The ocular lens epithelium

Bioscience Reports

Volumn 21, Issue 4, 2001, Pages 537-563

  Bhat, Suraj P ^a  

^a JULES STEIN EYE INSTITUTE   (United States)

Author keywords

Cataract; Epithelial cells; Eye lens; Fiber cells; Programmed cell death

Indexed keywords

APOPTOSIS; CANCER; CATARACT; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL MATURATION; CELL METABOLISM; CELL STRUCTURE; HUMAN; LENS EPITHELIUM; MOLECULAR BIOLOGY; MORPHOLOGY; PHENOTYPE; SHORT SURVEY; STEM CELL; SURFACE PROPERTY; VASCULARIZATION;

ADULT; AGING; APOPTOSIS; BIOLOGICAL TRANSPORT, ACTIVE; CATARACT; CELL COUNT; CELLS, CULTURED; ELECTROPHYSIOLOGY; EPITHELIUM; HUMANS; LENS, CRYSTALLINE; NEOPLASMS; ULTRAVIOLET RAYS;

EID: 0035724463     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1017952128502     Document Type: Short Survey

References (187)

1. Neoplastic transformation in vitro of hamster lens epithelium by Simian Virus 40
2. Proteolytic cleavage of N-Succ-Leu-Leu-Val-Tyr-AMC by the proteosome in lens epithelium from clear and cataractous human lens
3. Propagation and immortalization of human lens epithelial cells in culture
4. The molecular chaperone αA-crystallin enhances lens epithelial cell growth and resistance to UVA stress
5. DNA degradation in terminally differentiating lens fiber cells from chick embryos
6. Enhancement of differentiation of human lens epithelium in tissue culture by changes in cell-substrate adhesion
7. Synthesis of lens capsule in long-term culture of human lens epithelial cells
8. Noncontact specular microscopy of human lens epithelium
9. Intercellular communication between epithelial and fiber cells of the eye lens
10. The control of δ-crystallin gene expression during lens cell development: Dissociation of cell elongation, cell division, δ-crystallin synthesis and δ-crystallin mRNA accumulation
11. Distribution of rubidium-86 accumulated in the rabbit lens
12. Demonstration of a magnesium- and calcium-dependent ATPase on the outer surface of bovine lens epithelial cells
13. SV40-transformed hamster lens epithelial cells: A novel system for the isolation of cytoskeletal messenger RNAs and their translation products
14. Biochemical differences between three subcell-lines derived from SV40-transformed hamster lens cells
15. Disorganization of membranes and abnormal intermediate filament assembly lead to cataract
16. Extensions of life span by introduction of telomerase into normal human cells
17. 2+-ATPase activity in the human lens
18. Unscheduled DNA repair in human lens epithelium following in vivo and in vitro UV irradiation
19. Ultrastructural, biochemical and immunologic evidence of receptor-mediated endocytosis in the crystalline lens
20. An estimate of the human cell size in vivo
21. Replicative senescence and immortalization
22. Voltage-gated potassium channel genes
23. Use of lipophilic cation to monitor electrical membrane potential in the intact rat lens
24. Control of glycolysis in the lens
25. Telomerase activity in lens epithelial cells of normal and cataractous lenses
26. Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts
27. Characterization of Muscarinic receptors in human lens cells by pharmacologic and molecular techniques
28. Lens development: Fiber elongation and lens orientation
29. Spontaneous transformation of bovine lens epithelial cells
30. Transferrin in after-cataract and as a survival factor for lens epithelium
31. Gap junctions containing α8-connexin (MP70) in the adult mammalian lens epithelium suggests a reevaluation of its role in the lens
32. The photophysics and photobiology of the eye
33. Influence of external calcium and glucose on internal total and ionized calcium in rat lens
34. Analysis of telomere lengths in human corneal endothelial cells from donors of different ages
35. A study of human senile cataract: Growth and differentiation of lens epithelial cell in in vitro cell culture
36. Human lens epithelium in normal and cataractous lenses
37. Immortalized cells seem cancer-free so far
38. Transport of fluid by lens epithelium
39. Examination of the lens by phase-contrast microscopy
40. Biological effects of superoxide radical
41. The mechanism of cell death and phagocytosis in the early chick lens morphogenesis: A scanning electron microscopy and cytochemical approach
42. 2-induced uncoupling of bovine lens Na/K ATPase
43. Catalytic subunit isoforms of mammalian lens Na/K ATPase
44. Glutathione. A vital lens antioxidant
45. Peroxide-induced effects on lens cation transport following inhibition of glutathione reductase activity in vitro
46. Stimulation of the hexose monophosphate shunt in rabbit lens in response to oxidation of glutathione
47. 14C from uniformly labeled glucose by the normal and diabetic rabbit lens
48. Bovine lens epithelium: A suitable model for studying growth control mechanisms. C6-substituted purines inhibit cell flattening and growth stimulation of G0 cells
49. Cell death in normal vertebrate ontogeny
50. Lens metabolic cooperation: A study of mouse lens transport and permeability visualized with freeze-substitution autoradiography and electron microscopy
51. Connexins, connexons and intercellular communication
52. The crystalline lens. A system networked by gap junctional intercellular communication
53. The major intrinsic protein (MIP) of the bovine lens fiber membrane: Characterization and structure based on cDNA cloning
54. Some aspects of transport and digestion in the lens of the normal young adult rat
55. Embryonic lens induction: Shedding light on vertebrate tissue determination
56. The biosynthesis of basement membrane collagen in embryonic chick lens. 1. Delay between the synthesis of polypeptide chains and the secretion of collagen by matrix-free cells
57. Cell density of human lens epithelium in women higher than in men
58. TGF-β1 induces lens-cells to accumulate a smooth muscle actin, a marker for subcapsular cataracts
59. Intravitreal injection of TGF-b induces cataracts in rats
60. In vitro differentiation of cells of the lens epithelium of human fetus
61. Differentiation and dedifferentiation of rat lens epithelial cells in short- and long-term cultures
62. Aquaporins in complex tissues: Distribution of aquaporins 1-5 in human and rat eye
63. The control of cell division in the ocular lens
64. The lens: Development, proteins, metabolism and cataract
65. Human age-related cataract and lens epithelial cell death
66. Cation transport of the lens
67. Transformations between epithelium and mesenchyme: Normal, pathological and experimentally induced
68. Effect of selenite on epithelium of cultured rabbit lens
69. Lens epithelium: A primary target of UVG irradiation
70. The role of the lens epithelium in development of UV cataract
71. Degradation of differential oxidized alpha-crystallins in bovine lens epithelial cells
72. Physiological actions of taurine
73. Human lens epithelial cell line
74. A study of growth factor receptors in human lens epithelial cells and their relationship to fiber differentiation
75. Cholesterol induces apoptosis of corneal endothelial and lens epithelial cells
76. Lens actin: Purification and localization
77. A role for caspases in lens filter differentiation
78. Control of lens epithelial cell survival
79. A direct measurement of intracellular free calcium within the lens
80. Human lens epithelial cells in culture: A quantitative evaluation of growth rate and proliferative capacity
81. Features of embryonic induction
82. Molecular regulators involved in vertebrate eye development
83. Molecular characterization of a reduced glutathione transporter in the lens
84. Differential display detects altered gene expression between cataractous and normal human lenses
85. Cell density, morphology and mitotic index in normal and cataractous lenses
86. Localization and specificity of the transport system for sugars in the calf lens
87. Transport of L-glutamic acid and L-glutamine and their incorporation into lenticular glutathione
88. Studies on the crystalline lens. XI. The relative role of the epithelium and capsule in transport
89. Ultraviolet light induced DNA damage and repair in bovine lens epithelial cells
90. Tissue specific expression of a cloned chick δ-crystallin gene in mouse cells
91. Cell density and sex chromatin in lens epithelium of human cataracts
92. Expression of crystallins pax 6, filensin, CP49, MIP and MP20 in lens derived cell lines
93. The ultrastructure of epithelial and fiber cells in the crystalline lens
94. A re-examination of primate lens epithelial cell size, density and structure as a function of development, growth and age
95. Which factors stimulate lens fiber cell differentiation in vivo?
96. Experimental studies on the development of the eye in amphibia. I. Origin of the lens Renu Palustris
97. Pax-6 is first expressed in a region of ectoderm anterior to the early neural plate: Implications for stepwise determination of the lens
98. Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract
99. Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals
100. Calcimycin induced lens epithelial cell apoptosis contributes to cataract formation
101. A reassessment of protein synthesis by lens nuclear fiber cells
102. Polyol accumulation in cultured human lens epithelial cells
103. Endocytosis of macromolecules in the lenses of guinea pig and rabbit
104. Membrane conductance and potassium permeability of the rat lens
105. Oncogenesis of the lens in transgenic mice
106. Lens cell populations studied in human donor capsular bags with implanted intraocular lenses
107. Physiological properties of the normal lens
108. Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration
109. Neutral retains promote cell division and fibre differentiation in lens epithelial explants
110. Growth factors in the eye
111. Integrins and development: How might these receptors regulate differentiation of the lens
112. An action spectrum for UV-B radiation and the rat lens
113. Differential expression of facilitative glucose transporters GLUT1 and GLUT3 in the lens
114. Apoptosis in the rat lens after in vivo threshold dose ultraviolet irradiation
115. Cell proliferation and displacement in the lens epithelium of young rats injected with tritiated thymidine
116. K-ATPase in rat lens epithelium and fiber cell: Invest
117. Alpha-smooth muscle actin expression in cultured lens epithelial cells
118. Maintenance of the synthesis of αB-crystallin and progressive expression of βBp-crystallin in human fetal lens epithelial cells in culture
119. Human fetal lens epithelial cells in culture: An in vitro model for the study of crystallin expression and lens differentiation
120. αB-crystallin is expressed in kidney epithelial cell lines and not in fibroblasts
121. Lens fiber cell differentiation and expression of crystallins in co-cultures of human fetal lens epithelial cells and fibroblasts
122. The expression of differentiation of chicken lens epithelium in in vitro cell culture
123. Induction of lens differentiation by activation of a βZIP transcription factor
124. Heme oxygenase synthesis is induced in cultured lens epithelium by hypobaric oxygen or puromycin
125. Store depletion and calcium influx
126. Distribution and movement of ions in the ocular lens
127. Comparison of human lens epithelial cells in situ and in vitro in relation to aging: An ultra structural study
128. Lens differentiation in vertebrates: A review of cellular and molecular features
129. Changes in the energy metabolism of cultured lens epithelial cells in comparison with the fresh lens
130. Glutathione peroxidase in lens and a source of hydrogen peroxide in the aqueous humor
131. Dye transfer between cells of the lens
132. Kv3.3 potassium, channels in lens epithelium and corneal endothelium
133. Molecular biology and electrophysiology of calcium-activated channels from lens epithelium
134. Programmed cell death and the control of cell survival: Lessons from the nervous system
135. Immunocytochemical evidence for an actin-myosin system in the lens epithelial cells
136. Molecular identity and calmodulin-mediated regulation of the taurine transporter in a human retinal pigment epithelial cell line
137. Donor age influences the growth of rabbit lens epithelial cells in vitro
138. A forty-two year voyage through vision research
139. Studies on the crystalline lens XII. Turnover of glycine and glutamic acid in glutathione and ophthalmic acid in the rabbit
140. UV-B irradiation alters the activities and kinetic properties of the enzymes of energy metabolism in rat lens during aging
141. Defense systems of the lens against oxidative damage
142. Biochemical changes associated with the development and reversal of galactose cataracts
143. Localization of steady currents in the lens
144. Role of lens epithelium in sugar cataract formation
145. Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice
146. Embryonic lens induction: More than meets the optic vesicle
147. TEMPOL protects against lens DNA strand breaks and cataract in the X-rayed rabbit
148. Identification of SPARC in the anterior lens capsule and its expression by lens epithelial cells
149. Analysis of a-crystallin expression in cultured mouse and rabbit lens cells
150. Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissues
151. Activity of ubiquitin-dependent pathway in response to oxidative stress. Ubiquitin-activating enzyme is transiently up regulated
152. Morphological observations on cell death and phagocytosis induced by ultraviolet irradiation in a cultured human lens epithelial cell line
153. DNA damage and repair in rabbit lens epithelial cells following UVA irradiation
154. State of differentiation of bovine epithelial lens cells in vitro. Relationship between the variation of the cell shape and the synthesis of crystallins
155. Lens epithelium derived growth factor LEDGF: Effects on growth and survival factor of lens epithelial cell, keratinocytes and fi broblasts
156. Oxidative stress-induced cataract: Mechanism of action
157. 2-resistant immortal lens epithelial cell line
158. Uber korrelation in der entwickling des auges
159. A glutathione S-transferase isozyme (bGST5.8) involved in the metabolism of 4-hydroxy-2-transnonenal is localized in bovine lens epithelium
160. The role of corticosteroids in the homeostasis of the eye
161. Mechanisms and genes of cellular suicide
162. Distribution of glucocorticoid and mineralcorticoid receptors and 11 β-hydroxysteroid dehydrogenases in human and rat ocular tissues
163. Lens capsule and epithelium in age-related cataract
164. Veranderungen des linsenepithels bei diabetikern und nichtdiabetikern mit verschiedenen trubungsformen einer altersassoziierten katarakt
165. Differential gene expression in male and female rat lenses undergoing cataract by transforming growth factor-beta (TGF-beta)
166. Human lens cells have in vitro proliferation capacity inversely proportional to the donor age
167. Lens hexokinase deactivation by near-UV irradiation
168. Lens epithelial cell density and histomorphological study in cataractous lenses
169. Cultured calf lens epithelium. 1. Methods of cultivation and characteristics of the cultures
170. Analysis of genomic integrity and p53-dependent G1 checkpoint in Telomerase-induced extended-life span human fibroblasts
171. Glucose regulation of gene transcription
172. Dedifferentiation of lens epithelial cells in tissue culture
173. The transcriptional program in the response of human fibroblasts to serum
174. Lens epithelial cell mRNA. II. Expression of a mRNA encoding a lipid-binding protein in rat lens epithelial cells
175. Water channels and urea transporters
176. Evidence of genotoxic damage in human cataractous lenses
177. Cortical cataract development - An expression of primary damage to the lens epithelium
178. Human lens epithelial cell proliferation in a protein-free medium
179. Hepatocyte growth factor function and c-Met expression in human lens epithelial cells
180. Nuclear degeneration in the developing lens and its regulation by TNF-α
181. Expression and characterization of SPARC in human lens and in the aqueous and vitreous humors
182. Epithelial organization of the mammalian lens
183. Cell cycle regulation in the lens: Proliferation, quiescence, apoptosis and differentiation
184. +/myoinositol cotransporter gene and characterization of an osmotic responsive promoter
185. Lens UV photobiology