Downstream of Otx2, or how to get a head

Trends in Genetics

Volumn 17, Issue 11, 2001, Pages 633-636

  Boncinelli, Edoardo ^a   Morgan, Richard ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; CALPONIN; CELL ADHESION MOLECULE; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OTX2; TROPOMYOSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BRAIN DEVELOPMENT; GENE EXPRESSION; GENE TARGETING; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

ANIMALS; BODY PATTERNING; BRAIN; CIRCADIAN RHYTHM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; HUMANS; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; OTX TRANSCRIPTION FACTORS; TRANS-ACTIVATORS;

EID: 0035500601     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(01)02418-0     Document Type: Review

References (31)

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3. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
4. The orthodenticle gene encodes a novel homeodomain protein involved in the development of the Drosophila nervous system and ocellar visual structures
5. The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development
6. -/- mutants due to a defective anterior neuroectoderm specification during gastrulation
7. Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo
8. Axis development and early asymmetry in mammals
9. Early embryonic development of Xenopus laevis
10. The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions
11. Neural plate patterning: Upstream and downstream of the isthmic organizer
12. Otx and Emx homeobox genes in brain development
13. Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain
14. -/- early gastrulating mouse embryos
15. Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene
16. A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
17. Binding properties of the human homeodomain protein OTX2 to a DNA target sequence
18. The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter
19. Efficient hormone-inducible protein function in Xenopus laevis
20. Regulation of protein activities by fusion to steroid binding domains
21. Calponin modulates the exclusion of Otx-expressing cells from convergence extension movements
22. Inhibition of the relative movement of actin and myosin by caldesmon and calponin
23. The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system
24. Tenascin-C inhibits beta1 integrin dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism
25. Identification of otx2 target genes and restrictions in ectodermal competence during Xenopus cement gland formation
26. A conserved 30 base pair element in the Wnt-5a promoter is sufficient both to drive its early embryonic expression and to mediate its repression by otx2
27. Molecular bases for circadian clocks
28. The circadian gene Clock is restricted to the anterior neural plate early in development and is regulated by the neural inducer noggin and the transcription factor Otx2
29. Abnormal behavior and neurotransmissions of tenascin gene knockout mouse
30. Polysialylated neural cell adhesion molecule modulates photic signaling in the mouse suprachiasmatic nucleus
31. The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins