CD27 expression in the human splenic marginal zone: The infant marginal zone is populated by naive B cells

Tissue Antigens

Volumn 58, Issue 4, 2001, Pages 234-242

  Zandvoort, A ^a   Lodewijk, M E ^a   De Boer, N K ^a   Dammers, P M ^a   Kroese, F G M ^a   Timens, W ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

B cells; CD27; Human; Infant; Marginal zone; Spleen

Indexed keywords

ALPHA ACTIN; CD27 ANTIGEN; CD3 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY;

ADOLESCENT; ADULT; AGE; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CHILD; CHILD DEVELOPMENT; CONTROLLED STUDY; FROZEN SECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; LYMPHOCYTE COUNT; MEMORY CELL; NEWBORN; PRIORITY JOURNAL; SECONDARY IMMUNE RESPONSE; SPLEEN;

ADOLESCENT; ADULT; ANTIGENS, CD27; B-LYMPHOCYTES; CHILD, PRESCHOOL; GENE EXPRESSION; HUMANS; IMMUNOLOGIC MEMORY; INFANT; INFANT, NEWBORN; LYMPHOCYTE SUBSETS; RECEPTORS, COMPLEMENT 3D; SPLEEN;

EID: 0035661183     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2001.580403.x     Document Type: Article

References (40)

1. The development of antibody responses in the infant
2. Immuno-architecture of human fetal lymphoid tissues
3. Fetal and neonatal development of human spleen: An immunohistological study
4. Immaturity of the human splenic marginal zone in infants: Possible contribution to the deficient infant immune response
5. Human marginal zone B cells are not an activated B-cell subset: Strong expression of CD21 as a putative mediator for rapid B-cell activation
6. Human immune response to pneumococcal polysaccharides: Complement-mediated localization preferentially on CD21-positive splenic marginal zone B cells and follicular dendritic cells
7. Splenic dependence of the antibody response to thymus-independent (TI-2) antigens
8. Role of CR2 in the human adult and neonatal in vitro antibody response to type 4 pneumococcal polysaccharide
9. Expression and functional characteristics of the complement receptor type 2 on adult and neonatal B lymphocytes
10. In vitro complement-dependent binding and in vivo kinetics of pneumococcal polysaccharide TI-2 antigens in the rat spleen marginal zone and follicle
11. Pneumococcal polysaccharide immunization in infants and children
12. Identification of functional human splenic memory B cells by expression of CD148 and CD27
13. CD27: A memory B-cell marker
14. Memory B cells and CD27
15. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
16. Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells
17. Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion
18. The species-specific structure of microanatomical compartments in the human spleen: Strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone
19. B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production
20. Somatic hypermutation of immunoglobulin genes in human neonates
21. Somatic mutation of immunoglobulin V(H)6 genes in human infants
22. Immunologic priming by one dose of Haemophilus influenzae type b conjugate vaccine in infancy
23. Germinal center reaction and B lymphocytes: Morphology and function
24. Generation of memory B cells and plasma cells in vitro
25. Triple check for antigen specificity of B cells during germinal centre reactions
26. Plasma cell generation from B-lymphocytes via CD27/CD70 interaction
27. CD27/CD70 interaction directly drives B cell IgG and IgM synthesis
28. CD40 ligand is expressed and functional on activated neonatal T cells
29. Cells in the marginal zone of the spleen
30. Human marginal-zone B cells
31. Immunohistochemical localization of smooth muscle myosin in human spleen, lymph node, and other lymphoid tissues. Unique staining patterns in splenic white pulp and sinuses, lymphoid follicles, and certain vasculature, with ultrastructural correlations
32. Characterization of stromal cells with myoid features in lymph nodes and spleen in normal and pathologic conditions
33. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone
34. Most marginal zone B cells in rat express germline encoded Ig V-H genes and are ligand selected
35. Marginal zone B cells respond both to polysaccharide antigens and protein antigens
36. Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zones
37. B cell memory to thymus-independent antigens type 1 and type 2: The role of lipopolysaccharide in B memory induction
38. Complement and the immune response
39. T cell-independent antigens type 2
40. T-independent immune response: New aspects of B-cell biology