T lymphocyte transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: Comparison of four different infection protocols

Journal of Hematotherapy and Stem Cell Research

Volumn 8, Issue 6, 1999, Pages 645-652

  Di Ianni, Mauro ^a   Di Florio, Sabrina ^a   Venditti, Gigliola ^a   Falzetti, Franca ^a   Mannoni, P ^b   Martelli, Massimo F ^a   Tabilio, Antonio ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b INSTITUT PAOLI CALMETTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; INTERLEUKIN 2; THYMIDINE KINASE; VIRUS VECTOR;

ARTICLE; CENTRIFUGATION; COCULTURE; CONTROLLED STUDY; GENE TRANSFER; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; RETROVIRUS; SUPERNATANT; T LYMPHOCYTE; TRANSGENE;

CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CENTRIFUGATION; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DRUG RESISTANCE, MICROBIAL; ENZYME INDUCTION; FIBRONECTINS; GANCICLOVIR; GENES, REPORTER; GENETIC VECTORS; GENTAMICINS; IMMUNOPHENOTYPING; INTERLEUKIN-2; KANAMYCIN KINASE; LYMPHOCYTE ACTIVATION; MOLONEY MURINE LEUKEMIA VIRUS; PHYTOHEMAGGLUTININS; POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; SAFETY; SIMPLEXVIRUS; T-LYMPHOCYTES; THYMIDINE KINASE; TRANSFECTION; VIRAL PROTEINS;

EID: 0033403833     PISSN: 15258165     EISSN: None     Source Type: Journal    
DOI: 10.1089/152581699319812     Document Type: Article

References (29)

1. Anderson WF. (1992). Human gene therapy. Science 256:808.
2. Tolstoshev P. (1993). Gene therapy, concepts, current trials and future directions. Annu Rev Pharmacol Toxicol 32:573.
3. Miller DA. (1990). Progress toward human gene therapy. Blood 76:271.
4. Mulligan RC. (1993). The basic science of gene therapy. Science 260:926.
5. Palsson B, and S Andreadis. (1997). The physico-chemical factors that govern retrovirus-mediated gene transfer. Exp Hematol 25:94.
6. Morgan JR, JM LeDoux, RG Snow, et al. (1995). Retro-virus infection: effect of time and target cell number. J Virol 69:6994.
7. Culver K, K Cornetta, R Morgan, et al. (1991). Lymphocytes as cellular vehicles for gene therapy in mouse and man. Proc Natl Acad Sci USA 88:3155.
8. Djian P, M Philips, and H Green. (1988). Suppression of SV40-promoted gene expression by differentiation of preadipose cells. Genes Dev 2:1251.
9. Bunnell BA, L Mesler Muul, RE Donahue, et al. (1995). High efficient retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes. Proc Natl Acad Sci USA 92:7739.
10. Fehse B, UM Schade, L Zhixiong, et al. (1998). Highly efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin. Br J Haematol 102:566.
11. Tiberghien P, CW Reynolds, J Keller, et al. (1994). Ganciclovir treatment of herpes simplex thymidine kinase-transduced T lymphocytes: an approach for specific in vivo donor T cell depletion after bone marrow transplantation? Blood 84:1333.
12. Di Ianni M, S Di Florio, G Venditti, et al. (1999). T-lymphocyte function after retroviral mediated thymidine kinase gene transfer and G418 selection. Cancer Gene Ther, in press.
13. Di Ianni M, C Casciari, R Ciurnelli, et al. (1997). Retro-viral transfer of herpes simplex virus-thymidine kinase and beta-galactosidase genes into U937 cells with bicistronic vector. Leukemia Res 21:951.
14. Varmus H. (1988). Retroviruses. Science 240:1427.
15. Di Ianni M, C Casciari, R Ciurnelli, et al. (1996). Beta-galactosidase transduced T lymphocytes: a comparison between stimulation by either PHA and IL-2 or a mixed lymphocyte reaction. Haematologica 81:410.
16. Srivastava S, and J Minowada. (1973). Terminal deoxynucleotidyl transferase activity in a cell line (MOLT4) derived from peripheral blood of a patient with acute lymphoblastic leukemia. Biochem Biophys Res Commun 1973;51:529.
17. Bonini C, G Ferrari, S Verzelletti, et al. (1997). HSV-tk gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276:1719.
18. Chuck A, and BO, Palsson. (1996). Consistent and high rates of gene transfer can be obtained using the flow through transduction over a wide range of retroviral titers. Hum Gene Ther 7:743.
19. Chuck A, and BO Palsson. (1996). Retroviral infection is limited by brownian motion. Hum Gene Ther 7:1527.
20. Andreadis ST, D Brott, and AO Fuller. (1997). Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours. J Virol 71:7541.
21. Hanenberg H, LX Xiao, D Dilloo, et al. (1996). Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nature Med 2:876.
22. Imbert AM, R Costello, J Imbert, et al. (1994). Highly efficient retroviral gene transfer into human primary T-lymphocytes derived from peripheral blood. Cancer Gene Ther 1:259.
23. + donors. Prelude to a ribozyme gene therapy trial. Gene Ther 3:599.
24. Hutchings M, K Moriwaki, D Dilloo, et al. (1998). Increased transduction efficiency of primary hematopoietic cells by physical colocalization of retrovirus and target cells. J Hematother 7:217.
25. Springett GM, RC Moen, and S Anderson. (1989). Infection efficiency of T lymphocytes with amphotropic retro-viral vectors is cell cycle dependent. J Virol 63:3865.
26. Yabkowitz R, VM Dixit, N Guo, et al. (1993). Activated T cell adhesion to thrombopidin is mediated by the alpha 4 beta 1 (VLA-4) and alpha 5 beta 1 (VLA-5) integrins. J Immunol 151:149.
27. Pallis M, A Robins, and RA Powell. (1997). Peripheral blood lymphocytes binding to a soluble FITC-fibronectin conjugate. Cytometry 28:1595.
28. Munshi NC, R Govindarajan, R Drake, et al. (1997). Thymidine kinase (tk) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir. Blood 89:1334.
29. Di Ianni M, A Terenzi, K Perruccio, et al. (1999). 5-Aza-cytidine prevents transgene methylation in vivo. Gene Ther 6:703.