Most marginal zone B cells in rat express germline encoded Ig V(H) genes and are ligand selected

Journal of Immunology

Volumn 165, Issue 11, 2000, Pages 6156-6169

  Dammers, P M ^a   Visser, A ^a   Popa, E R ^a   Nieuwenhuis, P ^a   Kroese, F G M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN;

ANIMAL CELL; ANTIGENICITY; ARTICLE; BACTERIAL CELL WALL; CELL MIGRATION; CELL SUBPOPULATION; CHROMATIN CONDENSATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GENETIC CODE; GENETIC COMPLEMENTATION; GERM LINE; IMMUNOGLOBULIN VARIABLE REGION; LIGAND BINDING; MEMORY CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SOMATIC MUTATION; SPLEEN CELL;

EID: 0034541173     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.11.6156     Document Type: Article

References (66)

1. Cells in the marginal zone of the spleen
2. Marginal zone B cells respond to both polysaccharide antigens and protein antigens
3. Human marginal-zone B cells
4. Marginal zone B cells express CR1 and CR2 receptors
5. The expression of B cell surface receptors. III. The murine low-affinity IgE Fe receptor is not expressed on Ly 1 or 'Ly 1-like' B cells
6. IgM(high)CD21(high) lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells
7. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
8. Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells
9. B cell populations in antigen-free mice
10. The spleen of germ free animals
11. Germinal centers in germfree animals
12. - B lymphocyte lineages in the rat
13. Marginal zones: The major B cell compartment of the rat spleens
14. CD1(high) B cells: A population of mixed origin
15. The origin of marginal zone B cells in the rat
16. Immunoglobulin V(H) gene analysis in rat: Most marginal zone B cells express germline encoded V(H) genes and are ligand selected
17. Evidence for selection of a population of multi-reactive B cells into the spleric marginal zone
18. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production CD19, and Bik
19. Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zone
20. Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells
21. Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion
22. Identification of functional human splenic memory B cells by expression of CD148 and CD27
23. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
24. De novo germinal center formation
25. Germinal centres and the origin of the B-cell system. II. Germinal centres in the rabbit spleen and popliteal lymph nodes
26. Immunology of the rat
27. The rat B cell system: The anatomical localization of flow cytometry-defined B cell subpopulations
28. In situ visualisation of hematopoietic cell subsets and stromal elements in the rat and mouse bone marrow by immunostaining of frozen sections
29. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes
30. IMGT, the international ImMunoGeneTics database
31. Immunoglobulin heavy-chain joining genes in the rat: Comparison with mouse and human
32. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
33. Identification and kinetics of two recently bone marrow derived B cell populations in peripheral lymphoid tissues
34. Immunoglobulin heavy chain locus of the rat: Striking ho mology to mouse antibody genes
35. Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-,J joining
36. The CDR1 sequences of a major proportion of human germline Ig V(H) genes are inherently susceptible to amino acid replacement
37. Kinetics of B cell subpopulations in peripheral lymphoid tissues: Evidence for the presence of phenotypically distinct short-lived and long-lived B cell subsets
38. Preferential usage of J(H)2 in D-J joinings with D(Q52) is determined by the primary DNA sequence and is largely dependent on recombination signal sequences
39. Joining of immunoglobulin heavy chain gene segments: Implications from a chromosome with evidence of three D-J(H) fusions
40. Mechanistic constrains on diversity in human V(D)J recombination
41. Somatic hypermutation and affinity maturation
42. The species-specific structure of microanatomical compartments in the human spleen: Strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone
43. Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3
44. Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors
45. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimetic human immunoglobulin heavy and light chain V segments
46. Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection
47. Effect of amino acid substitutions in the heavy chain CDR3 of an autoantibody on its reactivity
48. + IgM autoantibodies in lupus prone motheaten mice
49. B-1a, B-1b and B-2B cells display unique V(H)DJ(H) repertoires formed at different stages of ontogeny and under different selection pressures
50. Developmental origins, specificities and immunoglobulin gene biases of murine Ly-1 B cells
51. B-1 cells and their reactivity with the murine intestinal microflora
52. Developmental regulation of the human antibody repertoire
53. Clonal selection and learuing in the antibody system
54. Positive selection of natural autoreactive B cells
55. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
56. Antigen receptor signaling gives lymphocytes a long life
57. B-cell receptor regulation of peripheral B cells
58. Signaling threshold and interclonal competition in preimmune B-cell selection
59. Positive versus negative signaling by lymphocyte antigen receptors
60. Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice
61. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae
62. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
63. Control of early vital and bacterial distribution and disease by natural antibodies