The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-κB targeting in the alveolar epithelium

British Journal of Pharmacology

Volumn 133, Issue 1, 2001, Pages 49-60

  Haddad, J J E ^a   Safieh Garabedian, B ^b   Saade N E ^b   Land, S C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Cytokines; Endotoxin; IL 10; Immunopharmacology; I B ; NF B; Pathophysiology

Indexed keywords

ACETAMIDE DERIVATIVE; DNA; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; N [1 [4 [[4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL]METHYL]PHENYL]CYCLOPROPYL]ACETAMIDE; PIPERAZINE DERIVATIVE; PROTEIN; PROTEIN P50; PROTEIN P68; PROTEIN P75; PYRIMIDYLPIPERAZINE; RECOMBINANT INTERLEUKIN 10; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; Y 40138;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOSYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; FETUS; IMMUNOREGULATION; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION;

EID: 0034994153     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704041     Document Type: Article

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