Bcl-2 increases emptying of endoplasmic reticulum Ca2+ stores during photodynamic therapy-induced apoptosis

Cell Calcium

Volumn 30, Issue 5, 2001, Pages 343-350

  Granville, D J ^a,b   Ruehlmann, D O ^a   Choy, J C ^a   Cassidy, B A ^b   Hunt, D W C ^b   Van Breemen, C ^a   McManus, B M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b QLT Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BENZOPORPHYRIN DERIVATIVE; CALCIUM ION; CASPASE; IONOMYCIN; IONOPHORE; PHOTOSENSITIZING AGENT; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; CULTURE MEDIUM; ENDOPLASMIC RETICULUM; ENZYME DEGRADATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM;

EID: 0035666902     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1054/ceca.2001.0243     Document Type: Article

References (36)

1. Photodynamic therapy: Shedding light on the biochemical pathways regulating porphyrin-mediated cell death
2. Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8 and 9 during endothelial cell apoptosis
3. Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy
4. Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy
5. Nuclear factor-κB activation by the photochemotherapeutic agent verteporfin
6. Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer: Bcl-2 and Bcl-xL overexpression do not prevent early mitochondrial events but activity
7. Photodynamic action of porphyrin on Ca2+ influx in endoplasmic reticulum: A comparison with mitochondria
8. Effects of BAPTA-AM and forskolin on apoptosis and cytochrome c release in photosensitized Chinese hamster V79 cells
9. Oxidative stress impairs the function of sarcoplasmic reticulum by oxidation of sulfhydryl groups in the Ca2+-ATPase
10. Inhibition of Ca(2+)-ATPase of vascular smooth muscle sarcoplasmic reticulum by reactive oxygen intermediates
11. Sarco(endo)plasmic reticulum Ca2+ pump isoform SERCA3 is more resistant than SERCA2b to peroxide
12. A 14;18 and a 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia
13. Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation
14. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance
15. Apoptosis: Molecular aspects of cell death and disease
16. Mitochondria and apoptosis
17. Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts
18. Protection against hydrogen peroxide cytotoxicity in rat-1 fibroblasts provided by the oncoprotein Bcl-2: Maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathione
19. Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2
20. Modulation of endoplasmic reticulum calcium pump by Bcl-2
21. Apoptosis in insulin-secreting cells. Evidence for the role of intracellular ca2+ stores and arachidonic acid metabolism
22. Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions
23. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
24. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
25. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. Apoptosis induction by the photosensitizer verteporfin: Identification of mitochondrial adenine nucleotide translocator as a critical target
28. Mitochondrial release of apoptosis inducing factor (AIF) and cytochrome c during smooth muscle cell apoptosis
29. BPD-MA-mediated photosensitization in vitro and in vivo: Cellular adhesion and beta 1 integrin expression in ovarian cancer cells
30. Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats
31. Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system
32. Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase
33. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2 and PAF
34. The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
35. Effects of BAPTA-AM and forskolin on apoptosis and cytochrome c release in photosensitized Chinese hamster V79 cells