Use of suicide gene-expressing donor T-cells to control alloreactivity after haematopoietic stem cell transplantation

Journal of Internal Medicine

Volumn 249, Issue 4, 2001, Pages 369-377

  Tiberghien, P ^a,b  

^a UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^b ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

Alloreactivity; Gene therapy; Haematopoietic stem cell transplantation; Suicide gene; T lymphocytes

Indexed keywords

CD3 ANTIGEN; CYCLOSPORIN A; GANCICLOVIR; KANAMYCIN KINASE; THYMIDINE KINASE;

ACUTE TOXICITY; ALLOIMMUNITY; ALLOTRANSPLANTATION; CLINICAL TRIAL; CONFERENCE PAPER; DNA MODIFICATION; DONOR; DRUG SENSITIVITY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPES SIMPLEX VIRUS 1; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUICIDE GENE; SUICIDE GENE THERAPY; T LYMPHOCYTE;

ANIMALS; BONE MARROW TRANSPLANTATION; GENE EXPRESSION; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; SIMPLEXVIRUS; T-LYMPHOCYTES; THYMIDINE KINASE; VIRAL PROTEINS;

EID: 0035729970     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.2001.00809.x     Document Type: Conference Paper

References (43)

1. Prodrug-activating systems in suicide gene therapy
2. Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: An approach for specific in vivo donor T-cell depletion after bone marrow transplantation?
3. Retrovirus-mediated transfer of the herpes simplex type I thymidine kinase gene in alloreactive T lymphocytes
4. Infection efficiency of T-lymphocytes with amphotropic retroviral vectors is cycle dependent
5. Rapid selection of antigen-specific T lymphocytes by retroviral transduction
6. HLA-specific T-cell clones with stable expression of a suicide gene: A possible tool to drive and control a graft-versus-host-graft-versus-leukemia reaction?
7. Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes
8. Prevention of graft-versus-host disease in mice using a suicide gene expressed in T lymphocytes
9. Inhibition of graft-versus-host disease. Use of a T cell-controlled suicide gene
10. Ganciclovir-sensitive acute graft-versus-host disease in mice receiving herpes-simplex virus-thymidine kinase-expressing donor T cells in a bone marrow transplantation setting
11. Immunological defects after suicide gene therapy of experimental graft-versus-host disease
12. Mitigation of murine graft versus host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene
13. Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogeneic bone marrow transplantation
14. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
15. Phase I/II study of thymidine kinase-transduced donor lymphocyte infusions in patients with hematological malignancies
16. Adoptive immunotherapy for leukemia: Donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction
17. Adoptive immunotherapy for leukemia: Donor lymphocytes transduced with the herpes simplex thymidine kinase gene
18. Use of donor T lymphocytes expressing herpes-simplex thymidine kinase in allogeneic bone marrow transplantation: A phase I-II study
19. Administration of herpes-simplex thymidine-kinase-expressing donor T cells with a T cell-depleted allogeneic marrow graft
20. Peripheral blood lymphocytes as target cells of retroviral vector-mediated gene transfer
21. Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: Clinical follow-up and improved new vectors
22. Long term follow-up in 30 patients receiving HSV-tk transduced donor lymphocytes after allo-BMT
23. Development of a competitive PCR method for in vitro and in vivo quantification of herpes simplex virus thymidine kinase and neomycin resistance-expressing cells used in a clinical trial
24. Extensive vitiligo following treatment of cutaneous chronic graft-versus-host disease by ganciclovir in a patient having received herpes simplex virus thymidine kinase-expressing donor T cells
25. In vivo alloreactive potential of ex vivo-expanded primary T lymphocytes
26. Differential effects of cyclosporin a on the alloreactivity of fresh and ex vivo-expanded T lymphocytes
27. Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir
28. T-lymphocyte function after retroviral-mediated thymidine kinase gene transfer and G418 selection
29. Retrovirus-mediated gene transfer in primary T lymphocytes: Influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire
30. Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector
31. Costimulatory approaches to adoptive immunotherapy
32. Establishment of an optimised gene transfer protocol for human primary T lymphocytes according to clinical requirements
33. T lymphocyte transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: Comparison of four different infection protocols
34. Retrovirus-mediated gene transfer into T Cells: 95% transduction efficiency without further in vitro selection
35. T-cell-mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
36. Increased susceptibility to tolerance induction in T cell depleted hosts during immune reconstitution
37. A humanuzed Fas receptor-based suicide switch expressed in human T-lymphocytes for the induction of controlled graft versus leukemia
38. Molecular mechanism for ganciclovir resistance in human T-lymphocytes transduced with vectors carrying the herpes simplex virus thymidine kinase gene
39. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematological diseases
40. Cytotoxic T-lymphocyte-defined human minor histocompatibility antigens with a restricted tissue distribution
41. Allogeneic peripheral-blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer
42. Stem cell transplantation for severe autoimmune diseases: Progress and problems
43. The effects of chimeric cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients