Cell growth inhibition by the multifunctional multivalent zinc-finger factor CTCF

Cancer Research

Volumn 61, Issue 16, 2001, Pages 6002-6007

  Rasko, John E J ^a   Klenova, Elena M ^b   Leon, Javier ^c   Filippova, Galina N ^d   Loukinov, Dmitri I ^e   Vatolin, Sergei ^e   Robinson, Abigail F ^b   Jia Hu, Ying ^d   Ulmer, Jonathan ^d   Ward, Michael D ^d   Pugacheva, Elena M ^e   Neiman, Paul E ^d   Morse, Herbert C ^e   Collins, Steven J ^d   Lobanenkov, Victor V ^e  

^a CENTENARY INSTITUTE   (Australia)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF CANTABRIA   (Spain)

^d Fred Hutchinson Cancer Research Center   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL CYCLE S PHASE; CELL DIVISION; CELL GROWTH; CLONOGENESIS; CONTROLLED STUDY; GENE ACTIVATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; TUMOR SUPPRESSOR GENE;

3T3 CELLS; ANIMALS; CELL DIVISION; CELL LINE; DNA REPLICATION; DNA-BINDING PROTEINS; GENES, MYC; GREEN FLUORESCENT PROTEINS; GROWTH INHIBITORS; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; MICE; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION; ZINC FINGERS;

EID: 0035881310     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. CTCF is a uniquely versalite transcriptional regulator with diverse functions linked to epigenetics and disease
2. Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF
3. Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF
4. Transcriptional repression by the insulator protein CTCF involves histone deacetylases
5. Functional association of CTCF with the insulator upstream of the H19 gene is a parent of origin-specific and methylation-sensitive
6. Igf2 imprinting in development and disease
7. Genomic imprinting and cancer
8. A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5′-flanking sequence of the chicken c-myc gene
9. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
10. A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers
11. Cancer epigenetics takes center stage
12. Definition of regions in human c-myc that are involved in transformation and nuclear localization
13. Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector
14. CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms
15. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination
16. Determination of lymphocyte division by flow cytometry
17. Reporters of gene expression: Autofluorescent proteins
18. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
19. The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos
20. Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene