Retrovirus-mediated gene transfer in primary T lymphocytes: Influence of the transduction/selection process and of ex vivo expansion on the T cell receptor β chain hypervariable region repertoire

Human Gene Therapy

Volumn 11, Issue 8, 2000, Pages 1151-1164

  Ferrand, Christophe ^a   Robinet, Eric ^a   Contassot, Emmanuel ^a   Certoux, Jean Marie ^a   Lim, Annick ^b   Hervé, Patrick ^a   Tiberghien, Pierre ^a  

^a ETABLISSEMENT FRANÇAIS DU SANG   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; OKT 3; T LYMPHOCYTE RECEPTOR BETA CHAIN; THYMIDINE KINASE;

ARTICLE; CELL ACTIVATION; CLINICAL TRIAL; COMPLEMENTARITY DETERMINING REGION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA MODIFICATION; GENE TRANSFER; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; RETROVIRUS; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIGENS, CD28; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; DNA, COMPLEMENTARY; GENE TRANSFER TECHNIQUES; GENES, T-CELL RECEPTOR BETA; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; KINETICS; LEUKOCYTES, MONONUCLEAR; MUROMONAB-CD3; OLIGONUCLEOTIDES; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; T-LYMPHOCYTES; TIME FACTORS; TRANSDUCTION, GENETIC;

EID: 0034690616     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340050015202     Document Type: Article

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