Mechanisms of aldosterone's action on epithelial Na+ transport

Journal of Membrane Biology

Volumn 184, Issue 3, 2001, Pages 313-319

  Eaton, D C ^a   Malik, B ^a   Saxena, N C ^a   Al Khalili, O K ^a   Yue, G ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSYLHOMOCYSTEINASE; ALDOSTERONE; GUANINE NUCLEOTIDE BINDING PROTEIN; METHYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; SODIUM CHANNEL;

ANIMAL CELL; EPITHELIUM CELL; GENE ACTIVATION; HORMONAL REGULATION; HORMONE ACTION; METHYLATION; NONHUMAN; ONCOGENE K RAS; ONCOGENE RAS; PROTEIN EXPRESSION; REVIEW; SODIUM ABSORPTION; SODIUM BALANCE; SODIUM TRANSPORT;

ALDOSTERONE; ANIMALS; ANURA; BIOLOGICAL TRANSPORT; CELL MEMBRANE; ELECTRIC CONDUCTIVITY; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNEL; GTP-BINDING PROTEINS; NA(+)-K(+)-EXCHANGING ATPASE; PATCH-CLAMP TECHNIQUES; SODIUM; SODIUM CHANNELS;

ANIMALIA; VERTEBRATA;

EID: 0035671191     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-001-0098-x     Document Type: Review

References (53)

1. Aldosterone induces fas methylation in A6 epithelia
2. The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes
3. Steroid hormone-dependent expression of blocker-sensitive ENaCs in apical membranes of A6 epithelia
4. Methylation increases the open probability of the epithelial sodium channel in A6 epithelia
5. + channels
6. + transport
7. Hormonal regulation of ENaCs: Insulin and aldosterone
8. Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption
9. Epithelial sodium channel related to proteins involved in neurode-generation
10. + channel is made of three homologous subunits
11. Phosphoinositide kinases
12. Epithelial sodium channel regulated by aldosterone-induced protein sgk
13. S-Adenosylmethionine and methylation
14. + across frog skin epithelium by means of presteady-state flux ratio
15. Activation of epithelial Na channels during short-term Na deprivation
16. Feedback regulation of Na channels in rat CCT IV. Mediation by activation of protein kinase C
17. Phosphoinositide kinases
18. 2 and hydrogen ions on active Na transport in the isolated frog skin
19. Epithelial sodium channels: Function, structure, and regulation
20. Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia
21. + channels in the amphibian cell line A6
22. Cell surface expression and turnover of the alpha subunit of the epithelial sodium channel
23. + channels in A6 cells, a regulatory role for protein kinase C
24. Role of Nedd4 and ubiquitination in epithelial sodium channel degradation in native renal A6 cells
25. ENaC degradation in A6 Cells by the ubiquitin-proteasome proteolytic pathway
26. Effects of vasopressin and cAMP on single amiloride-blockable Na channels
27. β-ENaC mRNA and protein levels increase in A6 cells following long-term but not short-term exposure to aldosterone
28. + channels
29. LY-294002-inhibitable PI 3-kinase and regulation of baseline rates of Na(+) transport in A6 epithelia
30. Role of SGK in mineralocorticoid-regulated sodium transport
31. Carboxylmethylation of the β subunit of xENaC regulates channel activity
32. Regulation of the epithelial sodium channel (ENaC) by accessory proteins
33. Ubiquitination and endocytosis of plasma membrane proteins: Role of Nedd4/Rsp5p family of ubiquitin-protein ligases
34. Methylation increases sodium transport into A6 apical membrane vesicles: Possible mode of aldosterone action
35. Aldosterone-induced and GTP-stimulated methylation of a 90-kDa polypeptide in the apical membrane of A6 epithelia
36. Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia
37. + channel by Nedd4 and ubiquitination
38. + channel (ENaC) by ubiquitination
39. WW domains
40. + channel (ENaC)
41. Regulation of ENaC by the extracellular signaling-regulated kinase (ERK/MAPK) cascade
42. + transport
43. + channel subunit proteins
44. + absorption
45. + reabsorption by the aldosterone-induced small G protein K-Ras2A
46. Cellular signaling: Pivoting around PDK-1
47. Relationship between osmotic reactions and active sodium transport in frog skin epithelium
48. Transport of electrolytes and water across epithelia
49. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin
50. The effect of aldosterone on the isolated frog skin epithelium (R. temporaria)
51. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport
52. Structure and function of phosphoinositide 3-kinases
53. Identification of phosphotidylinositol 4,5-bisphosphate binding sites from epithelial sodium channels in A6 cells