Nesprins: A novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues

Journal of Cell Science

Volumn 114, Issue 24, 2001, Pages 4485-4498

  Zhang, Quiping ^a   Skepper, Jeremy N ^a   Yang, Fangtang ^a   Davies, John D ^a   Hegyi, Laszlo ^a   Roberts, Roland G ^a   Weissberg, Peter L ^a   Ellis, Juliet A ^a   Shanahan, Catherine M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Differentiation; Muscle; Nuclear envelope; Nucleus; Spectrin repeats

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENTARY DNA; DYSTROPHIN; EMERIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ISOPROTEIN; LAMIN; LAMININ BINDING PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; NESPRIN 1; NESPRIN 2; NUCLEAR PROTEIN; PROTEIN ANTIBODY; SPECTRIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DNA SEQUENCE; DNA TRANSFECTION; GENE CONSTRUCT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC CODE; GENETIC CONSERVATION; GENETIC IDENTIFICATION; HETEROCHROMATIN; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGOLD STAINING; MOUSE; MUSCLE DEVELOPMENT; MYOBLAST; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RAT; SIMPLE SEQUENCE REPEAT; SKELETAL MUSCLE; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; STRUCTURE ANALYSIS; VASCULAR SMOOTH MUSCLE;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; COS CELLS; DNA, COMPLEMENTARY; HUMANS; IMMUNE SERA; IN SITU HYBRIDIZATION, FLUORESCENCE; MEMBRANE PROTEINS; MICE; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; NERVE TISSUE PROTEINS; NUCLEAR ENVELOPE; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; ORGAN SPECIFICITY; PROTEIN STRUCTURE, TERTIARY; RATS; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE HOMOLOGY, AMINO ACID; SPECTRIN; SUBCELLULAR FRACTIONS;

ANIMALIA;

EID: 0035694555     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Utrophin lacks the rod domain actin binding activity of dystrophin
2. A Syne-1, dystrophin- and klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction
3. Distinct regions specify the targeting of otefin to the nucleoplasmic side of the nuclear envelope
4. Immunoelectron microscopic studies of the intracellular transport of the membrane glycoprotein (G) of vesicular stomatitis virus in infected Chinese hamster ovary cells
5. Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy
6. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy
7. Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy
8. Heart-specific localization of emerin: New insights into Emery-Dreifuss muscular dystrophy
9. Myoferlin, a candidate gene and potential modifier of muscular dystrophy
10. Spectrin tethers and mesh in the biosynthetic pathway
11. Lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics
12. Aberrant intracellular targeting and cell cycle-dependent phosphorylation of emerin contribute to the Emery-Dreifuss muscular dystrophy phenotype
13. The Emery-Dreifuss muscular dystrophy phenotype arises from aberrant targeting and binding of emerin at the inner nuclear membrane
14. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease
15. The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin
16. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation
17. The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain
18. Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope
19. Functional organization of the nuclear envelope
20. Conservation of components of the dystrophin complex in Drosophila
21. kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin
22. Structures of two repeats of spectrin suggest models of flexibility
23. Predicting the orientation of eukaryotic membrane-spanning proteins
24. Vesicle transport: Klarsicht clears up the matter
25. Nuclear targeting signal recognition: A key control point in nuclear transport?
26. mAKAP: An A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes
27. A class of membrane proteins with a C-terminal anchor
28. MAN1, an inner nuclear membrane protein that shares the LEM domain with laminaassociated polypeptide 2 and emerin
29. Molecular analysis of the klarsicht gene and its role in nuclear migration within differentiating cells of the Drosophila eye
30. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B)
31. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
32. The gene for arrhythmogenic right ventricular cardiomyopathy maps to chromosome 14q23-q24
33. Searching for a function for nuclear actin
34. Dystrophins and dystrobrevins
35. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein
36. The intima: Soil for atherosclerosis and restenosis
37. Smooth muscle cell heterogeneity. Patterns of gene expression in vascular smooth muscle cells in vitro and in vivo
38. Isolation of markers of differentiated and proliferating vascular smooth muscle cells
39. Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: Evidence for smooth muscle cell-mediated vascular calcification
40. A tripartite nuclear localization signal in the PDZ-domain protein L-periaxin
41. Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane
42. Kakapo, a novel cytoskeletal-associated protein is essential for the restricted localization of the neuregulin-like factor, vein, at the muscle-tendon junction site
43. Nuclear lamins: Their structure, assembly, and interactions
44. The CLUSTALwindows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
45. Functional diversity of LAP2alpha and LAP2beta in postmitotic chromosome association is caused by an alpha-specific nuclear targeting domain
46. Developmental regulation of vesicle transport in Drosophila embryos: Forces and kinetics
47. The nuclear envelope, muscular dystrophy and gene expression
48. Dystrophin and utrophin: The missing links!
49. Actinin-associated LIM protein: Identification of a domain interaction between PDZ and spectrin-like repeat motifs
50. Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human