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Volumn 9, Issue 1, 1997, Pages 27-41

Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone

Author keywords

Antibodies; B cells; CD23 antigen; Marginal zone; Transgenic mice; V(H)81X

Indexed keywords

AUTOANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; LIPOPOLYSACCHARIDE;

EID: 0031053838     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.1.27     Document Type: Article
Times cited : (147)

References (72)
  • 2
    • 0000590741 scopus 로고
    • Genes and antibodies
    • Lederberg, J. 1959. Genes and antibodies. Science 129:649.
    • (1959) Science , vol.129 , pp. 649
    • Lederberg, J.1
  • 4
    • 0015956495 scopus 로고
    • Towards a network theory of the immune system
    • Jerne N. K. 1974. Towards a network theory of the immune system. Ann. Immunol. 125C:373.
    • (1974) Ann. Immunol. , vol.125 C , pp. 373
    • Jerne, N.K.1
  • 5
    • 0020977755 scopus 로고
    • Cellular mechanisms of immunologic tolerance
    • Nossal, J. G. V. 1983. Cellular mechanisms of immunologic tolerance. Annu. Rev. Immunol. 1:33.
    • (1983) Annu. Rev. Immunol. , vol.1 , pp. 33
    • Nossal, J.G.V.1
  • 7
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
    • Nemazee, D. A. and Burki, K. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337:562.
    • (1989) Nature , vol.337 , pp. 562
    • Nemazee, D.A.1    Burki, K.2
  • 8
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radic, M. Z., Erikson, J., Litwin, S. and Weigert, M. 1993. B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 177:1165.
    • (1993) J. Exp. Med. , vol.177 , pp. 1165
    • Radic, M.Z.1    Erikson, J.2    Litwin, S.3    Weigert, M.4
  • 9
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S. L., Russel, D. M. and Nemazee, D. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009.
    • (1993) J. Exp. Med. , vol.177 , pp. 1009
    • Tiegs, S.L.1    Russel, D.M.2    Nemazee, D.3
  • 10
    • 0029553058 scopus 로고
    • Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
    • Chen, C., Nagy, Z., Prak, E. L. and Weigert, M. 1995. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3:747.
    • (1995) Immunity , vol.3 , pp. 747
    • Chen, C.1    Nagy, Z.2    Prak, E.L.3    Weigert, M.4
  • 12
    • 0023252383 scopus 로고
    • Prominent IgM rheumatoid factor production by human cord blood lymphocytes stimulated in vitro with Staphylococcus aureus Cowan I
    • Levinson, A. I., Dalal, N., Hardar, M., Tar, L. and Orlow, M. 1987. Prominent IgM rheumatoid factor production by human cord blood lymphocytes stimulated in vitro with Staphylococcus aureus Cowan I. J. Immunol. 139:2237.
    • (1987) J. Immunol. , vol.139 , pp. 2237
    • Levinson, A.I.1    Dalal, N.2    Hardar, M.3    Tar, L.4    Orlow, M.5
  • 13
    • 8044231593 scopus 로고
    • Selection of the B-1 cell repertoire and natural antibodies
    • Coutinho, A. and Kazatchkine, M. D., eds, Wiley/ Liss, New York
    • Holmberg, D. and Kearney, J. 1994. Selection of the B-1 cell repertoire and natural antibodies. In Coutinho, A. and Kazatchkine, M. D., eds, Autoimmunity: Physiology and Disease, p. 89. Wiley/ Liss, New York.
    • (1994) Autoimmunity: Physiology and Disease , pp. 89
    • Holmberg, D.1    Kearney, J.2
  • 14
    • 0009302121 scopus 로고
    • Idiotypic networks
    • Paul, W. E., ed., Raven Press, New York
    • Kearney, J. F. 1993. Idiotypic networks. In Paul, W. E., ed., Fundamental Immunology 3, p. 887. Raven Press, New York.
    • (1993) Fundamental Immunology , vol.3 , pp. 887
    • Kearney, J.F.1
  • 15
    • 0018095880 scopus 로고
    • High proportion of Ig-producing cells making autoantibody in normal mice
    • Steele, E. J. and Cunningham, A. J. 1978. High proportion of Ig-producing cells making autoantibody in normal mice. Nature 274:483.
    • (1978) Nature , vol.274 , pp. 483
    • Steele, E.J.1    Cunningham, A.J.2
  • 16
    • 0021949689 scopus 로고
    • Hybrids from normal germfree, nude and neonatal mice produce monoclonal antibodies to eight different intracellular structures
    • Underwood, J. R., Pedersen, R. P., Chalmers, P. J. and Toh, B. H. 1985. Hybrids from normal germfree, nude and neonatal mice produce monoclonal antibodies to eight different intracellular structures. Clin. Exp. Immunol. 60:417.
    • (1985) Clin. Exp. Immunol. , vol.60 , pp. 417
    • Underwood, J.R.1    Pedersen, R.P.2    Chalmers, P.J.3    Toh, B.H.4
  • 18
    • 0024378538 scopus 로고
    • A substantial proportion of the adult BALB/c available B cell repertoire consists of multireactive B cells
    • Rousseau, P. G. and Mallett, C. P. 1989. A substantial proportion of the adult BALB/c available B cell repertoire consists of multireactive B cells. Mol. Immunol. 26:993.
    • (1989) Mol. Immunol. , vol.26 , pp. 993
    • Rousseau, P.G.1    Mallett, C.P.2
  • 19
  • 24
    • 0020040257 scopus 로고
    • Naturally occurring antibodies against nine common antigens in human sera
    • Guilbert, B., Dighiero, G. and Avrameas, S. 1982. Naturally occurring antibodies against nine common antigens in human sera. J. Immunol. 128:2779.
    • (1982) J. Immunol. , vol.128 , pp. 2779
    • Guilbert, B.1    Dighiero, G.2    Avrameas, S.3
  • 25
    • 0027524434 scopus 로고
    • Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunogical 'homunculus' of antibodies in normal serum
    • Nobrega, A., Haury, M., Grandien, A., Malanchere, E., Sundblad, A. and Coutinho, A. 1993. Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunogical 'homunculus' of antibodies in normal serum. Eur. J. Immunol. 23:2851.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2851
    • Nobrega, A.1    Haury, M.2    Grandien, A.3    Malanchere, E.4    Sundblad, A.5    Coutinho, A.6
  • 26
    • 0020074533 scopus 로고
    • Naturally occurring antibodies against nine common antigens in human sera. II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies
    • Dighiero, G., Guilbert, G. and Avrameas, S. 1982. Naturally occurring antibodies against nine common antigens in human sera. II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies. J. Immunol. 128:2788.
    • (1982) J. Immunol. , vol.128 , pp. 2788
    • Dighiero, G.1    Guilbert, G.2    Avrameas, S.3
  • 27
    • 0021699786 scopus 로고
    • Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered 'antigen-free' diet
    • Hooijkaas, H., Brenner, R., Pleasants, J. R. and Wostmann, B. S. 1984. Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered 'antigen-free' diet. Eur. J. Immunol. 14:127.
    • (1984) Eur. J. Immunol. , vol.14 , pp. 127
    • Hooijkaas, H.1    Brenner, R.2    Pleasants, J.R.3    Wostmann, B.S.4
  • 29
    • 0025980973 scopus 로고
    • Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
    • Erikson, J., Radic, M. Z., Camper, S. A., Hardy, R. R., Carmack, C. and Weigert, M. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349:331.
    • (1991) Nature , vol.349 , pp. 331
    • Erikson, J.1    Radic, M.Z.2    Camper, S.A.3    Hardy, R.R.4    Carmack, C.5    Weigert, M.6
  • 30
    • 0027182519 scopus 로고
    • Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice
    • Desai, D. D., Krishnan, M. R., Swindle, J. T. and Marion, T. N. 1993. Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice. J. Immunol. 151:1614.
    • (1993) J. Immunol. , vol.151 , pp. 1614
    • Desai, D.D.1    Krishnan, M.R.2    Swindle, J.T.3    Marion, T.N.4
  • 31
    • 0028295478 scopus 로고
    • Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice
    • Milich, D. R., Jones, J. E., Hughes, J. L., Maruyama, T., Price, J., Melhado, I. and Jirik, F. 1994. Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice. J. Immunol. 152:455.
    • (1994) J. Immunol. , vol.152 , pp. 455
    • Milich, D.R.1    Jones, J.E.2    Hughes, J.L.3    Maruyama, T.4    Price, J.5    Melhado, I.6    Jirik, F.7
  • 32
    • 0028928691 scopus 로고
    • Breaking tolerance leads to antibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice
    • Wirth, S., Guidotti, L. G., Ando, K., Schlicht, H.-J. and Chisari, F. V. 1995. Breaking tolerance leads to antibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice. J. Immunol. 154:2504.
    • (1995) J. Immunol. , vol.154 , pp. 2504
    • Wirth, S.1    Guidotti, L.G.2    Ando, K.3    Schlicht, H.-J.4    Chisari, F.V.5
  • 34
    • 0020550887 scopus 로고
    • Studies on natural antibodies and autoantibodies
    • Avrameas, S., Dighiero, G., Lymberi, P. 1983. Studies on natural antibodies and autoantibodies. Ann. Immunol. 134D:103.
    • (1983) Ann. Immunol. , vol.134 D , pp. 103
    • Avrameas, S.1    Dighiero, G.2    Lymberi, P.3
  • 35
    • 8044226279 scopus 로고
    • H81X transgene bearing B cells in fetus and adult: Sites for expansion and deletion in conventional and CD5/B1 cells
    • in press
    • H81X transgene bearing B cells in fetus and adult: sites for expansion and deletion in conventional and CD5/B1 cells. Int. Immunol., in press.
    • (1995) Int. Immunol.
    • Martin, F.1    Chen, X.2    Kearney, J.F.3
  • 36
    • 0021055659 scopus 로고
    • Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein
    • Podegett, R. A., Mount, S. M., Steitz, J. A. and Sharp, P. A. 1983. Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein. Cell 35:101.
    • (1983) Cell , vol.35 , pp. 101
    • Podegett, R.A.1    Mount, S.M.2    Steitz, J.A.3    Sharp, P.A.4
  • 37
    • 0020623463 scopus 로고
    • Protein binding sites are conserved in U1 small nuclear RNA from insects and mammals
    • Wieben, E. D., Madore, S. J. and Pederson, T. 1983. Protein binding sites are conserved in U1 small nuclear RNA from insects and mammals. Proc. Natl Acad. Sci. USA 80:1217.
    • (1983) Proc. Natl Acad. Sci. USA , vol.80 , pp. 1217
    • Wieben, E.D.1    Madore, S.J.2    Pederson, T.3
  • 38
    • 0021919910 scopus 로고
    • Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides
    • Jemmerson, R., Morrow, P. R., Klinman, N. R. and Paterson, Y. 1985. Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides. Proc. Natl Acad. Sci. USA 82:508.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 508
    • Jemmerson, R.1    Morrow, P.R.2    Klinman, N.R.3    Paterson, Y.4
  • 39
    • 0024724288 scopus 로고
    • Early rearrangements of genes encoding murine immunoglobulin κ chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus
    • Lawler, A. M. Kearney, J. F., Kuehl, M. and Gearhart, P. J. 1989. Early rearrangements of genes encoding murine immunoglobulin κ chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus. Proc. Natl Acad. Sci. USA 86:6744.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 6744
    • Lawler, A.M.1    Kearney, J.F.2    Kuehl, M.3    Gearhart, P.J.4
  • 44
    • 0018726056 scopus 로고
    • A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody secreting hybrid cell lines
    • Kearney, J. F., Radbruch, A., Liesegang, B. and Rajewsky, K. 1979. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody secreting hybrid cell lines. J. Immunol. 123:1548.
    • (1979) J. Immunol. , vol.123 , pp. 1548
    • Kearney, J.F.1    Radbruch, A.2    Liesegang, B.3    Rajewsky, K.4
  • 47
    • 0021346615 scopus 로고
    • Allotypic specificities of murine IgD and IgM recognized by monoclonal antibodies
    • Stall, A. M. and Loken, M. R. 1984. Allotypic specificities of murine IgD and IgM recognized by monoclonal antibodies. J. Immunol. 132:787.
    • (1984) J. Immunol. , vol.132 , pp. 787
    • Stall, A.M.1    Loken, M.R.2
  • 49
    • 0028350333 scopus 로고
    • Immunofluorescence analysis of B-cell ontogeny in the mouse
    • Hamilton, A. M., Lehuen, A. and Kearney, J. F. 1994. Immunofluorescence analysis of B-cell ontogeny in the mouse. Int. Immunol. 6:355.
    • (1994) Int. Immunol. , vol.6 , pp. 355
    • Hamilton, A.M.1    Lehuen, A.2    Kearney, J.F.3
  • 51
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal. Biochem. 162:156.
    • (1987) Anal. Biochem. , vol.162 , pp. 156
    • Chomczynski, P.1    Sacchi, N.2
  • 52
    • 0019865787 scopus 로고
    • Marginal zones: The major B cell compartment of rat spleens
    • Kumararatne, D. S., Bazin, H. and MacLennan, I. C. M. 1981. Marginal zones: the major B cell compartment of rat spleens. Eur. J. Immunol. 11:858.
    • (1981) Eur. J. Immunol. , vol.11 , pp. 858
    • Kumararatne, D.S.1    Bazin, H.2    MacLennan, I.C.M.3
  • 53
    • 0025951891 scopus 로고
    • Primary and secondary responses to T cell-dependent and T cell-independent antigens
    • Liu, Y.-J., Zhang, J., Lane, P. J. L., Chan, E. Y.-T. and MacLennan, I. C. M. 1991. Primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2951
    • Liu, Y.-J.1    Zhang, J.2    Lane, P.J.L.3    Chan, E.Y.-T.4    MacLennan, I.C.M.5
  • 55
    • 0023885447 scopus 로고
    • The expression of B cell surface receptors. I. the ontogeny and distribution of the murine B cell IgE Fc receptor
    • Waldschmidt, T. J., Conrad, D. H. and Lynch, R. G. 1988. The expression of B cell surface receptors. I. The ontogeny and distribution of the murine B cell IgE Fc receptor. J. Immunol. 140:2148.
    • (1988) J. Immunol. , vol.140 , pp. 2148
    • Waldschmidt, T.J.1    Conrad, D.H.2    Lynch, R.G.3
  • 56
    • 0022494247 scopus 로고
    • Functional characterization of monoclonal auto-anti-idiotype antibodies isolated from the early B cell repertoire of BALB/c mice
    • Vakil, M. and Kearney, J. F. 1986. Functional characterization of monoclonal auto-anti-idiotype antibodies isolated from the early B cell repertoire of BALB/c mice. Eur. J. Immunol. 16:1151.
    • (1986) Eur. J. Immunol. , vol.16 , pp. 1151
    • Vakil, M.1    Kearney, J.F.2
  • 58
    • 0028064578 scopus 로고
    • Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
    • Cyster, J. G., Hartley, S. B. and Goodnow, C. C. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 371:389.
    • (1994) Nature , vol.371 , pp. 389
    • Cyster, J.G.1    Hartley, S.B.2    Goodnow, C.C.3
  • 60
    • 0025432829 scopus 로고
    • B cell development in the bone marrow
    • Osmond D. G. 1990. B cell development in the bone marrow. Semin. Immunol. 2:73.
    • (1990) Semin. Immunol. , vol.2 , pp. 73
    • Osmond, D.G.1
  • 61
    • 0026271120 scopus 로고
    • Functional relationship between T15 and J558 idiotypes in BALB/c mice
    • Vakil, M. and Kearney, J. F. 1991. Functional relationship between T15 and J558 idiotypes in BALB/c mice. Dev. Immunol. 1:213.
    • (1991) Dev. Immunol. , vol.1 , pp. 213
    • Vakil, M.1    Kearney, J.F.2
  • 62
    • 0014307334 scopus 로고
    • Competition of 19S and 7S antigen receptors in the regulation of the primary immune response
    • Henry, C. and Jerne, N. K. 1968. Competition of 19S and 7S antigen receptors in the regulation of the primary immune response. J. Exp. Med. 128:133.
    • (1968) J. Exp. Med. , vol.128 , pp. 133
    • Henry, C.1    Jerne, N.K.2
  • 64
    • 0028961264 scopus 로고
    • Protein tyrosine phosphatase 1C negatively regulates antigen receptor signalling in B lymphocytes and determines thresholds for negative selection
    • Cyster, J. G. and Goodnow, C. C. 1995. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signalling in B lymphocytes and determines thresholds for negative selection. Immunity 2.13.
    • (1995) Immunity , vol.2 , pp. 13
    • Cyster, J.G.1    Goodnow, C.C.2
  • 65
    • 0028354220 scopus 로고
    • Development of B-1 cells: Segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression
    • Arnold, L. W., Pennell, C. A., McCray, S. K. and Clarke, S. H. 1994. Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression. J. Exp. Med. 179:1585.
    • (1994) J. Exp. Med. , vol.179 , pp. 1585
    • Arnold, L.W.1    Pennell, C.A.2    McCray, S.K.3    Clarke, S.H.4
  • 66
    • 0027514683 scopus 로고
    • Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice
    • Tighe, H., Chen, P. P., Tucker, R., Kipps, T. J., Roudier, J., Jirik, F. R. and Carson, D. A. 1993. Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. J. Exp. Med. 177:109.
    • (1993) J. Exp. Med. , vol.177 , pp. 109
    • Tighe, H.1    Chen, P.P.2    Tucker, R.3    Kipps, T.J.4    Roudier, J.5    Jirik, F.R.6    Carson, D.A.7
  • 67
    • 0028945022 scopus 로고
    • Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice
    • Tighe, H., Heaphy, P., Baird, S., Weigle, W. O. and Carson, D. A. 1995. Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice. J. Exp. Med. 181:599.
    • (1995) J. Exp. Med. , vol.181 , pp. 599
    • Tighe, H.1    Heaphy, P.2    Baird, S.3    Weigle, W.O.4    Carson, D.A.5
  • 68
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen, L. A., Anhalt, G. J. and Rosen, A. 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179:1317.
    • (1994) J. Exp. Med. , vol.179 , pp. 1317
    • Casciola-Rosen, L.A.1    Anhalt, G.J.2    Rosen, A.3
  • 69
    • 0028881847 scopus 로고
    • DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
    • Casciola-Rosen, L. A., Anhalt, G. J. and Rosen, A. 1995, DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med. 182:1625.
    • (1995) J. Exp. Med. , vol.182 , pp. 1625
    • Casciola-Rosen, L.A.1    Anhalt, G.J.2    Rosen, A.3
  • 70
    • 0028206650 scopus 로고
    • Autoimmunity and apoptosis
    • Tan, E. M. 1994. Autoimmunity and apoptosis. J. Exp. Med. 179:1083.
    • (1994) J. Exp. Med. , vol.179 , pp. 1083
    • Tan, E.M.1
  • 71
    • 0030023652 scopus 로고    scopus 로고
    • Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
    • Cyster, J. G., Healey, J. I., Kishihara, K., Mak, T. W., Thomas, M. L. and Goodnow, C. C. 1996. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 381:325.
    • (1996) Nature , vol.381 , pp. 325
    • Cyster, J.G.1    Healey, J.I.2    Kishihara, K.3    Mak, T.W.4    Thomas, M.L.5    Goodnow, C.C.6
  • 72
    • 0022481677 scopus 로고
    • Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody
    • Kraal, G. and Janse, M. 1986. Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody. Immunology 58:665.
    • (1986) Immunology , vol.58 , pp. 665
    • Kraal, G.1    Janse, M.2


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