Immunity proteins: Enzyme inhibitors that avoid the active site

Trends in Biochemical Sciences

Volumn 26, Issue 10, 2001, Pages 624-631

  Kleanthous, Colin ^a   Walker, Daniel ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL PROTEIN; COLICIN; ENZYME INHIBITOR; NUCLEASE; PROTEIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; BACTERIAL IMMUNITY; BACTERIUM; BINDING AFFINITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; HUMAN; IMMUNITY; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; STRESS; TRANSLATION REGULATION;

BACTERIAL PROTEINS; BINDING SITES; COLICINS; ENZYME INHIBITORS; EVOLUTION; KINETICS; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; MODELS, MOLECULAR;

EID: 0035478958     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(01)01941-7     Document Type: Review

References (55)

1. Natural protein proteinase inhibitors and their interactions with proteinases
2. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
3. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1
4. INK4d
5. Nuclease inhibitors
6. Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: Protein mimicry of DNA
7. Substrate mimicry in the active center of a mammalian α-amylase: Structural analysis of an enzyme-inhibitor complex
8. Bacteriocins, microcins and lantibiotics
9. Colicins and col plasmids
10. Colicin import into Escherichia coli cells
11. Crystal structure of colicin Ia
12. Reversal by trypsin of the inhibition of active transport by colicin E1
13. Colicin A unfolds during its translocation in Escherichia coli cells and spans the whole cell-envelope when its pore has formed
14. 12-dependent E. coli 113/3 cells
15. The biology of E colicins: Paradigms and paradoxes
16. A cytotoxic ribonuclease targeting specific tRNA anticodons
17. Specific inactivation of 16S ribosomal RNA induced by colicin E3 in vivo
18. Colicin E2 is a DNA endonuclease
19. In vivo and in vitro characterisation of overproduced colicin E9 immunity protein
20. Highly purified colicin E3 contains immunity protein
21. Immunity proteins and their specificity for endonuclease colicins: Telling right from wrong in protein-protein recognition
22. Uptake of cloacin DF13 by susceptible cells: Removal of immunity protein and fragmentation of cloacin molecules
23. Protein-protein interactions in colicin E9 DNase-immunity protein complexes. Diffusion controlled association and femtomolar binding for the cognate complex
24. Structural and mechanistic basis of immunity towards endonuclease colicins
25. A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity protein specificity
26. Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9
27. The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein
28. Specificity in protein-protein interactions: The structural basis for dual recognition in colicin endonuclease-immunity protein complexes
29. Inhibition of a ribosome-inactivating ribonuclease: The crystal structure of the cytotoxic domain of colicin E3 in complex with its immunity protein
30. Structural parsimony in endonuclease active sites: Should the number of homing endonuclease families be redefined?
31. 13C NMR assignments of the colicin E9 immunity protein Im9
32. Crystal structure of colicin E3 immunity protein: An inhibitor of a ribosome-inactivating RNase
33. Identification of putative active-site residues in the DNase domain of colicin E9 by random mutagenesis
34. Subsite binding in an RNase: Structure of a barnase-tetranucleotide complex at 1.76 Å resolution
35. Protein-protein recognition: Crystal structural analysis of a barnase-barstar complex at 2.0 Å resolution
36. Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
37. Triabin, a highly potent exosite inhibitor of thrombin
38. Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug
39. Partial characterization of vertebrate prothrombin cDNAs: Amplification and sequence analysis of the B chain of thrombin from nine different species
40. Co-translational folding of an α-virus capsid protein in the cytosol of living cells
41. Nascent polypeptide chains exit the ribosome in the same relative position in both eukaryotes and prokaryotes
42. Nucleotide polymorphism in colicin E2 clusters: Evidence for nonneutral evolution
43. Molecular mechanisms of bacteriocin evolution
44. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: An overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of exogenous treatment to damage DNA
45. Dual recognition and the role of specificity-determining residues in colicin E9 DNase-immunity protein interactions
46. Identification of a unique specificity determinant of the colicin E3 immunity protein
47. Specificity in protein-protein recognition: Conserved Im9 residues are the major determinants of stability in the colicin E9 DNase-Im9 complex
48. Protein-protein interactions in colicin E9 DNase-immunity protein complexes. Cognate and noncognate interactions that span the millimolar to femtomolar affinity range
49. Structure of the heterodimeric complex between CAD domains of CAD and ICAD
50. Enzymatic active site of caspase-activated DNase (CAD) and its inhibition by inhibitor of CAD
51. Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNase
52. The best offense is a good defense
53. The SOS response of Escherichia coli
54. Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase
55. The atomic structure of protein-protein recognition sites