Expression of crystallins, Pax6, Filensin, CP49, MIP, and MP20 in lens- derived cell lines

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 10, 1996, Pages 2120-2128

  Krausz, Eberhard ^a   Augusteyn, Robert C ^b   Quinlan, Roy A ^c   Reddan, John R ^d   Russell, Paul ^e   Sax, Christina M ^e   Graw, Jochen ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b NATIONAL VISION RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d OAKLAND UNIVERSITY   (United States)

^e NATIONAL EYE INSTITUTE   (United States)

Author keywords

cell culture; crystallins; cytoskeleton; gene expression; membrane protein

Indexed keywords

ALPHA CRYSTALLIN; BETA CRYSTALLIN; COMPLEMENTARY DNA; CRYSTALLIN; CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; LENS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

AMINO ACID SEQUENCE; ANIMALS; AQUAPORINS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; CRYSTALLINS; DNA; DNA PRIMERS; DNA-BINDING PROTEINS; EYE PROTEINS; GENE EXPRESSION; HOMEODOMAIN PROTEINS; INTERMEDIATE FILAMENT PROTEINS; LENS, CRYSTALLINE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MOLECULAR SEQUENCE DATA; PAIRED BOX TRANSCRIPTION FACTORS; POLYMERASE CHAIN REACTION; RABBITS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 0029741535     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Russell P, Carper DA, Kinoshita JH. Synthesis of gamma crystallin by a cloned cell line from Nakano mouse lens. Invest Ophthalmal Vis Sci. 1978; 17:568-570.
2. Russell P, Fukui HN, Tsunematsu Y, Huang FL, Kinoshita JH. Tissue culture of lens epithelial cells from normal and Nakano mice. Invest Ophthalmol Vis Sci. 1977;16:243-246.
3. Sax CM, Farrell FX, Zehner ZE, Piatigorsky J. Regulation of vimentin gene expression in the ocular lens. Dev Biol. 1990;139:56-64.
4. Reddan JR, Chepelinsky AB, Dziedzic DC, Piatigorsky J, Goldenburg EM. Retention of lens specificity in long-term cultures of diploid rabbit lens epithelial cells. Differentiation. 1986;33:168-174.
5. Meakin SO, Reddan JR, Tsui LC, Breitman ML. A rabbit lens epithelial cell line supports expression of an exogenous crystallin gene characteristic of lens fiber cell differentiation. Exp Eye Res. 1989;48:131-137.
6. Sax CM, Dziedzic DC, Piatigorsky J, Reddan JR. Analysis of α-crystallin expression in cultured mouse and rabbit lens cells. Exp Eye Res. 1995;61:125-127.
7. Yu CCK, Tsui LC, Breitman ML. Homologous and heterologous enhancers modulate spatial expression but not cell-type specificity of the murine γF-crystallin promoter. Development. 1990;110:131-139.
8. Dubin RA, Gopal-Srivastava R, Wawrousek EF, Piatigorsky J. Expression of the murine αB-crystallin gene in lens and skeletal muscle: Identification of a muscle-preferred enhancer. Mol Cell Biol. 1991;9:4340-4349.
9. Sax CM, Ilagan JG, Piatigorsky J. Functional redundancy of the DE-1 and αA-CRYBP1 regulatory sites of the mouse αA-crystallin promotor. Nucl Acids Res. 1993;21:2633-2640.
10. Sax CM, Cvekl A, Kantorow M, et al. Lens-specific activity of the mouse αA-crystallin promoter in the absence of a TATA box: Functional and protein binding analysis of the mouse αA-crystallin PE1 region. Nucl Acids Res. 1995;23:442-451.
11. Yamada T, Nakamura T, Westphal H, Russell P. Synthesis of α-crystallin by a cell line derived from the lens of a transgenic animal. Curr Eye Res. 1990;9:31-37.
12. Nakamura T, Donovan DM, Hamada K, et al. Regulation of the mouse αA-crystallin gene: Isolation of a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. Mol Cell Biol. 1990;10:3700-3708.
13. Halder G, Callaerts P, Gehring WJ. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science. 1995;267:1788-1792.
14. Cvekl A, Kashanchi F, Sax CM, Brady JN, Piatigorsky J. Transcriptional regulation of the mouse αA-crystallin gene: Activation dependent on a cyclic AMP-response element (DE1/CRE) and a Pax-6-binding site. Mol Cell Biol. 1995;15:653-660.
15. Cvekl A, Sax CM, Bresnick EH, Piatigorsky J. A complex array of positive and negative elements regulates the chicken αA-crystallin gene: Involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins. Mol Cell Biol. 1994;14:7363-7376.
16. Richardson J, Cvekl A, Wistow, G. Pax-6 is essential for lens-specific expression of ζ-crystallin. Proc Natl Acad Sci USA. 1995;92:4676-4680.
17. Cvekl A, Sax CM, Li X, McDermott JB, Piatigorsky J. Pax-6 and lens-specific transcription of the chicken δ1-crystallin gene. Proc Natl Acad Sci USA. 1995;92:4681-4685.
18. de Jong WW, Lubsen NH, Kraft HJ. Molecular evolution of the eye lens. Prog Retinal Eye Res. 1994;13:391-442.
19. Greene LA, Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA. 1976;73:2424-2428.
20. Walther C, Gruss P. Pax6, a murine paired box gene, is expressed in the developing CNS. Development. 1991;113:1435-1449.
21. Augusteyn RC, Seifert R, Tai L, Thompsdon CH. Monoclonal antibodies to bovine α-crystallin. Curr Eye Res. 1985;4:13-20.
22. Graw J, Bors W, Gopinath PM, et al. Characterization of Cat-2, a radiation-indiced dominant cataract mutation in mice. Invest Ophthalmol Vis Sci. 1990;31:1353-1361.
23. Bhat SP, Nagineni CN. αB subunit of lens-specific protein α-crystallin is present in other ocular and non-ocular tissue. Biochem Biophys Res Comun. 1989; 158:319-325.
24. Dubin RA, Wawrousek EF, Piatigorsky J. Expression of the murine αB-crystallin gene is not restricted to the lens. Mol Cell Biol. 1989;9:1083-1091.
25. Kato K, Shinohara H, Kurobe N, Goto S, Inaguma Y, Ohshima K. Immunoreactive αA-crystallin in rat non-lenticular tissues detected with a sensitive immunoassay method. Biochim Biophys Acta. 1991;1080:173-180.
26. King CR, Piatigorsky J. Alternative RNA splicing of the murine αA-crystallin gene: Protein-coding information within an intron. Cell. 1983;32:707-712.
27. Srinivasan AN, Nagineni CN, Bhat SP. αA-crystallin is expressed in non-ocular tissues. J Biol Chem. 1992; 267:23337-23341.
28. Piatigorsky, J. Lens crystallins. J Biol Chem. 1992; 267:4277-4280.
29. Yancey SB, Koh K, Chung J, Revel JP. Expression of the gene for main intrinsic polypeptide (MIP): Separate spatial distributions of MIP and β-crystallin gene transcripts in rat lens development. J Cell Biol. 1988; 106:705-714.
30. Mulders JWM, Voorter CEM, Lamers C, et al. MP17, a fiber-specific intrinsic membrane protein from mammalian eye lens. Curr Eye Res. 1988;7:207-219.
31. Kumar NM, Jarvis LJ, Tenbroek E, Louis CF. Cloning and expression of a major rat lens membrane protein, MP20. Exp Eye Res. 1993;56:35-43.
32. Merdes A, Brunkener M, Horstmann H, Georgatos SD. Filensin: A new vimentin-binding, polymerization-competent, and membrane-associated protein of the lens fiber cell. J Cell Biol. 1991;115:397-410.
33. Masaki S, Watanabe T. cDNA sequence analysis of CP94: Rat lens fibre cell beaded-filament structural protein shows homology to cytokeratins. Biochem Biophys Res Comun. 1992;186:190-198.
34. Remington SG. Chicken filensin: A lens fibre cell protein that exhibits sequence similarity to intermediate filament proteins. J Cell Sci. 1993;105:1057-1068.
35. Hess JF, Casselman JT, FitzGerald PG. cDNA analysis of the 49 kDa lens fiber cell cytoskeletal protein: a new, lens-specific member of the intermediate filament family? Curr Eye Res. 1993;12:77-88.
36. Graw J. Genetic aspects of embryonic eye development in vertebrates. Dev Genet. 1996;18:181-197.
37. Strachan T, Read AP. PAX genes. Curr Opin Genet Dev. 1994;4:427-438.
38. Koroma BM, Yang JM, Sundin O. Expression of the Pax-6 homeobox gene in the corneal epithelium and conjunctiva. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1996;37:8453.
39. Hoppenreijs VPT, Pek E, Vrensen GFJM, Treffers WF. Basic fibroblast growth factor stimulates corneal endothelial cell growth and endothelial wound healing of human corneas. Invest Ophthalmol Vis Sci. 1994;35:931-944.
40. Pontén J, Westermark B. Properties of human malignant glioma cells in vitro. Med Biol. 1978;56:184-193.
41. Adams LM, Ethier SP, Ullrich RL. Enhanced in-vitro proliferation and in-vivo tumorigenic potential of mammary epithelium from Balb/c mice exposed in vivo to γ-radiation and/or 7,12-dimethyl-benz[a]anthracen. Cancer Res. 1987;47:4425-4431.
42. Sawada K, Agata J, Eguchi G, Quinlan R, Maisel H. The predicted structure of chick lens CP49 and a variant thereof, CP49ins, the first vertebrate cytoplasmic intermediate filament protein with a lamin-like insertion in helix 1B. Curr Eye Res. 1995;14:545-553.