Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth

Molecular Microbiology

Volumn 38, Issue 4, 2000, Pages 719-736

  Coers, Jörn ^a,b   Kagan, Jonathan C ^a   Matthews, Miguelina ^a   Nagai, Hiroki ^a   Zuckman, Deborah M ^a   Roy, Craig R ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN;

ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; LYSOSOME; MACROPHAGE; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION;

BACTERIAL PROTEINS; CARRIER PROTEINS; HUMANS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; LYSOSOMES; MACROPHAGES, ALVEOLAR; ORGANELLES;

BACTERIA (MICROORGANISMS); LEGIONELLA PNEUMOPHILA; NEGIBACTERIA;

EID: 0033636197     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.02176.x     Document Type: Article

References (49)

1. Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway
2. Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila
3. Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene
4. Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity
5. Lysosome-associated membrane proteins: Characterization of LAMP-1 of macrophage P388 and mouse embryo 3T3 cultured cells
6. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited
7. Deviant expression of rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate
8. Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth
9. Requirement for exported proteins in secretion through the invasion-associated type III system of Salmonella typhimurium
10. A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis
11. The epidemiology of Legionella pneumophila infections
12. Discovery of virulence genes of Legionella pneumophila by using signature tagged mutagenesis in a guinea pig pneumonia model
13. Charcoal-yeast extract agar: Primary isolation medium for Legionella pneumophila
14. The molecular ecology of Legionellae
15. A novel genetic system to detect protein-protein interactions
16. Legionnaires' disease: Description of an epidemic of pneumonia
17. Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa
18. Identification of macrophage-specific infectivity loci (mil) of Legionella pneumophila that are not required for infectivity of protozoa
19. Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
20. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
21. Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes
22. The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome lysosome fusion in human monocytes
23. Legionnaires' disease bacterium (Legionella pneumophila) multiplies intracellularly in human monocytes
24. Evidence for pore-forming ability by Legionella pneumophila
25. Legionnaires' disease: Isolation of a bacterium and demonstration of its role in other respiratory diseases
26. Identification and subcellular localization of the Legionella pneumophila IcmX protein: A factor essential for establishment of a replicative organelle in eukaryotic host cells
27. Controlling the maturation of pathogen-containing vacuoles: A matter of life and death
28. Analysis of the Legionella pneumophila flil gene: Intracellular growth of a defined mutant defective for flagellum biosynthesis
29. A series of wide-host-range low-copy-number vectors that allow direct screening for recombinants
30. The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex
31. Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection
32. Trafficking of the Legionella pneumophila phagosome
33. Topology of Legionella pneumophila DotA: An inner membrane protein required for replication in macrophages
34. Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake
35. Identification of Legionella pneumophila genes required for growth within and killing of human macrophages
36. Characterization of a new region required for macrophage killing by Legionella pneumophila
37. How is the intracellular fate of the Legionella pneumophila phagosome determined?
38. Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages
39. Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome
40. Safe haven: The cell biology of nonfusogenic pathogen vacuoles
41. A new method of preparing gold probes for multiple-labeling cytochemistry
42. Establishment and characterization of a human histiocytic lymphoma cell line (U-937)
43. Association of Legionella pneumophila with the macrophage endoplasmic reticulum
44. Cell biology of Legionella pneumophila
45. Use of salt to isolate Legionella pneumophila mutants unable to replicate in macrophages
46. Conjugative transfer by the virulence system of Legionella pneumophila
47. Isolation of macrophage/monocyte populations
48. Early events in phagosome establishment are required for intracellular survival of Legionella pneumophlia
49. Poreforming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth