Extreme selection strategies in gene mapping studies of oligogenic quantitative traits do not always increase power

Human Heredity

Volumn 48, Issue 2, 1998, Pages 97-107

  Allison, David B ^a,f   Heo, Moonseong ^a   Schork, Nicholas J ^b,c,d,e   Wong, Su Ling ^a   Elston, Robert C ^b  

^a The New York Presbyterian Hospital   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d JACKSON LABORATORY   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

^f ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

Association studies; Extreme sampling; Linkage; Oligogenic traits; Power; Quantitative trait loci; Quantitative traits; Selective sampling

Indexed keywords

ARTICLE; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOTYPE; MATHEMATICAL ANALYSIS; PHENOTYPE; QUANTITATIVE TRAIT; SAMPLING; SIBLING; STATISTICAL ANALYSIS;

CHROMOSOME MAPPING; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC; QUANTITATIVE TRAIT, HERITABLE;

EID: 0031909410     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022788     Document Type: Article

References (21)

1. Lander ES, Schork NJ: Genetic dissection of complex traits. Science 1994;265:2037-2048
2. Amos CI, Elston RC: Robust methods for the detection of genetic linkage for quantitative data from pedigrees. Genet Epidemiol 1989;6: 349-360.
3. Blackwelder WC, Elston RC: Power and robustness of sib-pair linkage tests and extension to larger sib-ships. Commun Stat Theory Methods 1982;11:449-484.
4. Blackwelder WC, Elston RC: A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol 1985;2:85-97.
5. Cardon LR, Fulker DW: The power of interval mapping of quantitative trait loci, using selected sib pairs. Am J Hum Genet 1994,55.825-833.
6. Carey G, Williamson JA: Linkage analysis of quantitative traits: Increased power by using selected samples. Am J Hum Genet 1991;49: 786-796.
7. Eaves L, Meyer J: Locating human quantitative trait loci: Guidelines for the selection of sibling pairs for genotyping. Behav Genet 1994;24: 443-455.
8. Gu C, Todorov A, Rao DC: Combining extremely concordant sib-pairs with extremely discordant sib-pairs provides a cost effective way to linkage analysis of quantitative trait loci. Geaet Epidemiol 1996;13:313-533.
9. Risch N, Zhang H: Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 1995;268:1584-1589.
10. Risch N, Zhang H: Mapping quantitative trait loci with extreme discordant sib pairs: Sampling considerations. Am J Hum Genet 1996;58: 836-843.
11. Clement K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froeget P, Strosberg AD: Genetic variation in the beta 3-adrenergic receptor and increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995;333:352-354.
12. Lander ES, Botstein D: Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 1989;121:185-199.
13. Allison DB: Transmission disequilibrium tests for quantitative traits. Am J Hum Genet 1997;60:676-690.
14. Abrahams NM, Alf EF: Relative costs and statistical power in the extreme groups approach. Psychometrika 1978;4:11-17.
15. Alf EF, Abrahams NM: The use of extreme groups in assessing relationships. Psychometrika 1975;40:563-572.
16. Feldt LS: The use of extreme groups to test for the presence of a relationship. Psychometrika 1961;26:307-316.
17. Korol AB, Ronin YI, Kizhner VM: Linkage between quantitative trait loci and marker loci: Resolution power of three statistical approaches in single marker analysis. Biometrics 1996;52:426-441.
18. Gorman BS, Primavera L, Allison DB: A simple computer program for power and sample size estimation. Ed Psych Meas 1995;55:773-776.
19. West DB, Goudey-Lefevre J, York B, Truett GE: Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest 1994;94:1410-1416.
20. Allison DB, Schork NJ: Selected methodological issues in meiotic mapping of obesity genes in humans: Issues of power and efficiency. Behav Genet 1997;27:401-421.
21. Schork NJ, Boehnke M, Terwilliger JD, Ott J: Two-trait-locus linkage analysis: A powerful strategy for mapping complex genetic traits. Am J Hum Genet 1994;55:1127-1136.