Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions

Journal of Clinical Investigation

Volumn 106, Issue 12, 2000, Pages 1467-1479

  Nguyen, V T ^a   Ndoye, A ^a   Shultz, L D ^a   Pittelkow, M R ^a   Grando, S A ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CELL ANTIGEN; CHOLINERGIC RECEPTOR; DESMOGLEIN; DESMOGLEIN 1; DESMOGLEIN 3; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; HUMAN; IMMUNOPATHOGENESIS; KERATINOCYTE; MOUSE; NEWBORN; NONHUMAN; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; SKIN FIBROBLAST;

EID: 0034519478     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10305     Document Type: Article

References (66)

1. The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Pemphigus vulgaris and foliaceus patients develop antibodies against keratinocyte cholinergic receptors
2. Pemphigus antibodies identify a cell surface glycoprotein synthesized by human and mouse keratinocytes
3. Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies
4. Pemphigus and pemphigoid as paradigms of organ-specific, autoantibody-mediated diseases
5. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
6. A monoclonal antibody to the desmosomal glycoprotein desmoglein I binds the same polypeptide as human autoantibodies in pemphigus foliaceus
7. Demonstration of an adhering-junction molecule (plakoglobin) in the autoantigens of pemphigus foliaceus and pemphigus vulgaris
8. Cadherins and blistering skin diseases
9. Adhesion molecules. I. Keratinocyte-keratinocyte interactions; cadherins and pemphigus
10. Defective cell-cell adhesion in the epidermis
11. Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid, bullous diseases due to defective epidermal cell adhesion
12. Immunofluorescence and immunoblot studies on the reactivity of pemphigus vulgaris and pemphigus foliaceus sera with desmoglein 3 and desmoglein 1
13. Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients
14. N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma
15. Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation
16. Vesicle formation and follicular root sheath separation in mice homozygous for deleterious alleles at the balding (bal) locus
17. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
18. Postnatal lethality, of P-Cadherin/Desmoglein 3 double knockout mice: Demonstration of a cooperative effect of these cell adhesion molecules in tissue homeostasis of stratified squamous epithelia
19. Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic
20. Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes
21. Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus
22. Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus
23. Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice
24. Novel human α9 acetylcholine receptor regulating keratinocyte adhesion is targeted by pemphigus vulgaris autoimmunity
25. The calcium-sensitive epitope of pemphigus foliaceus antigen is present on a murine tryptic fragment and constitutes a major antigenic region for human autoantibodies
26. Identification of pemphigus vulgaris antigen extracted from normal human epidermis and comparison with pemphigus foliaceus antigen
27. Detection of pemphigus vulgaris and pemphigus foliaceus antigens by immunoblot analysis using different antigen sources
28. Immunoblot assay as an aid to the diagnoses of unclassified cases of pemphigus
29. The analysis of IgG subclasses of anti-intercellular antibodies in pemphigus by an immunoblot technique
30. Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1
31. Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles
32. Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
33. Immunofluorescence tests. Clinical significance of sera and skin in bullous diseases
34. Activation of keratinocyte muscarinic acetylcholine receptors reverses pemphigus acantholysis
35. Pemphigus vulgaris antibody identifies pemphaxin: A novel keratinocyte annexin-like molecule binding acetylcholine
36. Pemphigus foliaceus sera recognize an N-terminal fragment of bovine desmoglein 1
37. The clinical phenotype of pemphigus is defined by the antidesmoglein autoantibody profile
38. Desmoglein 3-ELISA: A pemphigus vulgaris-specific diagnostic tool
39. Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus
40. Production of epidermal acantholysis in normal human skin in vitro by the IgG fraction from pemphigus serum
41. Methylprednisolone inhibits pemphigus acantholysis in skin cultures
42. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease
43. Inhibition of neutrophil adherence to antibody by dapsone: A possible therapeutic mechanism of dapsone in the treatment of IgA dermatoses
44. The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic
45. An electron microscopic study of acantholysis in pemphigus vulgaris
46. Noninfectious vesicobullous and vesicopustular diseases
47. Pemphigus: Diseases of antidesmosomal autoimmunity
48. Explanation for localization of blisters in pemphigus patients
49. Ricerche sull'influenza esercitata da sieri di soggetti sani o affetti da pemfigo su pelle umana normale e pemfigosa coltivata "in vitro"
50. Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase
51. Demonstration of pemphigus antibodies on the cell surface of murine epidermal cell monolayers and their internalization
52. Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining
53. Autoradiography using storage phosphor technology
54. 32P-labeled cDNA probes
55. Characterization of a 45 kD epidermal tryptic peptide recognized by pemphigus foliaceus sera
56. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins
57. Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell detachment induced by pemphigus IgG in cultured keratinocytes: Involvement of protein kinase C
58. Pemphigus vulgaris-IgG causes a rapid depletion of desmoglein 3 (Dsg3) from the triton X-100 soluble pools, leading to the formation of Dsg3-depleted desmosomes in a human squamous carcinoma cell line, DJM-1 cells
59. A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes
60. Pemphigus vulgaris IgG regulates expression of urokinase receptor and junctional proteins that may contribute to acantholysis
61. Annexins: From structure to function
62. Biological functions of keratinocyte cholinergic receptors
63. Ditected actin polymerization is the driving force for epithelial cell-cell adhesion
64. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
65. 2+ pump, cause Darier disease
66. Autoimmunity to keratinocyte acetylcholine receptors in pemphigus