Maximum-Likelihood-Binomial method for genetic model-free-linkage analysis of quantitative traits in sibships

Genetic Epidemiology

Volumn 17, Issue 2, 1999, Pages 102-117

  Alcaïs, Alexandre ^a   Abel, Laurent ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Binomial distributions; Likelihood; Linkage analysis; Model free; Quantitative trait locus

Indexed keywords

ALLELE; ARTICLE; GENE MAPPING; GENETIC ANALYSIS; GENETIC EPIDEMIOLOGY; GENETIC LINKAGE; HUMAN; MAXIMUM LIKELIHOOD METHOD; QUANTITATIVE TRAIT; SIBLING; SIMULATION; STATISTICAL MODEL;

ALLELES; BINOMIAL DISTRIBUTION; CHROMOSOME MAPPING; GENOTYPE; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); MODELS, GENETIC; MODELS, STATISTICAL; NUCLEAR FAMILY; PHENOTYPE;

GENETTA;

EID: 0033052468     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1999)17:2<102::AID-GEPI2>3.0.CO;2-6     Document Type: Article

References (17)

1. Abel L, Alcaïs A, Mallet A. 1998. Comparison of four sib-pair linkage methods for analyzing sibships with more than two affecteds: interest of the binomial maximum likelihood approach. Genet Epidemiol 15:371-390.
2. Abel L, Müller-Myhsok B. 1998. Robustness and power of the Maximum-Likelihood-Binomial and Maximum-Likelihood-Score methods, in multipoint linkage analysis of affected-sibship data. Am J Hum Genet 63:638-647.
3. Amos CI, Krushkal J, Thiel TJ, Young A, Zhu DK, Boerwinkle E, de Andrade M. 1997. Comparison of model-free linkage mapping strategies for the study of a complex trait. Genet Epidemiol 14:743-748.
4. Blackwelder WC, Elston RC. 1982. Power and robustness of sib-pair linkage tests and extension to larger sibships. Commun Stat Theory Methods 11:449-484.
5. Blangero J, Almasy L. 1997. Multipoint Oligogenic linkage analysis of Quantitative traits. Genet Epidemiol 14:959-964.
6. Fulker DW, Cherny SS. 1996. An improved multipoint sib-pair analysis of quantitative trait. Behav Genet 26:527-532.
7. Goldgar DE. 1990. Multipoint analysis of human quantitative genetic variation. Am J Hum Genet 47:957-967.
8. Gu C, Todorov A, Rao DC. 1996. Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci. Genet Epidemiol 13:513-533.
9. Haseman JK, Elston RC. 1972. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 26:527-532.
10. Knapp M, Seuchter SA, Bauer MP. 1994. Linkage analysis in nuclear families. 2: Relationship between affected sib-pair tests and lod-score analysis. Hum Hered 44:44-51.
11. Kruglyak L, Lander ES. 1995. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454.
12. Majumder PP, Pal N. 1987. Nonrandom segregation: uniformly most powerful test and related considerations. Genet Epidemiol 4:277-287.
13. Morton NE, MacLean CJ. 1974. Analysis of familial resemblance. III. Complex segregation analysis of quantitative traits. Am J Hum Genet 26:489-503.
14. Ott J. 1992. Analysis of human genetic linkage. Baltimore: The John Hopkins University Press.
15. Risch N, Zhang H. 1995. Extreme discordant sib-pairs for mapping quantitative trait loci in humans. Science 268:1584-1589.
16. S.A.G.E. 1994. Statistical Analysis for Genetic Epidemiology. Computer program package available from the Department of Epidemiology and Biostatistics. Cleveland: Case Western Reserve University.
17. Speer MC, Terwilliger JD, Ott J. 1995. Data simulation for GAW9 Problems 1 and 2. Genet Epidemiol 12:561-564.