Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide

European Journal of Pharmacology

Volumn 330, Issue 2-3, 1997, Pages 221-229

  Taniguchi, Yasuaki ^a   Yokoyama, Kazuyuki ^a   Inui, Keiichiro ^a   Deguchi, Yoshiki ^a   Furukawa, Koji ^a   Noda, Kanji ^a  

^a HISAMITSU PHARMACEUTICAL CO INC   (Japan)

Author keywords

Antipyretic action; Cyclooxygenase 2; Hypothalamus; Nimesulide; RT PCR (reverse transcription and polymerase chain reaction); Yeast induced hyperthermia

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IBUPROFEN; INDOMETACIN; MESSENGER RNA; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2;

ANIMAL MODEL; ANIMAL TISSUE; ANTIPYRETIC ACTIVITY; ARTICLE; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; FEVER; HYPOTHALAMUS; IN VITRO STUDY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BODY TEMPERATURE; BRAIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; FEMALE; FEVER; HYPOTHALAMUS; ISOENZYMES; MALE; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; RNA, MESSENGER; SULFONAMIDES;

EID: 0030852821     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00183-0     Document Type: Article

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