Bhol K, Monos DS, Argyris E, Karr RW, Ahmed AR, Strominger JL: Structural basis for major histocompatibility complex (MHC) -linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proc Natl Acad Sci U S A 92:11935-11939, 1995
34. Zubler RH, Perrin LH, Doucet A, Zhang X, Huang YP, Miescher PA: Frequencies of HIV-reactive B cells in seropositive and seronegative individuals. Clin Exp Immunol 87:31-36, 1991