Stem cell transplantation for severe autoimmune diseases: Progress and problems

Haematologica

Volumn 83, Issue 8, 1998, Pages 733-743

  Marmont, Alberto M ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Autoimmune diseases; Stem cell transplantation

Indexed keywords

ALLOGENIC BONE MARROW TRANSPLANTATION; AUTOIMMUNE DISEASE; AUTOTRANSPLANTATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MULTIPLE SCLEROSIS; MYASTHENIA GRAVIS; REVIEW; RHEUMATOID ARTHRITIS; STEM CELL TRANSPLANTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIC PURPURA; THYROIDITIS;

ADOPTIVE TRANSFER; ADULT; ANIMALS; AUTOIMMUNE DISEASES; BONE MARROW TRANSPLANTATION; FEMALE; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICE; MICE, INBRED NOD; MULTIPLE SCLEROSIS; NEOPLASMS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 0031723134     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (148)

1. Morton JL, Siegel BV. Transplantation of autoimmune potential. Development of antinuclear antibodies in H-2 histocompatible recipients of bone marrow from New Zealand Black mice. Proc Natl Acad Sci USA 1974; 71: 2162-6.
2. Denman AM, Russel AS, Denman EJ. Adoptive transfer of the disease of New Zealand black mice to normal mouse strains. Clin Exp Immunol 1969; 5:567-70.
3. van Bekkum DW. Review: BMT in experimental autoimmune diseases. Bone Marrow Transplant 1993; 11:183-7.
4. Ikehara S. The prospects for BMT-from mouse to human. In: Ikehara S, Takaku F, Good RA, eds. Bone Marrow Transplantation. Basic and Clinical Studies. Tokyo-Singapore: Springer 1996. p. 302-31.
5. Ikehara S. Bone marrow transplantation for autoimmune diseases. Acta Haematol 1998; 99:116-32.
6. Snowden JA, Brooks PM, Biggs JC. Haemopoietic stem cell transplantation for autoimmune disease. Br J Haematol 1997; 99:9-22.
7. Müller R, Sravelnick N. Transgenic knock-out mice: tools to study autoimmunity. Curr Opin Immunol 1995; 7:799-803.
8. Volpe R, Kasuga Y, Akasu F, et al. The use of the severe combined immunodeficient mouse and the "athymic" nude mouse as models for the study of human autoimmue thyroid disease. Clin Immunol Immunopathol 1993; 67: 93-9.
9. Krams SM, Dorshkind K, Gershwin CA, et al. Generation of biliary lesion after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice. J Exp Med 1989; 170:1919-30.
10. Juhasz I, Lazarus GS, Murphy GF et al: Development of pemphigus vulgaris-like lesion in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients. J Clin Invest 1993; 92:2401-7.
11. Tighe H, Silverman GJ, Kozin F, et al. Autantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients. Eur J Immunol 1990; 20:1843-8.
12. Akizuki M, Reeves JP, Steinberg AD. Expression of autoimmunity by NZ/NZW marrow. Clin Immunol Immunopathol 1978; 10:247-50.
13. Levite M, Zinger H, Mozes E, Reisner Y. Systemic lupus erythematosus-related autoantibody production in mice is determined by bone marrow derived cells. Bone Marrow Transplant 1993; 12:79-183.
14. Reininger L, Radskiewcz T, Kosco. Development of autoimmune disease in SCID mice populated with long-term "in vitro" proliferating (NZBxNZW) F1 pre B cells. J Exp Med 1992; 176:1343-53.
15. Blank M, Krause J, Lanir N, et al. Transfer of experimental antiphospholipid syndrome by bone marrow cell transplantation. The importance of T cell. Arthritis Rheum 1995; 38:115-22.
16. Ehrenstein MR, Horsfall A, Isenberg DA. Immunopathology of lupus. In: Schur PH, ed. The clinical management of systemic lupus erythematosus. Lippincott-Raven, Philadelphia-New York, 1996; 17-34.
17. Freedman A, Zhu H, Levine JD, et al. Generation of human T lymphocytes from bone marrow CD34+ cells in vitro. Nature Med 1996; 2:46-51.
18. Rawlings DJ, Quan S, Hao Q-L, et al. Differentiation of human CD34+ CD38-cord blood stem cells into B cell progenitors in vitro. Exp Hematol 1997; 25:66-72.
19. Kawamura M, Hisha H, Li Y, Fukuhara S, Ikehara S. Distinct qualitative differences between normal and abnormal hemopoietic stem cells in vivo and in vitro. Stem Cells 1997; 15:56-62.
20. Castano L, Eisenbarth GS. Type I diabetes: a chronic autoimmune disease of human, mouse, and rat. Ann Rev Immunol 1990; 8:647-61.
21. Li H, Kaufman CL, Boggs SS, et al. Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune disease and reverses insulitis in nonobese diabetic (NOD) mice. J Immunol 1996; 156:380-8.
22. Cyster JG, Hartley SB, Goodnow CC. Competition for follicular niches excludes self-reactive cells from the recirculation b-cell repertoire. Nature 1994; 371:389-92.
23. Knaan-Shanzer S, Houben P, Kinwel Bohrè EPM, van Bekkum DW. Remission induction of adjuvant arthritis in rats by total body irradiation and autologous bone marrow transplantation. Bone Marrow Transplant 1992; 8: 333-8.
24. van Gelder M, van Bekkum DW. Effective treatment of relapsing autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation. Bone Marrow Transplant 1996; 18:1029-34.
25. van Gelder M, Mulder AH, van Bekkum D. Treatment of relapsing experimental autoimmune encephalomyelitis with largely MHC-matched allogeneic bone marrow transplantation. Transplantation 1996; 62:810-8.
26. Ende N, Czarnesky J, Raveche E. Effect of human cord blood transfer on survival and disease activity in MLR-lpr/lpr mice. Clin Immunol Immunopathol 1995; 75:190-5.
27. Rose NR, Bona C. Defining criteria for autoimmune disease (Witebsky's postulates revisited). Immunol Today 1993; 114:426-30.
28. Cash JM, Wilder RM, eds. Treatment-resistant rheumatic disease. Rheum Dis Clin North Am 1995; 21:1-270.
29. Marmont AM. Immune ablation followed by allogeneic or autologous bone marrow transplantation: a new treatment for severe autoimmune diseases? Stem Cells 1994; 12:125-35.
30. Theophilopoulos AN. The basis of autoimmunity. Part II. Genetic predisposition. Immunol Today 1995; 16:150-9.
31. Theophilopoulos AN. The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition. Immunol Today 1995; 16:90-8.
32. Boitard Ch. B Cells and autoantibody production in autoimmune diseases: Springer, Landes Co., 1996.
33. Marmont AM. Trattamento delle malattie autoimmuni gravi. Immunoablazione integrata da cellule staminali ematopoietiche. Rec Progr Med 1996; 87:480-6.
34. Marmont AM. Immune ablation followed by stem cell transplantation (allogeneic) or support (autologous) for severe autoimmune diseases. Progress, controversies and suggested guidelines. In: Carella AM, ed. Autologous stem cell transplantation. Biological and clinical results in malignancies. Dordrecht: Harwood Acad. Publ. 1997:441-50.
35. Marmont AM. Stem cell transplantation for severe autoimmune disorders, with special reference to rheumatic diseases. J Rheumatol 1997; 24 (Suppl 48):13-1.
36. Tyndall A, Gratwohl A. Blood and marrow stem cell transplants in auto-immune disease: a consensus report written on behalf of the European League against Rheumatism (EULAR) and the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 1997; 19:643-5.
37. Cook DJ, Mulrow CD, Haynes RB. Systematic reviews: synthesis of best evidence for clinical interventions. Ann intern Med 1997; 126:376-80.
38. Ikehara S. Autoimmune diseases as stem cell disorders: Normal stem cell transplant for their treatment. Int J Mol Med 1998; 1:5-15.
39. Tyndall A, Gratwohl A. Hemopoietic blood and marrow transplants in the treatment of severe autoimmune disease. Current Opinion Hematol 1997; 4:390-4.
40. Marmont AM. Defining criteria for autoimmune diseases [letter]. Immunol Today 1994; 15:388.
41. Bargetzi MJ, Schonenberger A, Tichelli A, et al. Celiac disease transmitted by allogeneic non-T depleted bone marrow transplantation. Bone Marrow Transplant 1997; 20: 607-9.
42. Kishimoto Y, Yamamoto Y, Ito T, et al. Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation. Bone Marrow Transplant 1997; 19:1041-3.
43. Karthaus M, Gabrysiak T, Brabant G, et al. Immune thyroiditis after transplantation of allogeneic CD34+ selected peripheral cells. Bone Marrow Transplant 1997; 20: 697-9.
44. Berisso GA, van Lint MT, Occhini D, Gualandi F, Bacigalupo A, Marmont AM. Adoptive development of different antithyroid autoantibodies following allogeneic blood and marrow transplantation. Bone Marrow Transplant; in press.
45. Snowden JA, Atkinson K, Kearney P, et al. Allogeneic bone marrow transplantation from a donor with severe active rheumatoid arthritis not resulting in adoptive transfer of disease to recipient. Bone Marrow Transplant 1997; 20: 71-3.
46. Sturfelt G, Lenhoff S, Sallerfors B, Nived O, Truedsson L, Sjöholm AG. Transplantation with allogeneic bone marrow from a donor with systemic lupus erythematosus (SLE): successful outcome in the recipient and induction of an SLE flare in the donor. Ann Rheum Dis 1996; 55:638-41.
47. Marmont AM. Immunological aspects of aplastic anaemia. Bailliéres's Clin Immunol Allergy 1987; 1:327-42.
48. Young NS. Autoimmunity and its treatment in aplastic anemia. Ann Intern Med 1997; 126:166-8.
49. Young NS, Macejewski JP. Mechanism of disease: the pathophysiology of acquired aplastic anemia. N Engl J Med 1997; 336:1365-72.
50. Bacigalupo A, Marmont AM. Aplastic anemia: pathogenesis and treatment. Semin Clin Immunol 1998; in press.
51. Passweg JR, Socié G, Hinterberger W, et al. Bone marrow transplantation for severe aplastic anemia: has outcome improved? Blood 1997; 90:858-64.
52. Nelson JL, Torrez R, Louie FM, Choe OS, Storb R, Sullivan KM. Pre-existing autoimmune disease in patients with long-term survival after allogeneic bone marrow transplantation. J Rheumatol 1997; 24(Suppl 48):23-9.
53. McKendry RJR, Huebsch L, Le Clair B. Progression of rheumatoid arthritis following bone marrow transplantation: a case report with a 13-years follow-up. Arthritis Rheum 1996; 39:1246-53.
54. Snowden JA, Kearney P, Kearney A, et al. Long-term outcome of autoimmune disease following allogeneic bone marrow transplantation. Arthritis Rheum 1998; 41:453-9.
55. Cetkovsky P, Koza V, Cetkovska P, Svojgrovà M. Successful treatment of severe Shulman's syndrome by allogeneic bone marrow transplantation. Bone Marrow Transplant 1998; 21:637-9.
56. Lopez-Cubero SO, Sullivan KM, McDonald GB. Course of Crohn's disease after allogeneic marrow transplantation: report of 6 cases. Gastroenterology 1998; 114:433-40.
57. Mc Allister LD, Beatty PG, Rose J. Allogeneic bone marrow transplant for chronic myelogenous leukemia in a patient with multiple sclerosis. Bone Marrow Transplant 1997; 19:395-7.
58. Raetz E, Beatty PG, Adams RH. Treatment of severe Evans syndrome with an allogeneic cord blood transplant. Bone Marrow Transplant 1997; 20:427-9.
59. Vento S, Cainelli F, Renzini C, Ghironzi G, Concia E. Resolution of autoimmune hepatitis after bone marrow transplantation. Lancet 1996; 348:544-5.
60. Van Gelder M, van Bekkum DW. Effective treatment of relapsing autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation. Bone Marrow Transplant 1996; 13:1029-34.
61. Slavin S: Treatment of life-threatening autoimmune diseases with myeloablative doses of immunosuppressive agents: experimental background and rationale for ABMT. Bone Marrow Transplant 1993; 12:201-10.
62. Karussis DM, Vourka-Karussis U, Lehmann D, et al. Prevention and reversal of adoptively transferred chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation. J Clin Invest 1993; 92:765-72.
63. Passweg J, Passas A, Furst D, et al. Autologous stem cell transplantation for autoimmune disease. A preliminary report [abstract]. Bone Marrow Transplant 1998, 21 (Suppl 1):51.
64. Euler HH, Marmont AM, Bacigalupo A, et al. Early recurrence or persistence of autoimmune disease after unmanipulated autologous stem cell transplantation. Blood 1996; 88:3621-5.
65. Joske DJ, Ma D, Langlands DR, Owry EI. Autologous bone marrow transplantation for rheumatoid arthritis. Lancet 1997; 350:337-8.
66. Durez P, Toungouz M, Kentos A, et al. Clinical remission in a case of refractory systemic and erosive rheumatoid arthritis after autologous T cell depleted CD34+ peripheral blood stem cell transplantation [abstract]. Bone Marrow Transplant 1998; 21(Suppl 1):51.
67. Snowden JA, Milliken ST, Brooks PM, Biggs JC. High dose cyclophosphamide (Cy) with autologous stem cell rescue in severe active rheumatoid arthritis (RA). A dose escalation study [abstract]. Bone Marrow Transplant 1998; 21 (Suppl 1):52.
68. Cooley HM, Snowden JA, Grigg A, Wicks IP. Outcome of rheumatoid arthritis and psoriasis following autologous stem cell transplantation for hematologic malignancy. Arthritis Rheum 1997; 40:1712-5.
69. Wulfraat NM, van Royen A, Vossen JP, Kuis W. Autologous bone marrow transplantation in refractory polyarticular and systemic JCA [abstract]. Bone Marrow Transplant 1998; 21(Suppl 1):50.
70. Tyndall A, Black C, Finke J, et al. Treatment of systemic sclerosis with autologous haemopoietic stem cell transplantation [research letter]. Lancet 1997; 349:254.
71. Tamm M, Gratwohl A, Tichelli A, Perruchoud A, Tyndall A. Autologous haemopoietic stem cell transplantation in a patient with severe pulmonary hypertension complicating connective tissue disease [letter]. Ann Rheum Dis 1997; 15:39.
72. Marmont AM. Perspective: Immune ablation with stem cell rescue: a possible cure for systemic lupus erythematosus? Lupus 1993; 2:151-6.
73. Meloni G, Capria S, Vignetti M, Mandelli F. Blast crisis of chronic myelogenous leukemia in long-lasting systemic lupus erythematosus: regression of both diseases after autologous bone marrow transplantation [letter]. Blood 1997; 89:4650.
74. Snowden JA, Patton WN, O'Donnell JL, Hannah EE, Hart DNJ. Prolonged remission of long-standing lupus erythematosus after autologous bone marrow transplant for non-Hodgkin Lymphoma. Bone Marrow Transplant 1997; 19:1247-50.
75. Rösler W, Manger B, Repp R, et al. Autologous PBCT in a patient with lymphoma and Sjögren's syndrome: complete remission of lymphoma without control of the autoimmune disease. Bone Marrow Transplant 1998; in press.
76. Marmont AM, van Lint MT, Gualandi F, Bacigalupo A. Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration. Lupus 1997; 6:545-8.
77. Burt RK, Traynor A, Ramsay-Goldman R. Hematopoietic stem cell transplantation for systemic lupus erythematosus. N Engl J Med 1997; 337:1777-8.
78. Traynor AE, Burt RK, Jung L, Mujais S, Ramsey-Goldman R, Schroeder JL. Hematopoietic stem cell transplant for active systemic lupus erythematosus [abstract]. Lupus 1998; 7(Suppl 1):120.
79. Fouillard L, Miossec P, Leon A, et al. Autologous peripheral blood CD34 positive stem cell transplantation in the treatment of severe systemic lupus erythematosus (SLE). A case report [abstract]. Bone Marrow Transplant 1998; 21 (Suppl 1):53.
80. Musso M, Porretto F, Crescimanno A, et al. Treatment of severe autoimmune diseases with autologous CD34+ PBPC transplantation. Lupus 1998; in press.
81. Fassas A, Anagnostopoulos A, Giannaki E, Vadikolia C, Zambouli D, Papaioannou G. Autologous blood stem cell therapy for autoimmune pancytopenia due to systemic lupus erythematosus [abstract]. Bone Marrow Transplant 1998; 21(Suppl 1):53.
82. Lim SH, Kell J, Al-Sabah A, Bashi W, Bailey-Wood R. Peripheral blood stem-cell transplantation for refractory autoimmune thrombocytopenic purpura [research letter]. Lancet 1997; 340:475.
83. Skoda RC, Tichelli A, Tyndall A, Hoffmann T, Gillessen S, Gratwohl A. Autologous peripheral blood stem cell transplantation in a patient with chronic autoimmune thrombocytopenia. Br J Haematol 1997; 99:56-7.
84. Marmont AM, van Lint MT, Occhini D, Lamparelli T, Bacigalupo A. Failure of autologous stem cell transplantation in refractory thrombocytopenic purpura. Bone Marrow Transplant 1998, in press.
85. Schinco PC, Tamponi B, Montarulli B, Caracciolo D, Tarella C. Low antibody response in a hemophiliac with natural anti-VIII: C inhibitors treated with HDS and autograft for a concomitant non-Hodgkin's lymphoma [abstract]. Bone Marrow Transplant 1998; in press.
86. Burt RK, Miller SD. Bone marrow transplantation for multiple sclerosis: returning to Pandora's box. Immunol Today 1997; 18:559-61.
87. Fassas A, Anagnastopoulos A, Kazis A, et al. Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study. Bone Marrow Transplant 1997; 20:631-8.
88. Burt RK, Traynor AE, Cohen B, et al. T cell depleted autologous hemopoietic stem cell transplantation for multiple sclerosis: report on the first three patients. Bone Marrow Transplant 1998; 21:537-41.
89. Brooks P, Biggs JC, Snowden J. Haematopoietic stem cell transplantation for autoimmune disease. CellPro's Newsletter August 1-3.
90. Thomas ED. Pros and Cons of stem cell transplantation for autoimmune disease. J Rheumatol 1997; 24(Suppl 48):100-2.
91. Gilkeson GS, Rippen AM, Pisetsky DS. Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J Clin Invest 1995; 95:1348-402.
92. Pisetsky DS. DNA and the immune system. Ann Intern Med 1997; 126:169-71.
93. Boyd CN, Ramberg RC, Thomas ED. The incidence of recurrence of leukemia in donor cells after allogeneic bone marrow transplantation. Leuk Res 1982; 6:833-7.
94. Marmont AM, Frassoni F, Bacigalupo A, et al. Recurrence of Ph-positive leukemia after marrow transplantation for chronic granulocytic leukemia. N Engl J Med 1984; 310: 903-6.
95. Marmont AM, van Bekkum DW: Stem cell transplantation for severe autoimmune diseases: new proposals but still unanswered questions. Bone Marrow Transplant 1995; 16:497-8.
96. Storek J, Witherspoon RP, Storb R, et al. T cell reconstitution after bone marrow transplantation does not resemble T cell development in early life. Bone Marrow Transplant 1995; 16:413-7.
97. Heitger A, Neu N, Kern H, et al. Essential role of the thymus to reconstitute naive (CD45RA+) T-helper cells after human allogeneic bone marrow transplantation. Blood 1997; 90:850-7.
98. Cavenagh JD, Milne TM, Macey MG, Newland AC. Thymic function in adults: evidence derived from immune recovery patterns following myeloablative chemotherapy and stem cell infusion. Br J Haematol 1997; 97:673-6.
99. Small TN, Avigan D, Dupont B, et al. Immune reconstitution following T-cell depleted bone marrow transplantation: Effect of age and post-transplant graft rejection prophylaxis. Biol Blood Marrow Transplant 1997; 3:65-75.
100. Atkinson K. Reconstruction of the haematopoietic and immune system after marrow transplantation. Bone Marrow Transplant 1990; 5:209-26.
101. Witherspoon RP. Immunological reconstruction after allogeneic marrow, autologous marrow or autologous peripheral blood stem cell transplantation. In: Atkinson K, ed. Clinical bone marrow transplantation. Cambridge, University Press, 1994. p. 62-72.
102. Roberts MM, To LB, Gillis D, et al. Immune reconstitution following peripheral blood stem cell transplantation and allogeneic bone marrow transplantation. Bone Marrow Transplant 1993; 12:469-75.
103. To LB, Haylock DN, Simmons PJ, Juttner CA. Review article. The biology and clinical uses of blood stem cells. Blood 1997; 89:2233-358.
104. Olivieri A, Brunori M, Offidani M, et al. A detailed study on immune recovery in 50 patients autotransplanted with blood progenitor cells [abstract]. Exp Hematol 1996; 24: 1088.
105. Hakim FT, Cepada R, Kaimei S, et al. Constraints on CD4+ recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood 1997; 90:3789-98.
106. Steinman L. Multiple sclerosis: a co-ordinated immunological attack against myelin in the central nervous system. Cell 1996; 85:299-302.
107. Hutchings P, Cooke A, Dawe K, et al. Active suppression induced by anti-CD4. Eur J Immunol 1993; 23:965-8.
108. Waldmann H, Cobbold S. Reprogramming the immune system. In Lydyard PM, Brostoff J, eds. Autoimmune disease. Aethiopathogenesis, diagnosis and treatment. Oxford: Blackwell, 1994. p. 164-5.
109. Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today 1991; 12:256-7.
110. Allen J E, Maizels RM. TH1-TH2: reliable paradigm or dangerous dogma? Immunol Today 1997; 18:387-92.
111. Röcken M, Biedermann T, Ogilvie A. The role of TH1 and TH2 dichotomy: implications for autoimmunity. Rev Rheum 1997; 64(10, suppl.):131-7.
112. Gale RP, Champlin RE: How does bone marrow transplantation cure leukemia? Lancet 1984; 2:28-31.
113. Sykes M, Szot G, Swenson K, Pearson DA. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nature Med 1997; 3:783-7.
114. Giralt S, Estey E, Albitar M, et al. Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus leukemia without myeloablative therapy. Blood 1996; 89:4531-6.
115. Slavin S, Nagler A, Naparstek, et al. Nonmyeloablative stem cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 1998; 91:756-83.
116. van Rhee F, Kolb H-J. Donor leukocyte transfusions for leukemic relapse. Current Opinion Hematol 1995; 2:423-30.
117. Bacigalupo A, Soracco M, Vassallo F, et al. Donor lymphocyte infusions (DLI) in patients with chronic myeloid leukemia following allogeneic bone marrow transplantation. Bone Marrow Transplant 1997; 19:927-32.
118. Mackinnon S. Donor leukocyte infusions. Baillére's Clin Haematol 1997; 10:357-67.
119. Van Bekkum DW, Marmont AM, Tyndall A, et al. Severe autoimmune disease: a new target for bone marrow transplantation. Stem Cells 1996; 14:460-72.
120. Bach JF, Koutouzov S. New clues to systemic lupus. Lancet 1997; 350(Suppl III):11.
121. Mendonça LLF, Tyndall A. Bone marrow transplantation in the treatment of autoimmune disease: evolving concepts and early experience. Lupus 1997; 6:561-3.
122. Sinha AA, Lopez MT, McDevitt HO. Autoimmune diseases: the failure of self tolerance: Science 1990; 248:1380-8.
123. Mandell BF, ed. Life-threatening complications of autoimmune diseases. Rheum Dis Clin North Am 1997; 23:219-481.
124. Karoussis DM, Vourka-Karussis U, Lehmann D, et al. Immunomodulation of autoimmunity in MRL/lpr mice with syngeneic bone marrow transplantation (SBMT). Clin Exp Immunol 1995; 100:111-7.
125. Curtis RE, Rowlings PA, Deeg HJ, et al. Solid cancers after bone marrow transplantation. N Engl J Med 1997; 336: 897-904.
126. Pedersen-Bjergaard J. Radiotherapy- and chemotherapy-induced myelodysplasia and acute myeloid leukemia: a review. Leuk Res 1992; 16:61-71.
127. Stone RM, Neuberg D, Soiffer R, et al. Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol 1994; 12:2535-42.
128. Dorrington DL, Vose JM, Anderson JR, et al. Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem cell transplantation for lymphoid malignancies. J Clin Oncol 1994; 12: 2527-34.
129. Van Leeuwen FE. Risk of acute myelogenous leukemia and myelodysplasia following cancer treatment. Bailliére Clin Haematol 1996; 9:57-85.
130. Ponchio L, Eaves C, Hogge D, et al. Both cycling and noncycling primitive progenitors continue to be mobilised into the circulation during the leukapheresis of patients pretreated with chemotherapy and G-CSF. Br J Haematol 1997; 94:394-402.
131. Koerbling M, Huh YO, Durett A, et al. Allogeneic blood stem cell transplantation: Peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy-1dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease. Blood 1995; 86:2842-51.
132. Glass B, Uharek L, Zeis M, et al. Allogeneic peripheral blood progenitor cell transplantation in a murine model: evidence for an improved graft-versus-leukemia effect. Blood 1997; 90:1694-700.
133. Anderlini P, Körbling M, Dale D, et al. Editorial. Allogeneic blood stem cell transplantation: considerations for donors. Blood 1997; 90:903-8.
134. McGonagh D, Rawstron A, Richards S, et al. A phase I study to address the safety and efficacy of granulocyte-colony-stimulating factor for the mobilization of hematopoietic progenitor cells in active rheumatoid arthritis. Arthritis Rheum 1997; 40:1838-42.
135. Snowden JA, Brooks PM, Milliken ST, et al. Haemopoietic stem cell (HSC) mobilisation with filgrastim in severe active rheumatoid arthritis (RA)[abstract]. Bone Marrow Transplant 1998; in press.
136. Deapen DM, Escalante A, Weinrib L, Langholz B, Horwitz DA, Mack TM. A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum 1992; 35: 311-8.
137. Arnett FC. The genetics of human lupus. In: Wallace DJ, Hahn BH, eds. Dubois' lupus erythematosus. Baltimore, Williams & Wilkins, 1997. p. 77-117.
138. Silberstein L, Jefferie LC. Placental blood banking: a new frontier in transfusion medicine. N Engl J Med 1996; 335: 199-202.
139. Wicks I, Cooley H, Szer J. Autologous hemopoietic stem cell transplantation. A possible cure for rheumatoid arthritis? Arthritis Rheum 1997; 40:1005-11.
140. Negrin RS, Blume KG. New pre-transplant regimens. In Carella AM, ed. Autologous stem cell transplantation. Biological and clinical results in malignancies. Dordrecht: Harwood Acad. Publ., 1997:195-200.
141. Euler HH, Schroder JO, Harten P, Zeuner RA, Gutschmidt HJ. Treatment-free remission in severe systemic lupus erythematosus following synchronisation of plasmapheresis with subsequent pulse cyclophosphamide. Arthritis Rheum 1994; 37:1784-94.
142. Wallace C, Sherry DD. Trial of intravenous pulse cyclophosphamide and methylprednisolone in the treatment of severe systemic-onset juvenile rheumatoid arthritis. Arthritis Rheum 1997; 40:1852-5.
143. Emery P. Rheumatoid arthritis: not yet curable with early intensive therapy. Lancet 1997; 350:304-5.
144. Berchtold P, McMillan R. Therapy of chronic thrombocytopenic purpura in adults. Blood 1989; 74:2309-17.
145. McMillan R. Therapy for adults with refractory chronic immune thrombocytopenic purpura. Ann Intern Med 1997; 126:307-14.
146. Reiner A, Gernsheimer T, Schlichter SJ. Pulse cyclophosphamide therapy for refractory autoimmune thrombocytopenic purpura. Blood 1995; 85:351-8.
147. Krance R, Brenner M. BMT beats autoimmune disease. Nature Medicine 1998; 4:153-5.
148. Hahn BH. The future of systemic lupus erythematosus: a look ahead. In: Wallace DJ, Hahn BH, eds. Dubois' Lupus Erythematosus. Baltimore, Williams & Wilkins, 1997. p. 1229-34.