Evaluation of a restricted likelihood ratio test for mapping quantitative trait loci with extreme discordant sib pairs

Annals of Human Genetics

Volumn 62, Issue 1, 1998, Pages 75-87

  Knapp, M ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; DOMINANT GENE; ERROR; GENE LOCUS; GENE MAPPING; GENETIC MODEL; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RECESSIVE GENE; SAMPLE; SIBLING;

ALLELES; CHROMOSOME MAPPING; GENES, DOMINANT; GENES, RECESSIVE; HUMANS; LIKELIHOOD FUNCTIONS; MATHEMATICS; MODELS, GENETIC; QUANTITATIVE TRAIT, HERITABLE;

EID: 0031847035     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0003480098006617     Document Type: Article

References (15)

1. BLACKWELDER, W. C. & ELSTON, R. C. (1982). Power and robustness of sib-pair linkage tests and extensions to larger sibships. Commun. Stat. Theory Methods 11, 449-484.
2. BLACKWELDER, W. C. & ELSTON, R. C. (1985). A comparison of sib-pair linkage tests for disease susceptibility loci. Genet. Epidemiol. 2, 85-97.
3. CAREY, G. & WILLIAMSON, J. (1991). Linkage analysis of quantitative traits: increased power by using selected samples. Am. J. Hum. Genet. 49, 786-796.
4. DEMPSTER, A. P., LAIRD, N. M. & RIBIN, D. B. (1977). Maximum likelihood from incomplete data via the EM algorithm. J. R. Stat. Soc. Ser. B 39, 1-22.
5. FARAWAY, J. J. (1993). Improved sib-pair linkage test for disease susceptibility loci. Genet. Epidemiol. 10, 220-233.
6. HASEMAN, J. K. & ELSTON, R. C. (1972). The investigation of linkage between a quantitative trait and a marker locus. Behav. Genet. 2, 3-19.
7. HOLMANS, P. (1993). Asymptotic properties of affected-sib-pair linkage analysis. Am. J. Hum. Genet. 52, 362-374.
8. KNAPP, M. (1991). A powerful test of sib-pair linkage for disease susceptibility. Genet. Epidemiol. 8, 141-142.
9. KNAPP, M., SEUCHTER, S. A. & BAUR, M. P. (1994). Two-locus disease models with two marker loci: the power of affected-sib-pair-tests. Am. J. Hum. Genet. 55, 1030-1041.
10. RISCH, N. (1990). Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am. J. Hum. Genet. 46, 242-253.
11. RISCH, X. & ZHANG, H. (1995). Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268, 1584-1589.
12. RISCH, N. & ZHANG, H. (1996). Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am. J. Hum. Genet. 58, 836-843.
13. SCHAID, D. J. & NICK, T. G. (1990). Sib-pair linkage tests for disease susceptibility loci: common tests vs. the asymptotically most powerful test. Genet. Epidemiol. 7, 359-370.
14. SELF, S. G. & LIANG, K. Y. (1987). Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. J. Am. Stat. Assoc. 82, 605-610.
15. SUAREZ, B. K., RICE, J. & REICH, T. (1978). The generalized sib pair IBD distribution: its use in the detection of linkage. Ann. Hum. Genet. 42, 87-94.