Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin

Research in Experimental Medicine

Volumn 198, Issue 2, 1998, Pages 93-99

  Berkarda, Bülent ^a   Koyuncu, Hülya ^b   Soybir, Gürsel ^c,d   Baykut, Fikret ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c Taksim State Hospital   (Turkey)

^d Kaptanpasa Mah Ziya Turkkan Cad   (Turkey)

Author keywords

Hesperidin; Mice; Skin tumorigenesis

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; FLAVONOID; HESPERIDIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; POLYCYCLIC AROMATIC HYDROCARBON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN TUMOR; SUBCUTANEOUS DRUG ADMINISTRATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOGENS; DRUG ANTAGONISM; FEMALE; HESPERIDIN; MICE; NEOPLASMS, EXPERIMENTAL; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 0031666252     PISSN: 03009130     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004330050093     Document Type: Article

References (26)

1. Singleton VL (1981) Naturally occurring food toxicants:phenolic substances of plant origin common in risk foods. Adv Food Res 27:149-242
2. Nakadate T, Yamamoto S, Aizu E, Kato R (1984) Effect of flavonoids and untioxidants on 12-0-tetradecanoylphorbol-13-acetate caused epidermal ornithin decarboxylase induction and tumor promotion in relation to lypoxygenase inhibition by these compounds. Gann 75:214-222
3. Kato R, Nakadate T, Yamamoto S, Sugimura T (1985) Inhibition of 12-0 telradecanoyl-phorbol-13-acetate induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition Carcinogenesis 4:1301-1305
4. Bresnick E, Birt D (1988) Inhibitory effects of the flavonoid, apigenin, on epidermal ornithine decarboxylase and mouse skin tumorigenesis. Proc Am Assoc Cancer Res 29:136
5. Lasker JM, Huang MT, Conney AH (1984) In vitro and in vivo activation of oxidative drug metabolism by flavonoids. J Pharm Exp Ther 229:162-170
6. Huang MT, Wood AW, Newmark HL, Sayer J, Yagi H, Jerina DM, Conney AH (1983) Inhibition of the mutagenicity of by-region diol-epoxides of polycyclic aromatic hydrocarbon by phenolic plantflavonoids. Carcinogenesis 4:1631-1637
7. Verma AK, Johnson JA, Gould MN, Tanner MA (1988) Inhibition of 7,12-dimethyl-benz(a)anhracene and N-nitrosomethylureo-flavand quercetin. Cancer Res 48:5754-5758
8. Rengün A, Baykut F, Kayahan R, Berkarda B, Öz F et al (1981) Preliminary report on the effect of grapefruit (citruis paradise) extract on erlich ascites cells (EAT). Chim Acta Turc 9:25
9. Baykut F, Benliodlu G, Baykut G (1986) Photocatalytic production of ascorbic acid. A secondary photosynthesis in plants. In: Pelizzetti E, Serpone ND (eds) Homogenous and heterogeneous photocatalysis. Reidel Publishing, New York, pp 161-173
10. Brown JP (1980) A review of the genetic effects of naturally occurring flavonoids anthraquinones and related compounds. Mutation Res 75:243-277
11. Torel J, Cillard J, Cillard P (1986) Antioxydant activity of flavonoids and reactivity with peroxy radical. Photochemistry 25(2):383-385
12. Husain SR, Cillard J, Cillard P (1987) Hydroxyl radical scavenging activity of flavonoids. Photochemistry 26(9):2489-2491
13. Canada AT, Giannella E, Nguyen TD, Mason RP (1990) The production of reactive oxygen species by dietary flavonols. Free Radic Biol Med 9:441-449
14. Busse WW, Kopp DE, Middleton E (1984) Flavonoid modulation of human neutrophil function. J Allergy Clin Immunol 73:810
15. Lonchampt M et al (1989) Protective effect of a purified flavonoid fraction against reactive oxygen radicals. Arzneimittelforschung/Drug Research 39(11-8):882-885
16. Botwell RK (1974) The function and mechanism of promoters of carcinogenesis. CRC Crit Rev Toxicol 2:419-443
17. Wertz ED (1986) Mn:Relationship between cellular Superoxide dismutase and susceptibility to chemically induced cancer in the rat mammary gland. Carcinogenesis 70: 1197-1201
18. Cerutti PA (1985) Prooxidant states and tumor promotion. Science 227:375-385
19. Nygard OF, Simic MG (1983) Radio protectors and anticarcinogens. Academic Press, New York, p 471
20. Dionisi D, Galeotti T, Terranove T, Azzi A (1975) Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues. Biochem Biophys Acta 402:292-300
21. Kiliç K (1986) Oxygen radicals and superoxide dismutase in cancer. Biokimya 11(3):59-76
22. Perchellet JP, Perchellet EM (1989) Antioxidants and multistage carcinogenesis in mouse skin. Free Radic Biol Med 7:377-408
23. Kensler TW, Taffe B (1986) Free radicals in tumor promotion. Adv Free Radic Biol Med 2:347-387
24. Middleton E, Kandaswami C (1992) Effects of flavonoids on immune and inflammatory cell functions. Biochem Pharmacol 43(6):1167-1179
25. Baykut F, Baykut D, Baykut G (1989) Failure of the electron transfer mechanism in cancer development. Int J Exp Clin Chemother 2:76-86
26. Baykut S, Atun G (1987) Investigation of redox characters of some organic substanc-es by using electrochemical and photochromotographic methods. Chim Acta Turc 15:180-201