Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris

Journal of Clinical Investigation

Volumn 99, Issue 1, 1997, Pages 31-40

  Lin, Mong Shang ^a,d   Swartz, Sue J ^a   Lopez, Argelia ^a   Ding, Xiang ^a   Fernandez Vina, Marcelo A ^c   Stastny, Peter ^c   Fairley, Janet A ^a,b   Diaz, Luis A ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d Midwest Athletes Against Childhood Cancer Inc   (United States)

Author keywords

cytokines; desmoglein 3; MHC II restriction; pemphigus vulgaris; T lymphocytes

Indexed keywords

AUTOANTIBODY; DESMOGLEIN; HLA DQ ANTIGEN; HLA DR3 ANTIGEN; HYBRID PROTEIN;

ADULT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL ADHESION; CELL INTERACTION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MEMORY CELL; PEMPHIGUS VULGARIS; PRIORITY JOURNAL;

EID: 0031028992     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119130     Document Type: Article

References (53)

1. Lever, W.F. 1965. Pemphigus vulgaris. In Pemphigus and Pemphigoid. W.F. Lever, editor. C. Charles Thomas, Springfield.
2. Beutner, E.H., and R.E. Jordon. 1964. Demonstration of skin antibodies in sera of patients with pemphigus vulgaris by indirect immunofluorescent staining. Proc. Soc. Exp. Biol. Med. 117:505-510.
3. Stanley, J.R., L. Koulu, and C. Thivolet. 1984. Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies. J. Clin. Invest. 74:313-320.
4. Civatte, A. 1943. Diagnostic histopathologique de la dermatite polymorphe douloureseou maladie de During-Brocq. Ann. Dermatol. Syph. 3:1-30.
5. Jones, C.C., R.G. Hamilton, and R.E. Jordon. 1988. Subclass distribution of human IgG autoantibodies in pemphigus. J. Clin. Immunol. 8:43-49.
6. Bhol, K.A., A. Mohimen, and A.R. Ahmed. 1994. Correlation of subclasses of IgG with disease activity in pemphigus vulgaris. Dermatology (Basel). 189(Suppl. 1):85-89.
7. Bhol, K., K. Natarajan, N. Nagarwalla, A. Mohimen, V. Aoki, and A.R. Ahmed. 1995. Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity. Proc. Natl. Acad. Sci. USA. 92:5239-5243.
8. Anhalt, G.J., R.S. Labib, J.J. Voorhees, T.F. Beals, and L.A. Diaz. 1982. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N. Engl. J. Med. 306:1189-1196.
9. Amagai, M., V. Klaus-Kovtun, and J.R. Stanley. 1991. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 67:869-877.
10. Buxton, R.S., and A.I. Magee. 1992. Structure and interactions of desmosomal and other cadherins. Semin. Cell. Biol. 3:157-167.
11. Karpati, S., M. Amagai, R. Prussick, K. Cehrs, and J.R. Stanley. 1993. Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes. J. Cell Biol. 122:409-415.
12. Amagai, M., S. Karpati, V. Klaus-Kovtun, M.C. Udey, and J.R. Stanley. 1994. Extracellular domain of pemphigus vulgaris antigen (desmoglein 3) mediates weak homophilic adhesion. J. Invest. Dermatol. 102:402-408.
13. Amagai, M., S. Karpati, R. Prussick, V. Klaus-Kovtun, and J.R. Stanley. 1992. Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic. J. Clin. Invest. 90:919-926.
14. Amagai, M., T. Hashimoto, N. Shimizu, and T. Nishikawa. 1994. Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J. Clin. Invest. 94:59-67.
15. Allegretta, M., J.A. Nicklas, S. Siram, and R.J. Albertini. 1990. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science (Wash. DC). 247:718-721.
16. Melms, A., S. Chrestel, B.C.G. Schalke, H. Wekerle, A. Mauron, M. Ballivet, and T. Barkas. 1989. Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene. J. Clin. Invest. 83:785-790.
17. Mullins, R.J., S.B. Cohen, L.M. Webb, Y. Chernajovsky, C.M. Dayan, M. Londei, and M. Deldmann. 1995. Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines. J. Clin. Invest. 96:30-37.
18. Coffman, R.L., B.W.P. Seymour, D.A. Lebman, D.D. Hiraki, J.A. Christiansen, B. Shrader, H.M. Cherwinski, H.F.J. Savelkoul, F.D. Finkelman, M.W. Bond, and T.R. Mosmann. 1988. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102:5-28.
19. Bartlett, W.C., A. Michael, J. McCann, D. Yuan, E. Claassen, and R.J. Noelle. 1989. Cognate interactions between helper T cells and B cells. II. Dissection of cognate help by using class II-restricted, antigen-specific, IL-2-dependent helper T cell clone. J. Immunol. 143:1745-1754.
20. Hamano, T., Y. Asano, T. Iwasaki, T. Yamasaki, K. Hase, and E. Kakishita. 1992. Direct interaction between an antigen-specific B cell clones and an MHC class II-reactive helper T cell clone. J. Leukocyte Biol. 52:89-96.
21. Kupfer, A., T.R. Mosmann, and H. Kupfer. 1991. Polarized expression of cytokines in cell conjugates of helper cells and splenic B cells. Proc. Natl. Acad. Sci. USA. 88:775-779.
22. Stevens, T.L., A. Bossie, V.M. Sanders, R. Fernadez-Botran, R.L. Coffman, T.R. Mosmann, and E.S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature (Lond.). 334:255-258.
23. Aarden, L.A., E.R. De Groof, O.L. Schapp, and P.M. Lansdorp. 1987. Production of hybridoma growth factor by human monocytes. Eur. J. Immunol. 17:1411-1416.
24. Smith, G.E., G. Ju, B.L. Ericson, J. Mosohera, H.W. Lahm, R. Chizzonite, and M.D. Summers. 1985. Modification and secretion of human interleukin 2 produced in insect cells by a baculovirus expression vector. Proc. Natl. Acad. Sci. USA. 82:8404-8408.
25. Liu, Z., L.A. Diaz, S.J. Swartz, J.L. Troy, J.A. Fairley, and G.J. Giudice. 1995. Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid. J. Immunol. 155: 5449-5454.
26. Liu, Z., L.A. Diaz, L. Haas, and G.J. Giudice. 1992. CDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. J. Biol. Chem. 267:15829-15835.
27. Vila, L.M., H.M. Haftel, H.S. Park, M.-S. Lin, N.C. Romzek, S.M. Hanash, and J. Holoshitz. 1995. Expansion of mycobacterium-reactive γδ T cells by a subset of memory helper T cells. Infect. Immunol. 63:1211-1217.
28. Indiveri, F., J. Huddlestone, M.A. Pellegrino, and S. Ferrone. 1980. Isolation of human T lymphocytes: comparison between wool filtration and rosetting with neuraminidase (VCN) and 2-aminoethylisothiouronium bromide (AET)-treated sheep red blood cells. J. Immunol. Methods. 34:107-115.
29. Miltenyi, S., W. Muller, W. Wiechel, and A. Radbruch. 1989. High gradient magnetic cell separation with MACS. Cytometry. 11:231-238.
30. Taswell, C. 1981. Limiting dilution assays for the determination of immuno-competent cell frequencies. I. Data analysis. J. Immunol. 126:1614-1619.
31. Ohlin, M., L. Danielsson, R. Carlsson, and A.K. Borrebaeck. 1989. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes. Immunology. 66:485-490.
32. Del Prete, G., M. De Carli, F. Almerigogna, C.K. Daniel, M.M. D'Elios, G. Zancuoghi, F. Vinante, G. Pizzolo, and S. Romagnani. 1995. Preferential expression of CD30 by human CD4+ T cells producing Th2-type cytokines. FASEB (Fed. Am. Soc. Exp. Biol.) J. 9:81-86.
33. Chen, Y.-W., M.-S. Lin, and K.A. Vora. 1992. B cell differentiation. I. Development and functional analysis of murine B cells immortalized by a recombinant retrovirus. Int. Immunol. 4:1293-1302.
34. Fernandez-Vina, M.A., X. Gao, M.E. Moraes, J.R. Moraes, I. Salatie, S. Miller, J. Tsai, Y.P. Sun, Z. Layrisse, E. Gazi, et al. 1991. Alleles at four HLA class II loci determined by oligonucleotide hybridization and their associations in five ethnic groups. Immunogenetics. 34:299-312.
35. Fernandez-Vina, M.A., M. Falco, M. Cerna, E. Raimond, and P. Stastny. 1994. DQA1*03 subtypes have different associations with DRB1 and DQB1 alleles. Hum. Immunol. 39:290-298.
36. Lehmann, P.V., T. Forsthuber, A. Miller, and E.E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature (Lond.). 358:155-157.
37. Lehmann, P.V., E.E. Sercarz, T. Forsthuber, C.M. Dayan, and G. Gammon. 1993. Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today. 14:203-208.
38. Kaufman, D.L., M. Clare-Salzler, J. Tian, T. Forsthuber, G.S. Ting, P. Robinson, M.A. Atkinson, E.E. Sercarz, A.J. Tobin, and P.V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (Lond.). 366:69-72.
39. Wucherpfennig, K.W., B. Yu, K. Bhol, D.S. Monos, E. Argyris, R.W. Karr, A.R. Ahmed, and J.L. Strominger. 1995. Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proc. Natl. Acad. Sci. USA. 92:11935-11939.
40. Ahmed, A.R., E.J. Yunis, K. Khatri, R. Wagner, G. Notani, Z. Awdeh, and C.A. Apler. 1990. Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. Proc. Natl. Acad. Sci. USA. 87:7658-7662.
41. Ahmed, A.R., R. Wagner, K. Khatri, G. Notani, Z. Awdeh, C.A. Apler, and E.J. Yunis. 1991. Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris. Proc. Natl. Acad. Sci. USA. 88:5056-5060.
42. Matzner, Y., H.A. Erlich, C. Brautbar, A. Sanilevitch, M. Landau, S. Brenner, and A. Friedmann. 1995. Identical HLA class II alleles predispose to drug-triggered and idiopathic pemphigus vulgaris. Acta. Dermato-Venerol. 75: 12-14.
43. Lombardi, M.L., O. Mercuro, G. Tecame, C. Fusco, V. Ruocco, A. Salerno, G. Pirozzi, and C. Manzo. 1996. Molecular analysis of HLA DRB1 and DOB1 in Italian patients with pemphigus vulgaris. Tissue Antigen. 47:228-230.
44. O'Sullivan, D., T. Arrhenius, J. Sidney, M.-F. Del Guercio, M. Albertson, M. Wall, C. Oseroff, S. Southwood, S.M. Colon, F.C.A. Gaeta, and A. Sette. 1991. On the interaction of promiscuous antigenic peptides with different DR alleles: identification of common structural motifs. J. Immunol. 147:2663-2669.
45. Chicz, R.M., R.G. Urban, J.C. Gorga, D.A.A. Vignali, W.S. Lane, and J.L. Strominger. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:764-768.
46. Stern, L.J., J.H. Brown, T.S. Jardetzky, R. Urban, J.L. Strominger, and D.C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR complexed with an influenza virus peptide. Nature (Lond.). 368:215-221.
47. Jardetzky, T.S., J.C. Gorga, R. Busch, J. Rothbard, J.L. Strominger, and D.C. Wiley. 1990. Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding. EMBO (Eur. Mol. Biol. Organ.) J. 9:1797-1803.
48. Busch, R., C.M. Hill, J.D. Hayball, J.R. Lamb, and J.B. Rothbard. 1991. Effect of a natural polymorphism at residue 86 of the HLA-DR β chain on peptide binding. J. Immunol. 147:1292-1298.
49. Brown, J.H., T.S. Jardetzky, J.C. Gorga, L.J. Stern, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (Lond.). 364:33-39.
50. Hertl, M., M. Amagai, K. Ishii, R. Karr, and S.I. Katz. 1996. The HLA-DR11-restricted T cell response to the extracellular portion (EC1-5) of the pemphigus vulgaris antigen (PVA) is modulated by polymorphisms of the β1-chain. J. Invest. Dermatol. 106:813a. (Abstr.)
51. Sanders, V.M., R. Fernadez-Botran, R.L. Coffman, T.R. Mosmann, and E.S. Vitetta. 1988. A single antigen-specific B cell can conjugate to either a type 1 or type 2 helper T cell. Proc. Natl. Acad. Sci. USA. 85:7724-7728.
52. Lin, M.-S., and Y.-W. Chen. 1993. B cell differentiation. II. Isotype potential of a single B cell. Cell. Immunol. 150:343-352.
53. Armitage, R.J., B.M. Macduff, M.K. Spriggs, and W.C. Fanslow. 1993. Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J. Immunol. 150:3671-3680.