Engineering of complex polyketide biosynthesis - Insights from sequencing of the monensin biosynthetic gene cluster

Journal of Industrial Microbiology and Biotechnology

Volumn 27, Issue 6, 2001, Pages 360-367

  Leadlay, P F ^a   Staunton, J ^a   Oliynyk, M ^a   Bisang, C ^a   Cortes J ^c   Frost, E ^a   Hughes Thomas, Z A ^a   Jones, M A ^a   Kendrew, S G ^e   Lester, J B ^a   Long, P F ^d   McArthur, H A ^b   McCormick, E L ^b   Oliynyk, Z ^a   Stark, C B ^a   Wilkinson, C J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PFIZER INC   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d UNIVERSITY OF LONDON   (United Kingdom)

^e BIOTICA TECHNOLOGY LTD   (United Kingdom)

Author keywords

Antibiotic biosynthesis; Monensin; Polyether; Polyketide synthase

Indexed keywords

ERYTHROMYCIN; IONOPHORE; MACROLIDE; MONENSIN; POLYETHER; POLYKETIDE; POLYKETIDE SYNTHASE; RAPAMYCIN;

ACTINOMYCES; ARTICLE; BIOSYNTHESIS; BIOTECHNOLOGY; CATALYSIS; CHEMICAL BOND; COMPLEX FORMATION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; GENE SEQUENCE; ISOMERISM; NONHUMAN;

BIOTECHNOLOGY; GENES, BACTERIAL; MONENSIN; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; PROTEIN ENGINEERING; SEQUENCE ANALYSIS, DNA; STREPTOMYCES;

ACTINOBACTERIA (CLASS); ACTINOMYCES;

EID: 0035675996     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jim.7000204     Document Type: Article

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