Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2+ and cell proliferation in primary human mammary epithelial cells

Carcinogenesis

Volumn 18, Issue 6, 1997, Pages 1177-1182

  Tannheimer, Stacey L ^a   Barton, Sandra L ^b   Ethier, Stephen P ^c   Burchiel, Scott W ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; BENZO[A]PYRENE; CARCINOGEN; DIMETHYLBENZ[A]ANTHRACENE; EPIDERMAL GROWTH FACTOR; POLYCYCLIC AROMATIC HYDROCARBON;

ARTICLE; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CALCIUM CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; TUMOR PROMOTION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; BENZO(A)PYRENE; BENZOFLAVONES; BREAST; BREAST NEOPLASMS; CALCIUM; CARCINOGENS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPITHELIUM; FEMALE; HOMEOSTASIS; HUMANS; INTRACELLULAR FLUID; POLYCYCLIC HYDROCARBONS, AROMATIC; TETRACHLORODIBENZODIOXIN;

EID: 0031408417     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.6.1177     Document Type: Article

References (40)

1. Pitot, H.C. and Dragan, Y.P. (1996) Chemical carcinogenesis. In Klassen, C.D. (ed.), Casarett and Doull's Toxicology. McGraw-Hill, New York, NY, pp. 201-267.
2. Ethier, S.P. (1985) Primary culture and serial passage of normal and carcinogen-treated rat mammary epithelial cells in vitro. J. Natl Cancer Inst., 74, 1307-1318.
3. Miller, J.A. (1970) Carcinogenesis by chemicals: an overview. Clowes Memorial Lecture. Cancer Res., 30, 559-571.
4. 2+ produced by 7,12-dimethylbenz(a)anthracene (DMBA) in the Jurkat human T cell line. Int. J. Immunopharmacol., 13, 109-115.
5. Davila, D.R., Davis, D.P., Campbell, K., Cambier, J. and Burchiel, S.W. (1995) Role of altered calcium homeostasis and signal transduction in polycyclic aromatic hydrocarbon-induced immunotoxicity in B cells, invited review. J. Toxicol. Environ. Hlth, 45, 101-126.
6. Archuleta, M.M., Schieven, G.L., Ledbetter, J.A., Deanin, G.G. and Burchiel, S.W. (1993) 7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T cell line and increases tyrosine phosphorylation of phospholipase C-γ1, formation of inositol 1,4,5-triphosphate, and mobilization of intracellular calcium. Proc. Natl Acad. Sci. USA, 90, 6105-6109.
7. Krieger, J.A., Davila, D.R., Lytton, J.L., Born, J.L. and Burchiel, S.W. (1993) Inhibition of sarcoplasmic/endoplasmic reticulum calcium-ATPases (SERCA) by polycyclic aromatic hydrocarbons in HPB-ALL human T cells and other tissues. Toxicol. Appl. Pharmacol., 133, 102-108.
8. Stampfer, M.R. and Yaswen, P. (1993) Culture systems for study of human mammary epithelial cell proliferation, differentiation, and transformation. Cancer Surv., 18, 7-34.
9. Ethier, S.P., Kudula, A. and Cundiff, K.C. (1987) Influence of hormone and growth factor interactions on the proliferative potential of normal rat mammary epithelial cells in vitro. J. Cell Physiol., 132, 161-167.
10. Ethier, S.P., Chiodino, C. and Jones, R.F. (1990) Role of growth factor synthesis in the acquisition of insulin/insulin-like growth factor I independence in rat mammary carcinoma cells. Cancer Res., 50, 5351-5357.
11. Aaronson, S.A. (1991) Growth factors and cancer. Science, 254, 1146-1153.
12. Glenney, J.R. (1992) Tyrosine-phosphorylated proteins: mediators of signal transduction from the tyrosine kinases. Biochim. Biophys. Acta, 1134, 113-127.
13. 2+ signaling induced by the activation of the epidermal growth factor and nerve growth factor receptors. J. Biol. Chem., 271, 30505-30509.
14. Cole, K. and Kohn, E. (1994) Calcium-mediated signal transduction: biology, biochemistry, and therapy. Cancer Metastasis Rev., 13, 31-44.
15. Trump, B.F. and Berzesky, I.K. (1987) Ion regulation, cell injury and carcinogenesis. Carcinogenesis, 8, 1027-1031.
16. Slaga, T.J., Fischer, S.M., Weeks, C.E., Klein-Szanto, A.J.P. and Reiners, J. (1982) Studies on the mechanism involved in multistage carcinogenesis in mouse skin. J. Cell Biochem., 18, 99-119.
17. Whitfield, J.E. Boynton, A.L. McManus, J.P. Rixon, R.H., Sikorska, M. Tsang, B., Walker, P.R. and Swierenga, S.H. (1981) The role of calcium and cAMP in cell proliferation. Annls NY Acad. Sci., 339, 216-240.
18. Durham, A.C. and Walton, J.M. (1982) Calcium ions and the control of proliferation in normal and cancer cells. Biosci. Rep., 2, 15-30.
19. Ethier, S.P., Mahacek, M.L., Gullick, W.J., Frank, T.S. and Weber, B.L. (1993) Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media Cancer Res., 53, 627-635.
20. Novak, E.J. and Rabinovitch, P.S. (1994) Improved sensitivity in flow cytometric intracellular ionized calcium measurement using Fluo-3/Fura-Red fluorescence ratios. Cytometry, 17, 135-141.
21. Scudiero, D.A., Shoemaker, R.H., Paull, K.D., Monks, A., Tierney, S., Nofziger, T.H., Currens, M.J., Seniff, D. and Boyd, M.R. (1988) Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res., 48, 4827-4833.
22. Thakker, D.R., Yagi, H., Levin, W., Wood, A.W., Conney, A.H. and Jerina, D.M. (1985) Polycyclic aromatic hydrocarbons: metabolic activation to ultimate carcinogens. Bioactive Foreign Compounds, 7, 177-242.
23. Nebert, D.W. (1989) The Ah locus: genetic differences in toxicity, cancer, mutation and birth defects. Crit. Rev. Toxicol., 20, 153-174.
24. El-Bayoumy, K. (1992) Environmental carcinogens that may be involved in human breast cancer etiology. Chem. Res. Toxicol., 5, 585-590.
25. Heidelberger, C. (1975) Chemical carcinogenesis. Annu. Rev. Biochem., 44, 79-121.
26. Dipple, A. (1994) Reactions of polycyclic aromatic hydrocarbons with DNA. IARC Sci. Publ., 125, 107-129.
27. Stampfer, M.R., Bartholomew, J.C., Smith, H.S. and Bartley, J.C. (1981) Metabolism of benzo[a]pyrene by human mammary epithelial cells: toxicity and DNA adduct formation. Proc. Natl Acad. Sci. USA, 78, 6251-6255.
28. Bartley, J., Bartholomew, J.C. and Stampfer, M.R. (1982) Metabolism of benzo[a]pyrene by human epithelial and fibroblastic cells: metabolite patterns and DNA adduct formation. J. Cell Biochem., 18, 135-148.
29. Leadon, S.A., Stampfer, M.R. and Bartley, J. (1988) Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing. Proc. Natl Acad. Sci. USA, 85, 4365-4368.
30. Gould, M.N., Grau, D.R., Seidman, L.A. and Moore, C.J. (1986) Interspecies comparison of human and rat mammary epithelial cell-mediated mutagenesis by polycyclic aromatic hydrocarbons. Cancer Res., 46, 4942-4945.
31. Davis, D.P. and Burchiel, S.W. (1992) Inhibition of calcium-dependent pathways of B-cell activation by DMBA. Toxicol. Appl. Pharmacol., 116, 202-208.
32. Carpenter, G. and Cohen, S. (1990) Epidermal growth factor. J. Biol. Chem., 265, 7709-7712.
33. Ullrich, A. and Schlessinger, J. (1990) Signal transduction by receptors with tyrosine kinase activity. Cell, 61, 203-212.
34. Krieger, J.A., Born, J.L. and Burchiel, S.W. (1994) Persistence of calcium elevation in the HPB-ALL T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons. Toxicol. Appl. Pharmacol., 127, 268-274.
35. Burchiel, S.W., Davis, D.P., Ray, S.D. and Barton, S.L. (1993) DMBA induces programmed cell death (apoptosis) in the A20.1 murine B cell lymphoma. Fundam. Appl. Toxicol., 21, 120-124.
36. 2+ stores by specific inhibition of the endoplasmic reticulum ATPase. Proc. Natl Acad. Sci. USA, 87, 2466-2470.
37. Sewall, C.H., Lucier, G.W., Tritscher, A.M. and Clark, G.C. (1993) TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD. Carcinogenesis 14, 1885-1893.
38. Fernandez, P. and Safe, S. (1991) Growth inhibitory and antimitogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in T47D human breast cancer cells. Toxicol. Lett., 61, 185-197.
39. Gierthy, J.F., Bennett, J.A., Bradley, L.M. and Cutler, D.S. (1993) Correlation of in vitro and in vivo growth suppression of MCF-7 human breast cancer by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Res., 53, 3149-3153.
40. Liu, H., Biegel, L., Narasimhan, T.R., Rowlands, C. and Safe, S. (1992) Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Mol. Cell. Endocrinol., 87, 19-28.