Both (±)syn- and (±)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at codon 61 of c-H-ras1

Cancer Research

Volumn 60, Issue 20, 2000, Pages 5688-5695

  Tang, Moon Shong ^a   Vulimiri, Suryanarayana V ^b   Viaje, Aurora ^c   Chen, James X ^a   Bilolikar, Deepa S ^a   Morris, Rebecca J ^d   Harvey, Ronald G ^e   Slaga, Tom J ^c   DiGiovanni, John ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; 7,12 DIMETHYLBENZ(A)ANTHRACENE 3,4 DIHYDRODIOL; 7,12 DIMETHYLBENZ(A)ANTHRACENE DNA ADDUCT; 7,12-DIMETHYLBENZ(A)ANTHRACENE-3,4-DIHYDRODIOL; 7,12-DIMETHYLBENZ(A)ANTHRACENE-DNA ADDUCT; CARCINOGEN; DNA; DRUG DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CODON; CONTROLLED STUDY; DNA ADDUCT; FEMALE; GENE MUTATION; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; SKIN CANCER; SKIN PAPILLOMA; ANIMAL; BIOTRANSFORMATION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; EPIDERMIS; GENETICS; METABOLISM; MUTATION; ONCOGENE RAS; PAPILLOMA; SENSITIVE TO CARCINOGENESIS MOUSE; SKIN TUMOR; STEREOISOMERISM;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; BIOTRANSFORMATION; CARCINOGENS; CODON; DNA; DNA ADDUCTS; EPIDERMIS; FEMALE; GENES, RAS; MICE; MICE, INBRED SENCAR; MUTATION; PAPILLOMA; SKIN NEOPLASMS; STEREOISOMERISM;

EID: 0034666847     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

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2. Products of binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse skin
3. Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-mice
4. Kinetics of formation and disappearance of 7,12-dimethylbenz[a]anthracene: DNA adducts in mouse epidermis
5. Dimethylbenz[a]anthracene-DNA binding in mouse skin: Response of different mouse strains and effects of various modifiers of carcinogenesis
6. Variation in route of microsomal activation of 7,12-dimethylbenz[a]anthracene with substrate concentration
7. Limitations of metabolic activation systems used with in vitro tests for carcinogens
8. Additional evidence for the involvement of the 3,4-diol 1,2-oxides in metabolic activation of 7,12-dimethylbenz[a]anthracene in mouse skin
9. Involvement of both syn- and anti-dihydrodiol epoxides in the binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse embryo cell cultures
10. Absolute stereochemistry of the major 7,12-dimethylbenz[a]anthracene-DNA adducts formed in mouse cells
11. Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas
12. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
13. Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo
14. Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons
15. Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]anthracene-induced hamster skin tumors
16. Activating mutation of the Ha-ras gene in chemically induced tumors of the hamster cheek pouch
17. Oncogene activation in chemical carcinogenesis
18. An experimental analysis of cancer: Role of ras oncogenes in multistep carcinogenesis
19. Ras genes
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22. Using UvrABC nuclease to detect 7,12-dimethylebenz(a)anthracene-anti-diol epoxide DNA binding specificity in the mouse H-ras gene
23. Mechanism of metabolic activation of the potent carcinogen 7,12-dimethylbenz[a]anthracene
24. Identification and quantitation of 7,12-dimethylbenz[a]anthracene-DNA adducts formed in mouse skin
25. Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: The role of apurinic sites
26. Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites
27. Synthesis of the active diol epoxide metabolite of the potent carcinogenic hydrocarbon 7,12-dimethylbanz[a]anthracene
28. Repair of benzo(a)pyrene diol epoxide and UV induced DNA damage at the adenine phosphoribosyl transferase gene and amplified dihydrofolate reductase gene in Chinese hamster ovary cells detected by UvrABC nuclease
29. Relationship between chemically induced Ha-ras mutation and transformation of BALB/c 3T3 cells: Evidence for chemical-specific activation and cell type-specific recruitment of oncogene in transformation
30. Detection of dibenzo[a, l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR-RFLP method
31. Covalent DNA adducts formed in mouse epidermis from dibenz[a, j]anthracene: Evidence for the formation of polar adducts
32. 32P-postlabeling test for structurally diverse DNA adducts
33. 32P-postlabeling and high pressure liquid chromatographic analyses for 7,12-dimethylbenz[a]anthracene-DNA adducts
34. 32P-postlabeled 7,12-dimethylbenzanthracene-DNA adducts
35. Evidence that binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse embryo cell cultures results in extensive substitution of both adenine and guanine residues
36. Chromatographic and fluorescence spectroscopic studies of individual 7,12-dimethylbenz[a]anthracene-deoxyribonucleside adducts
37. Distribution, covalent binding, and DNA adduct formation of 7,12-dimethylbenz[a]anthracene in SENCAR and BALB/c mice following topical and oral administration
38. Benzo(e)pyrene-induced alterations in the binding of benzo(a)pyrene and 7,12-dimethylbenz[a]anthracene to DNA in SENCAR mouse epidermis
39. 7,12-Dimethylbenz[a]anthracene that reacts predominantly with adenine residues in DNA
40. Mouse skin tumor initiating activity of fluorinated derivatives of 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene
41. Comparative metabolism in vitro of a novel carcinogenic polycyclic aromatic hydrocarbon, 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene, and its two regioisomeric B-ring fluoro analogues
42. Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen
43. Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice
44. Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels
45. Quantitation of early clonal expansion of two mutant 61(st) codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP