Staining of celiac disease-relevant T cells by peptide-DQ2 multimers

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 4861-4868

  Quarsten, H ^a   McAdam, S N ^a   Jensen, T ^a   Arentz Hansen, H ^a   Molberg, O ^a   Lundin, K E A ^a   Sollid, L M ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTEN; HLA DQ ANTIGEN; LEUCINE ZIPPER PROTEIN; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CELIAC DISEASE; CELL CLONE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGENETICS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; MOLECULAR RECOGNITION; PATHOGENESIS; PRIORITY JOURNAL; SMALL INTESTINE MUCOSA; T LYMPHOCYTE;

EID: 0035500444     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.4861     Document Type: Article

References (38)

1. Phenotypic analysis of antigen-specific T lymphocytes
2. HLA-peptide tetrameric complexes
3. A new look at T cells
4. Detection of antigen specific T cells with multivalent soluble class II MHC covalent peptide complexes
5. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen
6. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands
7. Negative selection of T cells occurs throughout thymic development
8. g7 tetramers
9. u mice using peptide-MHC multimers
10. + T cells proliferating in response to influenza A antigen
11. Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis
12. Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers
13. HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: Direct detection of immunodominant antigen-responsive cells
14. Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response
15. + T cells by HLA-DRI oligomers is dependent on the T cell activation state
16. Invited anniversary review: Hla associated diseases
17. Molecular basis of celiac disease
18. Identification of a gliadin T-cell epitope in coeliac disease: General importance of gliadin deamidation for intestinal T-cell recognition
19. Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin
20. Glutenin is involved in the gluten-driven mucosal T cell response
21. The intestinal T cell response to α-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
22. Gliadin-specific HLADQ(α1*0501,β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients
23. T cells from the small intestinal mucosa of a DR4,DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8
24. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
25. Identification of tissue transglutaminase as the autoantigen of celiac disease
26. Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: A 13 residue consensus peptide specifies biotinylation in Escherichia coll
27. Characterization of an HLA-DQ2-specific monoclonal antibody: Influence of amino acid substitutions in DQβ1*0202
28. Expression of recombinant HLA-DR2 molecules: Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR αβ heterodimers
29. Production of soluble MHC class II proteins with covalently bound single peptides
30. Expression and characterization of recombinant soluble peptide: I-A complexes associated with murine experimental autoimmune diseases
31. Peptide binding characteristics of the coeliac disease-associated DQ(α1*0501, β1*0201) molecule
32. The peptide binding motif of the disease associated HLA-DQ (α1*0501, β1*0201) molecule
33. Identification of a putative motif for binding of peptides to HLA-DQ2
34. Exceptional stability of the HLA-DQA1*0102/DQB1*0602 αβ protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus
35. The crystal structure of a T cell receptor in complex with peptide and MHC class II
36. Structure of a covalently stabilized complex of a human αβ T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DRI
37. The gluten specific T cell response in pediatric celiac disease patients
38. + T cell responses in neonatal mice: Susceptibility to polyoma virus-induced tumors is associated with lack of cytotoxic function by viral antigen-specific T cells