Somatic mutation of immunoglobulin V(H)6 genes in human infants

Clinical and Experimental Immunology

Volumn 114, Issue 1, 1998, Pages 33-39

  Ridings, J ^a   Dinan, L ^a   Williams, R ^b   Roberton, D ^a   Zola, H ^a,c  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

^c WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

Affinity maturation immunoglobulin genes; Antibody response; Paediatric immunology; Somatic hypermutation; V(H)6

Indexed keywords

ANTIBODY AFFINITY; ANTIBODY RESPONSE; ARTICLE; GENE MUTATION; GENETIC SELECTION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; INFANT; MATURATION; MUTATION RATE; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; IMMUNOGLOBULIN ALPHA-CHAINS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INFANT; MUTATION; VARIATION (GENETICS);

EID: 0031686448     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00694.x     Document Type: Article

References (26)

1. Gathings WE, Kubagawa H, Cooper MD. A distinctive pattern of B cell immaturity in perinatal humans. Immunol Rev 1981; 57:107-26.
2. Wilson CB. Immunologic basis for increased susceptibility of the neonate to infection. J Pediatr 1986; 108:1-12.
3. Holt PG. Postnatal maturation of immune competence during infancy and childhood. Pediatr Allergy Immunol 1995; 6:59-70.
4. Smith RT, Eitzman DV, Catlin ME, Wirtz EO, Miller BE. The development of the immune response. Characterization of the response of the human infant and adult to immunization with salmonella vaccines. Pediatrics 1964; 68:163-83.
5. Rijkers GT, Sanders LA, Zegers BJ. Anti-capsular polysaccharide antibody deficiency states. Immunodeficiency 1993; 5:1-21.
6. Di Sant'Agnese PA. Simultaneous immunization of new-born infants against diphtheria, tetanus, and pertussis. Am J Public Health 1950; 40:674-80.
7. Kurikka S, Kayhty H, Saarinen L, Ronnberg PR, Eskola J, Makela PH. Immunologic priming by one dose of Haemophilus influenzae type h conjugate vaccine in infancy. J Infect Dis 1995; 172:1268-72.
8. Ridings J, Nicholson IC, Goldsworthy W, Haslam R, Roberton DM, Zola H. Somatic hypermutation of immunoglobulin genes in human neonates. Clin Exp Immunol 1997; 108:366-74.
9. Klein U, Kuppers R, Rajewsky K. Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age. J Exp Med 1994; 180:1383-93.
10. van DijkHard I, Soderstrom I, Feld S, Holmberg D, Lundkvist I. Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals. Eur J Immunol 1997; 27:1381-6.
11. Berman JE, Mellis SJ, Pollock R et al. Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO J 1988; 7:727-38.
12. Berman JE, Nickerson KG, Pollock RR et al. VH gene usage in humans: biased usage of the VH6 gene in immature B lymphoid cells. Eur J Immunol 1991; 21:1311-4.
13. Davidkova G, Pettersson S, Holmberg D, Lundkvist I. Selective usage of VH genes in adult human B lymphocyte repertoires. Scand J Immunol 1997; 45:62-73.
14. Logtenberg T, Young FM, Van Es JH, Gmelig Meyling FH, Alt FW. Autoantibodies encoded by the most JH-proximal human immunoglobulin heavy chain variable region gene. J Exp Med 1989; 170:1347-55.
15. Andris JS, Brodeur BR, Capra JD. Molecular characterization of human antibodies to bacterial antigens: utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families. Mol Immunol 1993; 30:1601-16.
16. Settmacher U, Jahn S, Siegel P, von Baehr R, Hansen A. An anti-lipid A antibody obtained from the human fetal repertoire is encoded by VH6-V lambda I genes. Mol Immunol 1993; 30:953-4.
17. Brezinschek HP, Foster SJ, Brezinschek RI, Dorner T, DomiatiSaad R, Lipsky PE. Analysis of the human V-H gene repertoire - differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM(+) and CD5(-)/IgM(+) B cells. J Clin Invest 1997; 99:2488-501.
18. Meek K, Eversole T, Capra JD. Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution. J Immunol 1991; 146:2434-8.
19. Insel RA, Varade WS. Bias in somatic hypermutation of human VH genes. Int Immunol 1994; 6:1437-43.
20. Wagner SD, Neuberger MS. Somatic hypermutation of immunoglobulin genes. Annu Rev Immunol 1996; 14:441-57.
21. Dorner T, Brezinschek HP, Brezinschek RI, Foster SJ, DomiatiSaad R, Lipsky PE. Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J Immunol 1997; 158:2779-89.
22. Jukes TH, King JL. Evolutionary nucleotide replacements of DNA. Nature 1979; 281:605-6.
23. Kaartinen M, Kulp S, Makela O. Characteristics of selection-free mutations and effects of subsequent selection. In: Steele EJ, ed. Somatic mutations in V-regions. Boca Raton: CRC Press, 1991:105-14.
24. Oprea M, Perelson AS. Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts. J Immunol 1997; 158:5155-62.
25. Ohlin M, Borrehaeck CA. Characteristics of human antibody repertoires following active immune responses in vivo. Mol Immunol 1996; 33:583-92.
26. Mortari F, Wang JY, Schroeder HW Jr. Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed C alpha and C gamma repertoires. J Immunol 1993; 150:1348-57.