Absence of P-selectin delays fatty streak formation in mice

Journal of Clinical Investigation

Volumn 99, Issue 5, 1997, Pages 1037-1043

  Johnson, Robert C ^a,e   Chapman, Susan M ^a   Dong, Zhao Ming ^a   Ordovas, Jose M ^b   Mayadas, Tanya N ^a   Herz, Joachim ^c   Hynes, Richard O ^d   Schaefer, Ernst J ^b   Wagner, Denisa D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TUFTS UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

animal model for atherosclerosis; cell adhesion; endothelium; hypercholesterolemia; macrophage

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; PADGEM PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL ADHESION; CROSS BREEDING; FAMILIAL HYPERCHOLESTEROLEMIA; LEUKOCYTE; MESENTERY BLOOD VESSEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; TISSUE SECTION;

EID: 0030958112     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119231     Document Type: Article

References (52)

1. Gerrity, R.G. 1981. The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am. J. Pathol. 103:181-190.
2. Ross, R. 1986. The pathogenesis of atherosclerosis: an update. N. Engl. J. Med. 314:488-500.
3. Faggiotto, A., R. Ross, and L. Harker. 1984. Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation. Arteriosclerosis. 4:323-340.
4. Aviram, M. 1995. LDL-platelet interaction under oxidative stress induces macrophage foam cell formation. Thromb. Haemostasis. 74:560-564.
5. McEver, R.P., K.L. Moore, and R.D. Cummings. 1995. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J. Biol. Chem. 270: 11025-11028.
6. Tedder, T.F. 1995. The selectins: Vascular adhesion molecules. FASEB J. 9:866-873.
7. Bonfanti, R., B.C. Furie, B. Furie, and D.D. Wagner. 1989. PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood. 73:1109-1112.
8. McEver, R.P., J.H. Beckstead, K.L. Moore, L. Marshall-Carlson, and D.F. Bainton. 1989. GMP-140, a platelet alpha granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J. Clin. Invest. 84:92-99.
9. Stenberg, P.E., R.P. McEver, M.A. Shuman, Y.V. Jacques, and D.F. Bainton. 1985. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J. Cell Biol. 101:880-886.
10. Berman, C.L., E.L. Yeo, J.D. Wencel-Drake, B.C. Furie, M.H. Ginsberg, and B. Furie. 1986. A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein. J. Clin. Invest. 78:130-137.
11. Wagner, D.D. 1993. The Weibel-Palade Body: the storage granule for von Willebrand factor and P-selectin. Throm. Haemostasis. 70:105-110.
12. Springer, T.A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell. 76:301-314.
13. Sanders, W.E., R.W. Wilson, C.M. Ballantyne, and A.L. Beaudet. 1992. Molecular cloning and analysis of in vivo expression of murine P-selectin. Blood. 80:795-800.
14. Weller, A., S. Isenmann, and D. Vestweber. 1992. Cloning of the mouse endothelial selectins. Expression of both E-and P-selectin is inducible by tumor necrosis factor alpha. J. Biol. Chem. 267:15176-15183.
15. Mayadas, T.N., R.C. Johnson, H. Rayburn, R.O. Hynes, and D.D. Wagner. 1993. Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell. 74:541-554.
16. Johnson, R.C., T.N. Mayadas, P.S. Frenette, R.E. Mebius, M. Subramaniam, A. Lacasce, R.O. Hynes, and D.D. Wagner. 1995. Blood cell dynamics in P-selectin-deficient mice. Blood. 86:1106-1114.
17. Subramaniam, M., S. Saffaripour, S.R. Watson, T.N. Mayadas, R.O. Hynes, and D.D. Wagner. 1995. Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. J. Exp. Med. 181: 2277-2282.
18. Shih, D.M., C. Welch, and A.J. Lusis. 1995. New insights into atherosclerosis from studies with mouse models. Mol. Med. Today. 1:364-372.
19. Frenette, P.S., R.C. Johnson, R.O. Hynes, and D.D. Wagner. 1995. Platelets roll on stimulated endothelium in vivo: An interaction mediated by endothelial P-selectin. Proc. Natl. Acad. Sci. USA. 92:7450-7454.
20. Ley, K., D.C. Bullard, M.L. Arbones, R. Bosse, D. Vestweber, T.F. Tedder, and A.L. Beaudet. 1995. Sequential contribution of L-and P-selectin to leukocyte rolling in vivo. J. Exp. Med. 181:669-675.
21. Ishibashi, S., M.S. Brown, J.L. Goldstein, R.D. Gerard, R.E. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92:883-893.
22. Ishibashi, S., J.L. Goldstein, M.S. Brown, J. Herz, and D.K. Burns. 1994. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93:1885-1893.
23. Nishina, P.M., J. Verstuyft, and B. Paigen. 1990. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J. Lipid Res. 31:859-869.
24. Shireman, R.B., and J. Duriex. 1993. Microplate methods for the determination of serum cholesterol, high density lipoprotein cholesterol, tryglyceride and apoliporproteins. Lipids. 28:151-155.
25. Chapman, M.J., S. Goldstein, D. Lagrange, and P.M. Laplaud. 1981. A density gradient ultracentrifugal procedure for the isolation of the major lipoprotein classes from human serum. J. Lipid Res. 22:339-358.
26. Paigen, B., A. Morrow, P.A. Holmes, D. Mitchell, and R.A. William. 1987. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 68:231-240.
27. Kunjathoor, V., D.L. Wilson, and R.C. LeBoeuf. 1996. Increased atherosclerosis in streptozotocin-induced diabetic mice. J. Clin. Invest. 97:1767-1773.
28. Breslow, J.L. 1996. Mouse models of atherosclerosis. Science (Wash. DC). 272:685-688.
29. Plump, A.S., J.D. Smith, T. Hayek, K. Aalto-Setala, A. Walsh, J.G. Verstuyft, E.W. Rubin, and J.L. Breslow. 1992. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 71:343-353.
30. Piedrahita, J.A., S.H. Zhang, R. Hagaman, P.M. Oliver, and N. Maeda. 1992. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. USA. 89:4471-4475.
31. Nakashima, Y., A.S. Plump, E.W. Raines, J.L. Breslow, and R. Ross. 1994. Apo E-deficient mice develop lesion of all all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. 14:133-140.
32. Tangirala, R.K., E.M. Rubin, and W. Palinski. 1995. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J. Lipid Res. 36:2320-2328.
33. Wagner, D.D., J.B. Olmsted, and V.J. Marder. 1982. Immunolocalization of von Willebrand protein in weibel-palade bodies of human endothelial cells. J. Cell Biol. 95:355-360.
34. Trillo, A.A., and R.W. Prichard. 1979. Early endothelial changes in experimental primate atherosclerosis. Lab. Invest. 41:294-301.
35. Johnson-Tidey, R.R., J.L. McGregor, P.R. Taylor, and R.N. Poston. 1994. Increase in the adhesion molecule P-selectin in the endothelium overlying atherosclerotic plaques: coexpression with intercellular adhesion molecule-1. Am. J. Pathol. 144:952-961.
36. Cybulsky, M.I., and M.A. Gibrone, Jr. 1991. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science (Wash. DC). 251:788-791.
37. Poston, R.N., D.O. Haskard, J.R. Coucher, N.P. Gall, and R.R. Johnson-Tidey. 1992. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am. J. Path. 140:665-673.
38. O'Brien, K.D., M.D. Allen, T.O. McDonald, A. Chait, J.M. Harlan, D. Fishbein, J. McCarty, M. Ferguson, K. Hudkins, C.D. Benjamin, et al. 1993. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. J. Clin. Invest. 92:945-951.
39. Gebuhrer, V., J.F. Murphy, J. Bordet, M. Reck, and J.L. McGregor. 1995. Oxidized low-denisty lipoprotein induces the expression of P-selectin (GMP 140/PADGEM/CD62) on human endothelial cells. J. Biochem. 306:293-298.
40. Mehta, A., B. Yang, S. Khan, J.B. Hendricks, C. Stephen, and J.L. Mehta. 1995. Oxidized low-denisty lipoproteins facilitate leukocyte adhesion to aortic intima without affecting endothelium-dependent relaxation role of P-selectin. Thromb. Vasc. Biol. 15:2076-2083.
41. Lehr, H., A.M. Olofsson, T.E. Carew, P. Vajkoczy, U.H. von Andrian. C. Hubner, M.C. Berndt, D. Steinberg, K. Messmer, and K.E. Arfors. 1994. P-selectin mediates the interaction of circulating leukocytes with platelets and microvascular endothelium in response to oxidized lipoprotein in vivo. Lab. Invest. 71:380-386.
42. Caulin-Glaser, T., C.A. Watson, R. Pardi, and J.R. Bender. 1996. Effects of 17β-estradiol on cytokine-induced endothelial cell adhesion molecule expression. J. Clin. Invest. 98:36-42.
43. Gossland, I.F., V. Wynn, D. Crook, and N.E. Miller. 1987. Sex, plasma lipoproteins and atherosclerosis:prevailing assumptions and outstanding questions. Am. Heart J. 114:1467-1503.
44. Smith, J.D., E. Trogan, M. Ginsberg, C. Grigaux, J. Tian, and M. Miyata. 1995. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc. Natl. Acad. Sci. USA. 92:8264-8268.
45. 44a. Subramaniam, M., S. Saffaripour, L. Van De Water, P.S. Frenette, T.N. Mayadas, R.O. Haynes, and D.D. Wagner. 1997. Role of endothelial selectins in wound repair. Am. J. Pathol. In press.
46. Palabrica, T., R. Lobb, B.C. Furie, M. Aronovitz, C. Benjamin, Y. Hsu, S.A. Sajer, and B. Furie. 1992. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature (Lond.). 359:848-851.
47. Larsen, E., A. Celi, G.E. Gilbert, B.C. Furie, J.K. Erban, R. Bonfanti, and D.D. Wagner. 1989. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell. 59:305-312.
48. Hamburger, S.A., and R.P. McEver. 1990. GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood. 75:550-554.
49. Sevitt, S. 1986. Platelets and foam cells in the evolution of atherosclerosis. Histological and immunohistological studies of human lesions. Atherosclerosis. 61:107-115.
50. Curtiss, L.K., A.S. Black, Y. Takagi, and E.F. Plow. 1987. New mechanism for foam cell generation in atherosclerotic lesions. J. Clin. Invest. 80:367-373.
51. Maor, I., G.J. Brook, and M. Aviram. 1991. Platelet secreted lipoprotein-like particle is taken up by the macrophage scavenger receptor and enhances cellular cholesterol accumulation. Atherosclerosis. 88:163-174.
52. Weyrich, A.S., T.M. McIntyre, R.P. McEver, S.M. Prescott, and G.A. Zimmerman. 1995. Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor alpha secretion. J. Clin. Invest. 95:2297-2303.