Extreme selection strategies in gene mapping studies of oligogenic quantitative traits do not always increase power

Human Heredity

Volumn 48, Issue 2, 1998, Pages 97-107

  Allison, David B ^a,f   Heo, Moonseong ^a   Schork, Nicholas J ^b,c,d,e   Wong, Su Ling ^a   Elston, Robert C ^b  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d JACKSON LABORATORY   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

^f ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

Association studies; Extreme sampling; Linkage; Oligogenic traits; Power; Quantitative trait loci; Quantitative traits; Selective sampling

Indexed keywords

ARTICLE; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOTYPE; MATHEMATICAL ANALYSIS; PHENOTYPE; QUANTITATIVE TRAIT; SAMPLING; SIBLING; STATISTICAL ANALYSIS;

CHROMOSOME MAPPING; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC; QUANTITATIVE TRAIT, HERITABLE;

EID: 0031909410     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022788     Document Type: Article

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