A novel anti-rheumatic drug suppresses tumor necrosis factor-α and augments interleukin-10 in adjuvant arthritic rats

European Journal of Pharmacology

Volumn 409, Issue 3, 2000, Pages 331-335

  Hisadome, Masao ^a   Fukuda, Tetsuko ^a   Sumichika, Hiroshi ^a   Hanano, Tokushi ^a   Adachi, Kunitomo ^a  

^a Welfide Corporation   (Japan)

Author keywords

Arthritis; Interleukin 10; Lipopolysaccharide; TNF (Tumor necrosis factor ); Y 39041

Indexed keywords

ANTIRHEUMATIC AGENT; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 10; INTERLEUKIN 6; N [1 [4 [[4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL]METHYL]PHENYL]CYCLOPROPYL]ACETAMIDE; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; Y 39041;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS;

ACETAMIDES; ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, EXPERIMENTAL; DRUG EVALUATION, PRECLINICAL; HINDLIMB; INTERLEUKIN-10; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; PIPERAZINES; RATS; RATS, INBRED LEW; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034672453     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00866-9     Document Type: Article

References (16)

1. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
2. Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNFα processing
3. Role of cytokines in rheumatoid arthritis
4. Interleukin-10 inhibits cytokine production by activated macrophages
5. A novel dual regulator of tumor necrosis factor-α and interleukin-10 protects mice from endotoxin-induced shock
6. Cellular adhesion molecules in rat adjuvant arthritis
7. Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-α suppression and IL-10 augmentation
8. How Canadians and US rheumatologists treat moderate or aggressive rheumatoid arthritis; a survey
9. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
10. Methotrexate specially modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): A mechanism for methotrexate-mediated immunosuppression
11. Therapeutic potential and strategies for inhibiting tumor necrosis factor-α
12. Differential effects of pentoxifylline on the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 by monocytes and T cells
13. Elevated levels of TNF in the joints of adjuvant arthritic rats
14. Multiple doses of intravenous interleukin-10 in steroid-refractory Crohn's disease
15. Interleukin-10 inhibition of the progression of established collagen-induced arthritis
16. Differential effects of methotrexate and liposomally conjugated methotrexate in rat adjuvant-induced arthritis