A critical evaluation of the brain efflux index method as applied to the nitric oxide synthase inhibitor, aminoguanidine

Biopharmaceutics and Drug Disposition

Volumn 22, Issue 9, 2001, Pages 391-401

  Raybon, Joseph J ^a   Boje, Kathleen M K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Aminoguanidine; Blood brain barrier efflux; Blood brain barrier transport; Brain efflux index (BEI) method; Synaptosomal uptake

Indexed keywords

AMINOGUANIDINE; CARBON 14; INULIN; NITRIC OXIDE SYNTHASE INHIBITOR; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN SYNAPTOSOME; BRAIN TISSUE; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENDRITE; DRUG ACCUMULATION; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG RETENTION; DRUG TISSUE LEVEL; DRUG TRANSPORT; DRUG UPTAKE; IN VIVO STUDY; MALE; MICHAELIS MENTEN KINETICS; NERVE CELL; NONHUMAN; NONLINEAR REGRESSION ANALYSIS; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GUANIDINES; INJECTIONS, INTRAVENTRICULAR; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; NITRIC OXIDE SYNTHASE; POLYSACCHARIDES, BACTERIAL; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTOSOMES;

EID: 0035721540     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.285     Document Type: Article

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