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Volumn 2, Issue 2, 2000, Pages 151-171

Direct-injection NMR (DI-NMR): A flow NMR technique for the analysis of combinatorial chemistry libraries

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; SOLVENT;

EID: 0034154192     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc990066u     Document Type: Article
Times cited : (64)

References (50)
  • 1
    • 0000074870 scopus 로고    scopus 로고
    • Strategy and tactics in combinatorial organic synthesis. Applications to drug discovery
    • Gordon, E. M.; Gallop, M. A.; Patel, D. V. Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery. Acc. Chem. Res. 1996, 29, 144-154.
    • (1996) Acc. Chem. Res. , vol.29 , pp. 144-154
    • Gordon, E.M.1    Gallop, M.A.2    Patel, D.V.3
  • 3
    • 0031152153 scopus 로고    scopus 로고
    • New methods for analyzing compounds on polymeric supports
    • Gallop, M. A.; Fitch, W. L. New methods for analyzing compounds on polymeric supports. Curr. Opin. Chem. Biol. 1997, 1, 94-100.
    • (1997) Curr. Opin. Chem. Biol. , vol.1 , pp. 94-100
    • Gallop, M.A.1    Fitch, W.L.2
  • 4
    • 0030764736 scopus 로고    scopus 로고
    • Direct monitoring of organic reactions on polymeric supports
    • Carrasco, M. R.; Fitzgerald, M. C.; Oda, Y.; Kent, S. B. H. Direct Monitoring of Organic Reactions on Polymeric Supports. Tetrahedron Lett. 1997, 38, 6331-6334.
    • (1997) Tetrahedron Lett. , vol.38 , pp. 6331-6334
    • Carrasco, M.R.1    Fitzgerald, M.C.2    Oda, Y.3    Kent, S.B.H.4
  • 5
    • 0031104423 scopus 로고    scopus 로고
    • Analytical techniques for solid-phase organic and combinatorial synthesis
    • Egner, B. J.; Bradley, M. Analytical Techniques for Solid-Phase Organic and Combinatorial Synthesis. Drug Discovery Today 1997, 2 (3), 102-109.
    • (1997) Drug Discovery Today , vol.2 , Issue.3 , pp. 102-109
    • Egner, B.J.1    Bradley, M.2
  • 7
    • 0002108435 scopus 로고    scopus 로고
    • A comparison of NMR spectra obtained for solid-phase-synthesis resins using conventional high-resolution, magic-angle-spinning, and high-resolution magic-angle-spinning probes
    • Keifer, P. A.; Baltusis, L.; Rice, D. M.; Tymiak, A. A.; Shoolery, J. N. A Comparison of NMR Spectra Obtained for Solid-Phase-Synthesis Resins Using Conventional High-Resolution, Magic-Angle-Spinning, and High-Resolution Magic-Angle-Spinning Probes. J. Magn. Reson. A 1996, 119, 65-75.
    • (1996) J. Magn. Reson. A , vol.119 , pp. 65-75
    • Keifer, P.A.1    Baltusis, L.2    Rice, D.M.3    Tymiak, A.A.4    Shoolery, J.N.5
  • 8
    • 0000012760 scopus 로고    scopus 로고
    • Influence of resin structure, tether length, and solvent upon the high-resolution 1H NMR spectra of solid-phase-synthesis resins
    • Keifer, P. A. Influence of Resin Structure, Tether Length, and Solvent upon the High-Resolution 1H NMR Spectra of Solid-Phase-Synthesis Resins. J. Org. Chem. 1996, 61, 1558-1559.
    • (1996) J. Org. Chem. , vol.61 , pp. 1558-1559
    • Keifer, P.A.1
  • 9
    • 0029871215 scopus 로고    scopus 로고
    • An NMR method to identify nondestructively chemical compounds bound to a single solid-phase-synthesis bead for combinatorial chemistry applications
    • Sarkar, S. K.; Garigipati, R. S.; Adams, J. L.; Keifer, P. A. An NMR Method To Identify Nondestructively Chemical Compounds Bound to a Single Solid-Phase-Synthesis Bead for Combinatorial Chemistry Applications. J. Am. Chem. Soc. 1996, 118, 2305-2306.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 2305-2306
    • Sarkar, S.K.1    Garigipati, R.S.2    Adams, J.L.3    Keifer, P.A.4
  • 10
    • 0000942356 scopus 로고    scopus 로고
    • Use of spin-echo magic angle spinning 1H NMR in reaction monitoring in combinatorial organic synthesis
    • Garigipati, R. S.; Adams, B.; Adams, J. L.; Sarkar, S. K. Use of Spin-Echo Magic Angle Spinning 1H NMR in Reaction Monitoring in Combinatorial Organic Synthesis. J. Org. Chem. 1996, 61, 2911-2914.
    • (1996) J. Org. Chem. , vol.61 , pp. 2911-2914
    • Garigipati, R.S.1    Adams, B.2    Adams, J.L.3    Sarkar, S.K.4
  • 11
    • 0030869479 scopus 로고    scopus 로고
    • High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry
    • Keifer, P. A. High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry. Drug Discovery Today 1997, 2, 468-478.
    • (1997) Drug Discovery Today , vol.2 , pp. 468-478
    • Keifer, P.A.1
  • 12
    • 0032943579 scopus 로고    scopus 로고
    • NMR tools for biotechnology
    • Keifer, P. A. NMR Tools for Biotechnology. Curr. Opin. Biotechnol. 1999, 10 (1), 34-41.
    • (1999) Curr. Opin. Biotechnol. , vol.10 , Issue.1 , pp. 34-41
    • Keifer, P.A.1
  • 13
    • 0031896915 scopus 로고    scopus 로고
    • New methods for obtaining high-resolution NMR spectra of solid-phase synthesis resins, natural products, and solution-state combinatorial chemistry libraries
    • Keifer, P. A. New methods for obtaining high-resolution NMR spectra of solid-phase synthesis resins, natural products, and solution-state combinatorial chemistry libraries. Drugs Future 1998, 23, 301-317.
    • (1998) Drugs Future , vol.23 , pp. 301-317
    • Keifer, P.A.1
  • 14
    • 58149365344 scopus 로고
    • WET solvent suppression and its applications to LC NMR and high-resolution NMR spectroscopy
    • Smallcombe, S. H.; Patt, S. L.; Keifer, P. A. WET Solvent Suppression and its Applications to LC NMR and High-Resolution NMR Spectroscopy. J. Magn. Reson. A 1995, 117, 295-303.
    • (1995) J. Magn. Reson. A , vol.117 , pp. 295-303
    • Smallcombe, S.H.1    Patt, S.L.2    Keifer, P.A.3
  • 16
    • 25944434129 scopus 로고    scopus 로고
    • New NMR tools for combinatorial chemistry including solid-phase-synthesis-resin NMR and high-throughput spectroscopy
    • San Francisco, April 13-17 1997, ORGN-277; American Chemical Society: Washington, DC
    • Keifer, P. A. New NMR tools for combinatorial chemistry including solid-phase-synthesis-resin NMR and high-throughput spectroscopy. In Book of Abstracts; 213th ACS National Meeting, San Francisco, April 13-17 1997, ORGN-277; American Chemical Society: Washington, DC, 1997; pp ORGN-277.
    • (1997) Book of Abstracts; 213th ACS National Meeting
    • Keifer, P.A.1
  • 17
    • 0031083295 scopus 로고    scopus 로고
    • Automated shimming for deuterated solvents using field profiling
    • Sukumar, S.; Johnson, M. O. N.; Hurd, R. E.; Van Zijl, P. C. M. Automated Shimming for Deuterated Solvents Using Field Profiling. J. Magn. Reson. 1997, 125, 159-162.
    • (1997) J. Magn. Reson. , vol.125 , pp. 159-162
    • Sukumar, S.1    Johnson, M.O.N.2    Hurd, R.E.3    Van Zijl, P.C.M.4
  • 18
    • 0006756004 scopus 로고
    • Selective detection in NMR by time-domain digital filtering
    • Rosen, M. E. Selective Detection in NMR by Time-Domain Digital Filtering. J. Magn. Reson. A 1994, 107, 119-125.
    • (1994) J. Magn. Reson. A , vol.107 , pp. 119-125
    • Rosen, M.E.1
  • 19
    • 0039277886 scopus 로고    scopus 로고
    • Gilson, Inc., 3000 W. Beltline Hwy, P.O. Box 620027, Middleton, WI 53562, USA, 1-(800)-445-7661
    • Gilson, Inc., 3000 W. Beltline Hwy, P.O. Box 620027, Middleton, WI 53562, USA, 1-(800)-445-7661.
  • 20
    • 0040462635 scopus 로고    scopus 로고
    • Varian NMR Systems, Palo Alto, CA, USA
    • Varian NMR Systems, Palo Alto, CA, USA; www.varianinc.com.
  • 21
    • 0041056621 scopus 로고    scopus 로고
    • Sun Microsystems, Inc., 901 San Antonio Rd., Palo Alto, CA 94303, USA
    • Sun Microsystems, Inc., 901 San Antonio Rd., Palo Alto, CA 94303, USA.
  • 22
    • 0004310225 scopus 로고    scopus 로고
    • including VAST software package
    • Varian NMR Systems, VNMR 6.1B Software, including VAST software package.
    • VNMR 6.1B Software
  • 23
    • 0039869652 scopus 로고    scopus 로고
    • National Scientific, 975 Progress Circle, Lawrenceville, GA 30043, (770)-995-7622, Part No. C4013-4045
    • National Scientific, 975 Progress Circle, Lawrenceville, GA 30043, (770)-995-7622, Part No. C4013-4045.
  • 24
    • 0039869654 scopus 로고    scopus 로고
    • Flow injection analysis NMR (FIA-NMR) - A novel flow NMR technique that complements LC-NMR and direct injection NMR (DI-NMR)
    • in press
    • Keifer, P. A. Flow Injection Analysis NMR (FIA-NMR) - A Novel Flow NMR Technique that Complements LC-NMR and Direct Injection NMR (DI-NMR). Magn. Reson. Chem. 2000, in press.
    • (2000) Magn. Reson. Chem.
    • Keifer, P.A.1
  • 27
    • 44049124733 scopus 로고
    • Single- and multiple-frequency-shifted laminar pulses
    • Patt, S. L. Single- and Multiple-Frequency-Shifted Laminar Pulses. J. Magn. Reson. 1992, 96, 94-102.
    • (1992) J. Magn. Reson. , vol.96 , pp. 94-102
    • Patt, S.L.1
  • 28
    • 12044251259 scopus 로고
    • Solvent suppression with symmetrically-shifted pulses
    • Smallcombe, S. H. Solvent Suppression with Symmetrically-Shifted Pulses. J. Am. Chem. Soc. 1993, 115, 4776-4785.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 4776-4785
    • Smallcombe, S.H.1
  • 29
    • 0000737629 scopus 로고
    • The nuclear magnetization as the origin of transient changes in the magnetic field in pulsed NMR experiments
    • Edzes, H. T. The Nuclear Magnetization as the Origin of Transient Changes in the Magnetic Field in Pulsed NMR Experiments. J. Magn. Reson. 1990, 86, 293-303.
    • (1990) J. Magn. Reson. , vol.86 , pp. 293-303
    • Edzes, H.T.1
  • 30
    • 0039277831 scopus 로고    scopus 로고
    • Sphinx Pharmaceuticals, Research Triangle Park, NC 27709, USA, unpublished results
    • Philip F. Hughes, Sphinx Pharmaceuticals, Research Triangle Park, NC 27709, USA, unpublished results.
    • Hughes, P.F.1
  • 31
    • 0037506563 scopus 로고    scopus 로고
    • High-throughput flow injection analysis mass spectrometry with networked delivery of color-rendered results. 2. Three-dimensional spectral mapping of 96-well combinatorial chemistry racks
    • Gorlach, E.; Richmond, R.; Lewis, I. High-Throughput Flow Injection Analysis Mass Spectrometry with Networked Delivery of Color-Rendered Results. 2. Three-Dimensional Spectral Mapping of 96-Well Combinatorial Chemistry Racks. Anal. Chem. 1998, 70, 3227-3234.
    • (1998) Anal. Chem. , vol.70 , pp. 3227-3234
    • Gorlach, E.1    Richmond, R.2    Lewis, I.3
  • 32
    • 0041056567 scopus 로고    scopus 로고
    • Glaxo-Wellcome, Research Triangle Park, NC, unpublished results
    • Timothy D. Spitzer, Glaxo-Wellcome, Research Triangle Park, NC, unpublished results.
    • Spitzer, T.D.1
  • 33
    • 0040462570 scopus 로고    scopus 로고
    • ACD/Labs, 133 Richmond St. West, Suite 605, Toronto, Ontario, M5H 2L3, Canada
    • ACD/Labs, 133 Richmond St. West, Suite 605, Toronto, Ontario, M5H 2L3, Canada; www.acdlabs.com.
  • 34
    • 0007417080 scopus 로고
    • Comparison of fourier and bayesian analysis of NMR signals. II. Examination of truncated free induction decay NMR data
    • Kotyk, J. J.; Hoffman, N. G.; Hutton, W. C.; Bretthorst, G. L.; Ackerman, J. J. H. Comparison of Fourier and Bayesian analysis of NMR signals. II. Examination of truncated free induction decay NMR data. J. Magn. Reson. 1995, 116, 1-9.
    • (1995) J. Magn. Reson. , vol.116 , pp. 1-9
    • Kotyk, J.J.1    Hoffman, N.G.2    Hutton, W.C.3    Bretthorst, G.L.4    Ackerman, J.J.H.5
  • 35
    • 44949266852 scopus 로고
    • Bayesian analysis. III. Applications to NMR signal detection, model selection, and parameter estimation
    • Bretthorst, G. L. Bayesian analysis. III. Applications to NMR signal detection, model selection, and parameter estimation. J. Magn. Reson. 1990, 88, 571-595.
    • (1990) J. Magn. Reson. , vol.88 , pp. 571-595
    • Bretthorst, G.L.1
  • 37
    • 0032165891 scopus 로고    scopus 로고
    • Reference deconvolution, phase correction, and line listing of NMR spectra by the 1D filter diagonalization methodol
    • Hu, H.; Van, Q. N.; Mandelshtam, V. A.; Shaka, A. J. Reference Deconvolution, Phase Correction, and Line Listing of NMR Spectra by the 1D Filter Diagonalization Methodol. J. Magn. Reson. 1998, 134, 76-87.
    • (1998) J. Magn. Reson. , vol.134 , pp. 76-87
    • Hu, H.1    Van, Q.N.2    Mandelshtam, V.A.3    Shaka, A.J.4
  • 38
    • 0032567219 scopus 로고    scopus 로고
    • Obtaining proton chemical shifts and multiplets from several 1d nmr signals
    • Mandelshtam, V. A.; Van, Q. N.; Shaka, A. J. Obtaining Proton Chemical Shifts and Multiplets from Several 1D NMR Signals. J. Am. Chem. Soc. 1998, 120, 12161-12162.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 12161-12162
    • Mandelshtam, V.A.1    Van, Q.N.2    Shaka, A.J.3
  • 39
    • 0000188085 scopus 로고    scopus 로고
    • Application of the filter diagonalization method to one- and two-dimensional NMR spectra
    • Mandelshtam, V. A.; Taylor, H. S.; Shaka, A. J. Application of the filter diagonalization method to one- and two-dimensional NMR spectra. J. Magn. Reson. 1998, 133, 304-312.
    • (1998) J. Magn. Reson. , vol.133 , pp. 304-312
    • Mandelshtam, V.A.1    Taylor, H.S.2    Shaka, A.J.3
  • 40
    • 0031576702 scopus 로고    scopus 로고
    • One-dimensional relaxation- and diffusion-edited NMR methods for screening compounds that bind to macromolecules
    • Hajduk, P. J.; Olejniczak, E. T.; Fesik, S. W. One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds that Bind to Macromolecules. J. Am. Chem. Soc. 1997, 119, 12257-12261.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 12257-12261
    • Hajduk, P.J.1    Olejniczak, E.T.2    Fesik, S.W.3
  • 41
    • 0001174635 scopus 로고    scopus 로고
    • Diffusion-edited NMR - Affinity NMR for direct observation of molecular interactions
    • Lin, M.; Shapiro, M. J.; Wareing, J. R. Diffusion-Edited NMR - Affinity NMR for Direct Observation of Molecular Interactions. J. Am. Chem. Soc. 1997, 119, 5249-5250.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 5249-5250
    • Lin, M.1    Shapiro, M.J.2    Wareing, J.R.3
  • 42
    • 0032559292 scopus 로고    scopus 로고
    • Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents
    • Wolfender, J.-L.; Rodriguez, S.; Hostettmann, K. Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents. J. Chromatogr. 1998, 794, 299-316.
    • (1998) J. Chromatogr. , vol.794 , pp. 299-316
    • Wolfender, J.-L.1    Rodriguez, S.2    Hostettmann, K.3
  • 43
    • 0000673856 scopus 로고
    • Resolution of discrete and continuous molecular size distributions by means of diffusion-ordered 2D NMR spectroscopy
    • Morris, K. F.; Johnson, C. S., Jr. Resolution of discrete and continuous molecular size distributions by means of diffusion-ordered 2D NMR spectroscopy. J. Am. Chem. Soc. 1993, 115, 4291-4299.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 4291-4299
    • Morris, K.F.1    Johnson C.S., Jr.2
  • 44
    • 0001002874 scopus 로고
    • High-resolution diffusion-ordered 2D spectroscopy (HR-DOSY) - A new tool for the analysis of complex mixtures
    • Barjat, H.; Morris, G. A.; Smart, S.; Swanson, A. G.; Williams, S. C. R. High-resolution diffusion-ordered 2D spectroscopy (HR-DOSY) - A new tool for the analysis of complex mixtures. J. Magn. Reson. B. 1995, 108, 170-172.
    • (1995) J. Magn. Reson. B. , vol.108 , pp. 170-172
    • Barjat, H.1    Morris, G.A.2    Smart, S.3    Swanson, A.G.4    Williams, S.C.R.5
  • 46
    • 0001448626 scopus 로고    scopus 로고
    • Mixture analysis in combinatorial chemistry. Application of diffusion-resolved NMR spectroscopy
    • Lin, M.; Shapiro, M. J. Mixture Analysis in Combinatorial Chemistry. Application of Diffusion-Resolved NMR Spectroscopy. J. Org. Chem. 1996, 61, 7617-7619.
    • (1996) J. Org. Chem. , vol.61 , pp. 7617-7619
    • Lin, M.1    Shapiro, M.J.2
  • 47
    • 0029836953 scopus 로고    scopus 로고
    • Discovering high-affinity ligands for proteins: SAR by NMR
    • Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.; Fesik, S. W. Discovering High-Affinity Ligands for Proteins: SAR by NMR. Science 1996, 274, 1531-1534.
    • (1996) Science , vol.274 , pp. 1531-1534
    • Shuker, S.B.1    Hajduk, P.J.2    Meadows, R.P.3    Fesik, S.W.4
  • 50


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