Methods for linkage analysis of quantitative trait loci in humans

Theoretical Population Biology

Volumn 60, Issue 3, 2001, Pages 167-180

  Feingold, Eleanor ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETICS;

BAYES THEOREM; CHROMOSOME MAP; GENE LINKAGE DISEQUILIBRIUM; HUMAN; METHODOLOGY; QUANTITATIVE TRAIT; REVIEW; STATISTICAL MODEL;

BAYES THEOREM; CHROMOSOME MAPPING; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, STATISTICAL; QUANTITATIVE TRAIT, HERITABLE;

EID: 0035528922     PISSN: 00405809     EISSN: None     Source Type: Journal    
DOI: 10.1006/tpbi.2001.1545     Document Type: Article

References (76)

1. Maximum-likelihood-binomial method for genetic model-free linkage analysis of quantitative traits in sibships
2. Linkage analysis of quantitative trait loci: Sib pairs or sibships?
3. Extreme selection strategies in gene mapping studies of oligogenic quantitative traits do not always increase power
4. Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure
5. Testing the robustness of the new Haseman-Elston quantitative-trait loci-mapping procedure
6. Bivariate quantitative trait linkage analysis: Pleiotropy versus coincident linkages
7. Multipoint quantitative-trait linkage analysis in general pedigrees
8. Robust methods for the detection of genetic linkage for quantitative data from pedigrees
9. A more powerful robust sib-pair test of linkage for quantitative traits
10. Robust variance-components approach for assessing genetic linkage in pedigrees
11. Robust inference for variance components models in families ascertained through probands: II. Analysis of spirometric measures
12. Power and robustness of sib-pair linkage tests and extension to larger sibships
13. A comparison of sib-pair linkage tests for disease susceptibility loci
14. Robust LOD scores for variance component-based linkage analysis
15. The power of interval mapping of quantitative trait loci, using selected sib pairs
16. Linkage analysis of quantitative traits: Increased power by using selected samples
17. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
18. Comparison of nonparametric statistics for detection of linkage in nuclear families: Single marker evaluation
19. Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees
20. Ascertainment issues in variance components models
21. A simulation study of the effects of assignment of prior identity-by-descent probabilities to unselected sib pairs, in covariance-structure modeling of a quantitative-trait locus
22. The probability that related individuals share some section of the genome identical by descent
23. How sib pairs reveal linkage
24. A score test for the linkage analysis of qualitative and quantitative traits based on identity by descent data on sib-pairs
25. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7
26. Locating human quantitative trait loci: Guidelines for the selection of sibling pairs for genotyping
27. Haseman and Elston revisited
28. Markov processes for modeling and analyzing a new genetic mapping method
29. Gaussian models for linkage analysis using complete high resolution maps of identity-by-descent
30. A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia
31. Composite statistics for QTL mapping with moderately discordant sibling pairs
32. Weighting improves the "new Haseman-Elston" method
33. Multiple regression analysis of sib-pair data on reading to detect quantitative trait loci
34. Multipoint analysis of human quantitative genetic variation
35. Power and robustness of a score test for linkage analysis of quantitative traits using identity by descent data on sib pairs
36. Reversible jump Markov chain Monte Carlo computation and Bayesian model determination
37. Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of QTLs
38. The investigation of linkage between a quantitative trait and a marker locus
39. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models
40. An empirical test of the significance of an observed quantitative trait locus effect that preserves additive genetic variation
41. Evaluation of a restricted likelihood ratio test for mapping quantitative trait loci with extreme discordant sib pairs
42. Complete multipoint sib-pair analysis of qualitative and quantitative traits
43. The "possible triangle" test for extreme discordant sib pairs
44. Performance of Markov chain-Monte Carlo approaches for mapping genes in oligogenic models with an unknown number of loci
45. A weighted test using both extreme discordant and concordant sib pairs for detecting linkage
46. A unified sampling approach for multipoint analysis of qualitative and quantitative traits in sib pairs
47. Power of variance component linkage analysis to detect epistasis
48. Analysis of family resemblance III. Complex segregation analysis of quantitative traits
49. Linkage between quantitative trait and marker loci: Methods using all relative pairs
50. Haseman and Elston revisited: The effects of ascertainment and residual familial correlations on power to detect linkage
51. Extreme discordant sib pairs for mapping quantitative trait loci in humans
52. Mapping quantitative trait loci with extreme discordant sib pairs: Sampling considerations
53. A Bayesian approach to detect quantitative trait loci using Markov chain Monte Carlo
54. Variance components QTL linkage analysis of selected and non-normal samples: Conditioning on trait values
55. Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs
56. Adding further power to the Haseman and Elston method for detecting linkage
57. Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker-sharing statistics
58. Multipoint estimation of IBD probabilities at arbitrary positions among marker loci on general pedigrees
59. Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans
60. Mapping quantitative trait loci in oligogenic models
61. Trade-off between sibship size and sampling scheme for detecting quantitative trait loci
62. Effects of genotype-by-sex interaction on quantitative trait linkage analysis
63. Genetic linkage analysis using lognormal variance components
64. A statistically robust variance-components approach for quantitative trait linkage analysis
65. Transformation of sib-pair values for the Haseman-Elston method
66. A class of tests for linkage using affected pedigree members
67. Analysis of complex genetic traits: Applications to asthma and simulated data
68. The phenotypic difference discards sib-pair QTL linkage information
69. An extreme-sib-pair genome scan for genes regulating blood pressure
70. A unified Haseman-Elston method for testing linkage with quantitative traits
71. Bayesian mapping of quantitative trait loci under the identity-by-descent-based variance component model
72. Introduction of the IBD information into the weighted pairwise correlation method for linkage analysis