-
1
-
-
0000074870
-
Strategy and tactics in combinatorial organic synthesis. Applications to drug discovery
-
Gordon, E. M.; Gallop, M. A.; Patel, D. V. Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery. Acc. Chem. Res. 1996, 29, 144-154.
-
(1996)
Acc. Chem. Res.
, vol.29
, pp. 144-154
-
-
Gordon, E.M.1
Gallop, M.A.2
Patel, D.V.3
-
3
-
-
0031152153
-
New methods for analyzing compounds on polymeric supports
-
Gallop, M. A.; Fitch, W. L. New methods for analyzing compounds on polymeric supports. Curr. Opin. Chem. Biol. 1997, 1, 94-100.
-
(1997)
Curr. Opin. Chem. Biol.
, vol.1
, pp. 94-100
-
-
Gallop, M.A.1
Fitch, W.L.2
-
4
-
-
0030764736
-
Direct monitoring of organic reactions on polymeric supports
-
Carrasco, M. R.; Fitzgerald, M. C.; Oda, Y.; Kent, S. B. H. Direct Monitoring of Organic Reactions on Polymeric Supports. Tetrahedron Lett. 1997, 38, 6331-6334.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 6331-6334
-
-
Carrasco, M.R.1
Fitzgerald, M.C.2
Oda, Y.3
Kent, S.B.H.4
-
5
-
-
0031104423
-
Analytical techniques for solid-phase organic and combinatorial synthesis
-
Egner, B. J.; Bradley, M. Analytical Techniques for Solid-Phase Organic and Combinatorial Synthesis. Drug Discovery Today 1997, 2 (3), 102-109.
-
(1997)
Drug Discovery Today
, vol.2
, Issue.3
, pp. 102-109
-
-
Egner, B.J.1
Bradley, M.2
-
6
-
-
0000008711
-
High-resolution 1h NMR in solid-phase organic synthesis
-
Fitch, W. L.; Detre, G.; Holmes, C. P.; Shoolery, J. N.; Keifer, P. A. High-Resolution 1H NMR in Solid-Phase Organic Synthesis. J. Org. Chem. 1994, 59, 7955-7956.
-
(1994)
J. Org. Chem.
, vol.59
, pp. 7955-7956
-
-
Fitch, W.L.1
Detre, G.2
Holmes, C.P.3
Shoolery, J.N.4
Keifer, P.A.5
-
7
-
-
0002108435
-
A comparison of NMR spectra obtained for solid-phase-synthesis resins using conventional high-resolution, magic-angle-spinning, and high-resolution magic-angle-spinning probes
-
Keifer, P. A.; Baltusis, L.; Rice, D. M.; Tymiak, A. A.; Shoolery, J. N. A Comparison of NMR Spectra Obtained for Solid-Phase-Synthesis Resins Using Conventional High-Resolution, Magic-Angle-Spinning, and High-Resolution Magic-Angle-Spinning Probes. J. Magn. Reson. A 1996, 119, 65-75.
-
(1996)
J. Magn. Reson. A
, vol.119
, pp. 65-75
-
-
Keifer, P.A.1
Baltusis, L.2
Rice, D.M.3
Tymiak, A.A.4
Shoolery, J.N.5
-
8
-
-
0000012760
-
Influence of resin structure, tether length, and solvent upon the high-resolution 1H NMR spectra of solid-phase-synthesis resins
-
Keifer, P. A. Influence of Resin Structure, Tether Length, and Solvent upon the High-Resolution 1H NMR Spectra of Solid-Phase-Synthesis Resins. J. Org. Chem. 1996, 61, 1558-1559.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 1558-1559
-
-
Keifer, P.A.1
-
9
-
-
0029871215
-
An NMR method to identify nondestructively chemical compounds bound to a single solid-phase-synthesis bead for combinatorial chemistry applications
-
Sarkar, S. K.; Garigipati, R. S.; Adams, J. L.; Keifer, P. A. An NMR Method To Identify Nondestructively Chemical Compounds Bound to a Single Solid-Phase-Synthesis Bead for Combinatorial Chemistry Applications. J. Am. Chem. Soc. 1996, 118, 2305-2306.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2305-2306
-
-
Sarkar, S.K.1
Garigipati, R.S.2
Adams, J.L.3
Keifer, P.A.4
-
10
-
-
0000942356
-
Use of spin-echo magic angle spinning 1H NMR in reaction monitoring in combinatorial organic synthesis
-
Garigipati, R. S.; Adams, B.; Adams, J. L.; Sarkar, S. K. Use of Spin-Echo Magic Angle Spinning 1H NMR in Reaction Monitoring in Combinatorial Organic Synthesis. J. Org. Chem. 1996, 61, 2911-2914.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 2911-2914
-
-
Garigipati, R.S.1
Adams, B.2
Adams, J.L.3
Sarkar, S.K.4
-
11
-
-
0030869479
-
High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry
-
Keifer, P. A. High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry. Drug Discovery Today 1997, 2, 468-478.
-
(1997)
Drug Discovery Today
, vol.2
, pp. 468-478
-
-
Keifer, P.A.1
-
12
-
-
0032943579
-
NMR tools for biotechnology
-
Keifer, P. A. NMR Tools for Biotechnology. Curr. Opin. Biotechnol. 1999, 10 (1), 34-41.
-
(1999)
Curr. Opin. Biotechnol.
, vol.10
, Issue.1
, pp. 34-41
-
-
Keifer, P.A.1
-
13
-
-
0031896915
-
New methods for obtaining high-resolution NMR spectra of solid-phase synthesis resins, natural products, and solution-state combinatorial chemistry libraries
-
Keifer, P. A. New methods for obtaining high-resolution NMR spectra of solid-phase synthesis resins, natural products, and solution-state combinatorial chemistry libraries. Drugs Future 1998, 23, 301-317.
-
(1998)
Drugs Future
, vol.23
, pp. 301-317
-
-
Keifer, P.A.1
-
14
-
-
58149365344
-
WET solvent suppression and its applications to LC NMR and high-resolution NMR spectroscopy
-
Smallcombe, S. H.; Patt, S. L.; Keifer, P. A. WET Solvent Suppression and its Applications to LC NMR and High-Resolution NMR Spectroscopy. J. Magn. Reson. A 1995, 117, 295-303.
-
(1995)
J. Magn. Reson. A
, vol.117
, pp. 295-303
-
-
Smallcombe, S.H.1
Patt, S.L.2
Keifer, P.A.3
-
15
-
-
0040462571
-
-
US Patent 5,847,564, 1998
-
Smallcombe, S. H.; Patt, S. L.; Keifer, P. A. Solvent Suppression Method for LC-NMR and High-Resolution NMR. US Patent 5,847,564, 1998.
-
Solvent Suppression Method for LC-NMR and High-Resolution NMR
-
-
Smallcombe, S.H.1
Patt, S.L.2
Keifer, P.A.3
-
16
-
-
25944434129
-
New NMR tools for combinatorial chemistry including solid-phase-synthesis-resin NMR and high-throughput spectroscopy
-
San Francisco, April 13-17 1997, ORGN-277; American Chemical Society: Washington, DC
-
Keifer, P. A. New NMR tools for combinatorial chemistry including solid-phase-synthesis-resin NMR and high-throughput spectroscopy. In Book of Abstracts; 213th ACS National Meeting, San Francisco, April 13-17 1997, ORGN-277; American Chemical Society: Washington, DC, 1997; pp ORGN-277.
-
(1997)
Book of Abstracts; 213th ACS National Meeting
-
-
Keifer, P.A.1
-
17
-
-
0031083295
-
Automated shimming for deuterated solvents using field profiling
-
Sukumar, S.; Johnson, M. O. N.; Hurd, R. E.; Van Zijl, P. C. M. Automated Shimming for Deuterated Solvents Using Field Profiling. J. Magn. Reson. 1997, 125, 159-162.
-
(1997)
J. Magn. Reson.
, vol.125
, pp. 159-162
-
-
Sukumar, S.1
Johnson, M.O.N.2
Hurd, R.E.3
Van Zijl, P.C.M.4
-
18
-
-
0006756004
-
Selective detection in NMR by time-domain digital filtering
-
Rosen, M. E. Selective Detection in NMR by Time-Domain Digital Filtering. J. Magn. Reson. A 1994, 107, 119-125.
-
(1994)
J. Magn. Reson. A
, vol.107
, pp. 119-125
-
-
Rosen, M.E.1
-
19
-
-
0039277886
-
-
Gilson, Inc., 3000 W. Beltline Hwy, P.O. Box 620027, Middleton, WI 53562, USA, 1-(800)-445-7661
-
Gilson, Inc., 3000 W. Beltline Hwy, P.O. Box 620027, Middleton, WI 53562, USA, 1-(800)-445-7661.
-
-
-
-
20
-
-
0040462635
-
-
Varian NMR Systems, Palo Alto, CA, USA
-
Varian NMR Systems, Palo Alto, CA, USA; www.varianinc.com.
-
-
-
-
21
-
-
0041056621
-
-
Sun Microsystems, Inc., 901 San Antonio Rd., Palo Alto, CA 94303, USA
-
Sun Microsystems, Inc., 901 San Antonio Rd., Palo Alto, CA 94303, USA.
-
-
-
-
22
-
-
0004310225
-
-
including VAST software package
-
Varian NMR Systems, VNMR 6.1B Software, including VAST software package.
-
VNMR 6.1B Software
-
-
-
23
-
-
0039869652
-
-
National Scientific, 975 Progress Circle, Lawrenceville, GA 30043, (770)-995-7622, Part No. C4013-4045
-
National Scientific, 975 Progress Circle, Lawrenceville, GA 30043, (770)-995-7622, Part No. C4013-4045.
-
-
-
-
24
-
-
0039869654
-
Flow injection analysis NMR (FIA-NMR) - A novel flow NMR technique that complements LC-NMR and direct injection NMR (DI-NMR)
-
in press
-
Keifer, P. A. Flow Injection Analysis NMR (FIA-NMR) - A Novel Flow NMR Technique that Complements LC-NMR and Direct Injection NMR (DI-NMR). Magn. Reson. Chem. 2000, in press.
-
(2000)
Magn. Reson. Chem.
-
-
Keifer, P.A.1
-
27
-
-
44049124733
-
Single- and multiple-frequency-shifted laminar pulses
-
Patt, S. L. Single- and Multiple-Frequency-Shifted Laminar Pulses. J. Magn. Reson. 1992, 96, 94-102.
-
(1992)
J. Magn. Reson.
, vol.96
, pp. 94-102
-
-
Patt, S.L.1
-
28
-
-
12044251259
-
Solvent suppression with symmetrically-shifted pulses
-
Smallcombe, S. H. Solvent Suppression with Symmetrically-Shifted Pulses. J. Am. Chem. Soc. 1993, 115, 4776-4785.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 4776-4785
-
-
Smallcombe, S.H.1
-
29
-
-
0000737629
-
The nuclear magnetization as the origin of transient changes in the magnetic field in pulsed NMR experiments
-
Edzes, H. T. The Nuclear Magnetization as the Origin of Transient Changes in the Magnetic Field in Pulsed NMR Experiments. J. Magn. Reson. 1990, 86, 293-303.
-
(1990)
J. Magn. Reson.
, vol.86
, pp. 293-303
-
-
Edzes, H.T.1
-
30
-
-
0039277831
-
-
Sphinx Pharmaceuticals, Research Triangle Park, NC 27709, USA, unpublished results
-
Philip F. Hughes, Sphinx Pharmaceuticals, Research Triangle Park, NC 27709, USA, unpublished results.
-
-
-
Hughes, P.F.1
-
31
-
-
0037506563
-
High-throughput flow injection analysis mass spectrometry with networked delivery of color-rendered results. 2. Three-dimensional spectral mapping of 96-well combinatorial chemistry racks
-
Gorlach, E.; Richmond, R.; Lewis, I. High-Throughput Flow Injection Analysis Mass Spectrometry with Networked Delivery of Color-Rendered Results. 2. Three-Dimensional Spectral Mapping of 96-Well Combinatorial Chemistry Racks. Anal. Chem. 1998, 70, 3227-3234.
-
(1998)
Anal. Chem.
, vol.70
, pp. 3227-3234
-
-
Gorlach, E.1
Richmond, R.2
Lewis, I.3
-
32
-
-
0041056567
-
-
Glaxo-Wellcome, Research Triangle Park, NC, unpublished results
-
Timothy D. Spitzer, Glaxo-Wellcome, Research Triangle Park, NC, unpublished results.
-
-
-
Spitzer, T.D.1
-
33
-
-
0040462570
-
-
ACD/Labs, 133 Richmond St. West, Suite 605, Toronto, Ontario, M5H 2L3, Canada
-
ACD/Labs, 133 Richmond St. West, Suite 605, Toronto, Ontario, M5H 2L3, Canada; www.acdlabs.com.
-
-
-
-
34
-
-
0007417080
-
Comparison of fourier and bayesian analysis of NMR signals. II. Examination of truncated free induction decay NMR data
-
Kotyk, J. J.; Hoffman, N. G.; Hutton, W. C.; Bretthorst, G. L.; Ackerman, J. J. H. Comparison of Fourier and Bayesian analysis of NMR signals. II. Examination of truncated free induction decay NMR data. J. Magn. Reson. 1995, 116, 1-9.
-
(1995)
J. Magn. Reson.
, vol.116
, pp. 1-9
-
-
Kotyk, J.J.1
Hoffman, N.G.2
Hutton, W.C.3
Bretthorst, G.L.4
Ackerman, J.J.H.5
-
35
-
-
44949266852
-
Bayesian analysis. III. Applications to NMR signal detection, model selection, and parameter estimation
-
Bretthorst, G. L. Bayesian analysis. III. Applications to NMR signal detection, model selection, and parameter estimation. J. Magn. Reson. 1990, 88, 571-595.
-
(1990)
J. Magn. Reson.
, vol.88
, pp. 571-595
-
-
Bretthorst, G.L.1
-
36
-
-
0002316638
-
Proton chemical-shift spectra
-
Simova, S.; Sengstschmid, H.; Freeman, R. Proton Chemical-Shift Spectra. J. Magn. Reson. 1997, 124, 104-121.
-
(1997)
J. Magn. Reson.
, vol.124
, pp. 104-121
-
-
Simova, S.1
Sengstschmid, H.2
Freeman, R.3
-
37
-
-
0032165891
-
Reference deconvolution, phase correction, and line listing of NMR spectra by the 1D filter diagonalization methodol
-
Hu, H.; Van, Q. N.; Mandelshtam, V. A.; Shaka, A. J. Reference Deconvolution, Phase Correction, and Line Listing of NMR Spectra by the 1D Filter Diagonalization Methodol. J. Magn. Reson. 1998, 134, 76-87.
-
(1998)
J. Magn. Reson.
, vol.134
, pp. 76-87
-
-
Hu, H.1
Van, Q.N.2
Mandelshtam, V.A.3
Shaka, A.J.4
-
38
-
-
0032567219
-
Obtaining proton chemical shifts and multiplets from several 1d nmr signals
-
Mandelshtam, V. A.; Van, Q. N.; Shaka, A. J. Obtaining Proton Chemical Shifts and Multiplets from Several 1D NMR Signals. J. Am. Chem. Soc. 1998, 120, 12161-12162.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 12161-12162
-
-
Mandelshtam, V.A.1
Van, Q.N.2
Shaka, A.J.3
-
39
-
-
0000188085
-
Application of the filter diagonalization method to one- and two-dimensional NMR spectra
-
Mandelshtam, V. A.; Taylor, H. S.; Shaka, A. J. Application of the filter diagonalization method to one- and two-dimensional NMR spectra. J. Magn. Reson. 1998, 133, 304-312.
-
(1998)
J. Magn. Reson.
, vol.133
, pp. 304-312
-
-
Mandelshtam, V.A.1
Taylor, H.S.2
Shaka, A.J.3
-
40
-
-
0031576702
-
One-dimensional relaxation- and diffusion-edited NMR methods for screening compounds that bind to macromolecules
-
Hajduk, P. J.; Olejniczak, E. T.; Fesik, S. W. One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds that Bind to Macromolecules. J. Am. Chem. Soc. 1997, 119, 12257-12261.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 12257-12261
-
-
Hajduk, P.J.1
Olejniczak, E.T.2
Fesik, S.W.3
-
41
-
-
0001174635
-
Diffusion-edited NMR - Affinity NMR for direct observation of molecular interactions
-
Lin, M.; Shapiro, M. J.; Wareing, J. R. Diffusion-Edited NMR - Affinity NMR for Direct Observation of Molecular Interactions. J. Am. Chem. Soc. 1997, 119, 5249-5250.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 5249-5250
-
-
Lin, M.1
Shapiro, M.J.2
Wareing, J.R.3
-
42
-
-
0032559292
-
Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents
-
Wolfender, J.-L.; Rodriguez, S.; Hostettmann, K. Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents. J. Chromatogr. 1998, 794, 299-316.
-
(1998)
J. Chromatogr.
, vol.794
, pp. 299-316
-
-
Wolfender, J.-L.1
Rodriguez, S.2
Hostettmann, K.3
-
43
-
-
0000673856
-
Resolution of discrete and continuous molecular size distributions by means of diffusion-ordered 2D NMR spectroscopy
-
Morris, K. F.; Johnson, C. S., Jr. Resolution of discrete and continuous molecular size distributions by means of diffusion-ordered 2D NMR spectroscopy. J. Am. Chem. Soc. 1993, 115, 4291-4299.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 4291-4299
-
-
Morris, K.F.1
Johnson C.S., Jr.2
-
44
-
-
0001002874
-
High-resolution diffusion-ordered 2D spectroscopy (HR-DOSY) - A new tool for the analysis of complex mixtures
-
Barjat, H.; Morris, G. A.; Smart, S.; Swanson, A. G.; Williams, S. C. R. High-resolution diffusion-ordered 2D spectroscopy (HR-DOSY) - A new tool for the analysis of complex mixtures. J. Magn. Reson. B. 1995, 108, 170-172.
-
(1995)
J. Magn. Reson. B.
, vol.108
, pp. 170-172
-
-
Barjat, H.1
Morris, G.A.2
Smart, S.3
Swanson, A.G.4
Williams, S.C.R.5
-
45
-
-
0001467391
-
Isotope-filtered affinity NMR
-
Gonnella, N.; Lin, M.; Shapiro, M. J.; Wareing, J. R.; Zhang, X. Isotope-Filtered Affinity NMR. J. Magn. Reson. 1998, 131, 336-338.
-
(1998)
J. Magn. Reson.
, vol.131
, pp. 336-338
-
-
Gonnella, N.1
Lin, M.2
Shapiro, M.J.3
Wareing, J.R.4
Zhang, X.5
-
46
-
-
0001448626
-
Mixture analysis in combinatorial chemistry. Application of diffusion-resolved NMR spectroscopy
-
Lin, M.; Shapiro, M. J. Mixture Analysis in Combinatorial Chemistry. Application of Diffusion-Resolved NMR Spectroscopy. J. Org. Chem. 1996, 61, 7617-7619.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 7617-7619
-
-
Lin, M.1
Shapiro, M.J.2
-
47
-
-
0029836953
-
Discovering high-affinity ligands for proteins: SAR by NMR
-
Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.; Fesik, S. W. Discovering High-Affinity Ligands for Proteins: SAR by NMR. Science 1996, 274, 1531-1534.
-
(1996)
Science
, vol.274
, pp. 1531-1534
-
-
Shuker, S.B.1
Hajduk, P.J.2
Meadows, R.P.3
Fesik, S.W.4
-
49
-
-
0033403649
-
Shape-selective recognition of a model okazaki fragment by geometrically-constrained bis-distamycins
-
in press
-
Gmeiner, W. H.; Cui, W.; Konerding, D. E.; Keifer, P. A.; Sharma, S. K.; Soto, A. M.; Marky, L. A.; Lown, J. W. Shape-Selective Recognition of a Model Okazaki Fragment by Geometrically-Constrained Bis-Distamycins. J. Biomol. Struct. Dynam. 1999, 17, in press.
-
(1999)
J. Biomol. Struct. Dynam.
, vol.17
-
-
Gmeiner, W.H.1
Cui, W.2
Konerding, D.E.3
Keifer, P.A.4
Sharma, S.K.5
Soto, A.M.6
Marky, L.A.7
Lown, J.W.8
-
50
-
-
0001294727
-
High-throughput 1H NMR and HPLC characterization of a 96-member substituted methylene malonamic acid library
-
Hamper, B. C.; Synderman, D. M.; Owen, T. J.; Scates, A. M.; Owsley, D. C.; Kesselring, A. S.; Chott, R. C. High-Throughput 1H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library. J. Comb. Chem. 1999, 1, 140-150.
-
(1999)
J. Comb. Chem.
, vol.1
, pp. 140-150
-
-
Hamper, B.C.1
Synderman, D.M.2
Owen, T.J.3
Scates, A.M.4
Owsley, D.C.5
Kesselring, A.S.6
Chott, R.C.7
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