Otx and Emx homeobox genes in brain development

International Journal of Developmental Biology

Volumn 44, Issue 6, 2000, Pages 663-668

  Cecchi, C ^a   Mallamaci, A ^a   Boncinelli, E ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Cerebral cortex formation; Emx; Mouse forebrain development; Otx

Indexed keywords

GENE PRODUCT; PROTEIN EMX; PROTEIN EMX2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OTX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN REGION; CELL MIGRATION; CELL PROLIFERATION; CYTOARCHITECTURE; EMBRYO; FOREBRAIN; GENE EXPRESSION; HOMEOBOX; KNOCKOUT MOUSE; MESENCEPHALON; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

ANIMALS; BRAIN; CELL MOVEMENT; CEREBRAL CORTEX; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; NEURONS; OTX TRANSCRIPTION FACTORS; TIME FACTORS; TISSUE DISTRIBUTION; TRANSCRIPTION FACTORS;

EID: 0033759967     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Genetic control of brain morphogenesis through Otx gene dosage requirement
2. Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development
3. Forebrain and midbrain regions are deleted in Otx2(-/-) mutants due to a defective anterior neuroectoderm specification during gastrulation
4. Epilepsy and brain abnormalities in mice lacking the Otx1 gene
5. The subplate, a transient neocortical structure: Its role in the development of connection between thalamus and cortex
6. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
7. Determination events in the nervous system of the vertebrate embryo
8. MR imaging of schizencephaly
9. Early CNS development: Distal-less related genes and forebrain development
10. Otx and Emx homeobox genes in brain development
11. Emx and Otx genes in the developing mouse brain
12. Homeobox genes in vertebrate gastrulation
13. EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons
14. The caudal limit of Otx2 expression positions the isthmic organizer
15. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
16. A number of schizencephalic patients including 2 brothers are heterozygous for germline mutations in the homeobox gene EMX2
17. From fly head to mammalian forebrain: The story of otd and Otx
18. Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum
19. Schizencephaly: Clinical findings
20. Birthdate and cell marker analysis of scrambler: A novel mutation affecting cortical development with a reeler-like phenotype
21. Emx1 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex
22. The status of the neural segment
23. The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons
24. OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area
25. EMX2 protein in the developing mouse brain and olfactory area
26. The lack of Emx2 causes absence of Cajal-Retzius cells and reeler-like defects of neuronal migration in the developing cerebral cortex
27. Mouse Otx2 functions in the formation and patterning of rostral head
28. Strategies for the generation of neuronal diversity in the developing central nervous system
29. A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
30. Defects of urogenital development in mice lacking Emx2
31. Calponin modulates the exclusion of Otx-expressing cells from convergent extension movements
32. A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
33. Specification of neocortical areas and thalamocortical connections
34. The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons
35. The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions
36. Dentate gyrus formation requires Emx2
37. Nested expression domains of four homeobox genes in the developing rostral brain
38. Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex
39. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
40. Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration
41. Emx1 and Emx2 functions in development of dorsal telencephalon