Insights into the Transcriptional Regulation of Steroidogenic Enzymes and StAR

Reviews in Endocrine and Metabolic Disorders

Volumn 2, Issue 3, 2001, Pages 269-274

  Sewer, Marion B ^a   Waterman, Michael R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Multifactorial regulation; Signaling pathways; Steroidogenic acute regulatory protein; Steroidogenic enzymes; Transcription factors

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NUCLEAR PROTEIN; PHOSPHOPROTEIN; STEROID; STEROID MONOOXYGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL; BIOSYNTHESIS; GENETIC TRANSCRIPTION; GENETICS; HUMAN; PHYSIOLOGY; REVIEW;

ANIMALS; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; HUMANS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; STEROID HYDROXYLASES; STEROIDS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0035434596     PISSN: 13899155     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011516532335     Document Type: Article

References (51)

1. Simpson ER, Waterman MR. Regulation by ACTH of steroid hormone biosynthesis in the adrenal cortex. Can J Biochem 1983;61:692-707.
2. Garren LD, Ney RL, Davis WW. Studies on the role of protein synthesis in the regulation of corticosterone production by ACTH in vivo. Proc Natl Acad Sci USA 1965;53:1443-1450.
3. Krueger RJ, Orme-Johnson NR. Acute adrenocorticotropic hormone stimulation of adrenal corticosteroidogenesis. J Biol Chem 1983;258:10159-10167.
4. Clark BJ, Wells J, King SR, Stocco DM. The purification, cloning, and expression of a novel leutenizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem 1994;269:28314-28322.
5. Caron KM, Ikeda Y, Soo SC, Stocco DM, Parker KL, Clark BJ. Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein. Mol Endocrinol 1997;11:138-147.
6. Catt KJ, Carson MC, Hausdorff WP, Leach-Harper CM, Baukal AJ, Guillemette G, Balla T, Aguilera G. Angiostensin II receptors and mechanisms of action in adrenal glomerulosa cells, J Steroid Biochem 1987;27:915-927.
7. Bosmann HB, Hales KH, Li X, Liu Z Stocco DM, Hales DB. Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic acute regulatory (StAR) protein in Leydig cells. Endocrinology 1996;137:4522-4525.
8. Liu Z, Stocco DM. Heat shock-induced inhibition of acute steroidogenesis in MA-10 cells is associated with inhibition of the synthesis of the steroidogenic acute regulatory protein. Endocrinology 1997;138:2722-2728.
9. Brand C, Cherradi N, Defaye G, Chinn A, Chambaz EM, Feige JJ, Bailly S. Transforming growth factor betal decreases cholesterol supply to mitochondria via repression of steroidogenic acute regulatory protein expression. J Biol Chem 1998;273:6410-6416.
10. Mauduit C, Gasnier F, Rey C, Chauvin MA, Stocco DM, Louisot P, Benahmed M. Tumor necrosis factor-alpha inhibits leydig cell steroidogenesis through a decrease in steroidogenic acute regulatory protein expression. Endocrinology 1998;139:2863-2868.
11. Lin T, Hu J, Wang D, Stocco DM. Interferon-gamma inhibits the steroidogenic acute regulatory protein messenger ribonucleic acid expression and protein levels in primary cultures of rat Leydig cells. Endocrinology 1998;139:2217-2222.
12. Sugawara T, Holt JA, Kiriakidou M, Strauss III JF. Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene. Biochemistry 1996;35:9052-9059.
13. Sandhoff TW, Hales DB, Hales KH, McLean MP. Transcriptional regulation of the steroidogenic acute regulatory protein gene by steroidogenic factor 1. Endocrinology 1998;139:4820-4831.
14. LaVoie HA, Garmey JC, Veldhuis JD. Mechanisms of insulin-like growth factor 1 augmentation of follicle-stimulating hormone-induced procine steroidogenic acute regulatory protein gene promoter activity in granulosa cells. Endocrinology 1999;140:146-153.
15. Reinhart A, Williams S, Clark B, Stocco D. SF-1 and C/EBPb cooperate to regulate the murine StAR promoter. Mol Endocrinol 1999;13:729-741.
16. Rust W, Stedronsky K, Tillmann G, Morley S, Walther N, Ivell R. The role of Sf-1/Ad4BP in the control of the bovine gene for the steroidogenic acute regulatory (StAR) protein. J Mol Endocrinol 1998;21:189-200.
17. Clark BJ, Combs R. Angiotensin II and cyclic adenosine 3′,5′-monophosphate induce human steroidogenic acute regulatory protein transcription through a common steroidogenic factor-1 element. Endocrinology 1999;140:4390-4398.
18. Zazopoulos E, Lalli E, Stocco DM, Sassone-Corsi P. DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis. Nature 1997;390:311-315.
19. Jones PM, Sayed SB, Persaud SJ, Burns CJ, Gyles S, Whitehouse BJ. Cyclic AMP-induced expression of steroidogenic acute regulatory protein is dependent upon phosphoprtein phosphatase activities. J Mol Endocrinol 2000;24:233-239.
20. Waterman MR, Keeney DS. Diverse molecular mechanisms regulate the expression of steroid hydroxylase genes required for production of ligands for nuclear receptors. Advances in Mol and Cell Biol 1996;14:81-102.
21. Morohashi K, Honda S, Inomata Y, Handa H, Omura T. A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. J Biol Chem 1992;267:17913-17919.
22. Parker KL, Schimmer BP. Steroidogenic factor 1: A key determinant of endocrine development and function. Endocrine Revs 1997;18:361-377.
23. Le Goascogne C, Robel P, Gouezou M, Sananes N, Baulieu EE, Waterman M. Neurosteroids: Cytochrome P450scc in rat brain. Science 1987;237:1212-1215.
24. Vianello S, Waterman MR, Valle LD, Colombo L. Developmentally regulated expression and activity of 17a-hydroxylase/C-17,20-lyase cytochrome P450 in rat liver. Endocrinology 1997;138:3166-3174.
25. Lala DS, Syka PM, Lazarchik SB, Mangelsdorf DJ, Parker KL, Heyman RA. Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. Proc Natl Acad Sci USA 1997;94:4895-4900.
26. Chrestenson LK, McAllister JM, Martin KO, Javitt NB, Osborne TF, Strauss JF III. Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. J Biol Chem 1998;273:30729-30735.
27. Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: Integration of hormone signaling in reproduction and stress. Mol Cell 1999;3:521-526.
28. Vossler MR, Yao H, York RD Pan MG, Rim CS, Stork PJ. cAMP activates MAP kinase and Elk-1 through a B-raf and rap1-dependent pathway. Cell 1997;89:73-82.
29. Ito M, Yu RN, Jameson JL. Steroidogenic factor-1 contains a carboxy-terminal transcriptional activation domain that interacts with steroid receptor coactivator-1. Mol Endocrinol 1998;12:290-301.
30. Monte D, De Witte F, Hum DW. Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300. J Biol Chem 1998;273:4585-4591.
31. Wang X-L, Basett M, Zhang Y, Yin S, Clyne C, White PC, and Rainey WE. Transcriptional regulation of human 11beta-hydroxylase (hCYP11B1). Endocrinology 2000;141:3587-3594.
32. Sadovsky Y, Crawford PA, Woodson KG, Polish JA, Clements MA, Tourtellotte LM, Simburger K, Milbrandt J. Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci USA 1995;92:10939-10943.
33. Luo X, Ikeda Y, Parker KL. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 1994;77:481-490.
34. Roesler WJ, Vandenbar GR, Hanson RW Cyclic AMP and the induction of eukaryotic gene transcription. J Biol Chem 1988;263:9063-9066.
35. Viard I, Hall SH, Jaillard C, Berthelon MC, Saez JM. Regulation of c-fos, c-jun and jun-b messenger ribonucleic acids by angiotensin-II and corticotropin in ovine and bovine adrenocortical cells. Endocrinology 1992;130:1193-1200.
36. John ME, John MC, Boggaram V, Simpson ER, Waterman MR. Transcriptional regulation of steroid hydroxylase genes by ACTH. Proc Natl Acad Sci USA 1986;83:4715-4719.
37. Waterman MR. Biochemical diversity of cAMP-Dependent transcription of steroid hydroxylase genes in the adrenal cortex. J Biol Chem 1994;269:27783-27786.
38. Rice DA, Aitken LD, Vandenbark GR, Mouw AR, Franklin A, Schimmer BP, Parker KL. A cAMP-responsive element regulates expression of the mouse steroid 11 beta-hydroxylase gene. J Biol Chem 1989;264:14011-14015.
39. Kagawa N, Waterman MR. Purification and characterization of a transcription factor which appears to regulate cAMP responsive- ness of the human CYP21B gene. J Biol Chem 1992;267:25213-25219.
40. Bischof LJ, Kagawa N, Moskow JJ, Takahashi Y, Iwamatsu A, Buchberg AM, Waterman MR. Members of the Meis1 and Pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. J Biol Chem 1998;273:7941-7948.
41. Ahlgren R, Suske G, Waterman MR, Lund J. Role of Sp1 in cAMP-dependent transcriptional regulation of the bovine CYP11A gene. J Biol Chem 1999;274:19422-19428.
42. Orava M, Voutilainen R, Vihko R. Interferon-γ inhibits steroidogenesis and accumulation of mRNA of the steroidogenic enzymes P450scc and P450c17 in cultured porcine leydig cells. Mol Endocrinol 1989;3:887-894.
43. 2+-regulated expression of 21-hydroxylase cytochrome P450 in H295R human adrenocortical cells. J Clin Endocrinol Metab 1998;83:1592-1597.
44. Ilvesmäki V, Voutilainen R. Interaction of phorbol ester and adrenocorticotropin in the regulation of steroidogenic P450 genes in human fetal and adult adrenal cell cultures. Endocrinology 1991;128:1450-1458.
45. Leers-Sucheta S, Morohashi K, Mason JI, Melner MH. Synergistic activation of the human type II 3β-hydroxysteroid dehydrogenase/ 5-4 isomerase promoter by the transcription factor steroidogenic factor-I/adrenal 4-binding protein and phorbol ester. J Biol Chem 1997;272:7960-7967.
46. Pestell RG, Albanese C, Watanabe G, Johnson J, Eklund N, Lastowiecki P, Jameson JL. Epidermal growth factor and c-jun act via a common DNA regulatory element to stimulate transcription of the ovine P-450 cholesterol side chain cleavage (CYP11A1) promoter. J Biol Chem 1995;270:18301-18308.
47. Bannister AJ, Kouzarides T. The CBP co-activator is a histone acetyltransferase. Nature 1996;384:641-643.
48. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 1997;389:194-198.
49. Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev 1998;12:599-606.
50. Shibata H, Ando T, Kurihara I, Suzuki T, Lund J, Morohashi K, Sasano H, Hayashi K, Hayashi M, Saito I, Saruta T. Functional role of COUP-TF1, SF-1 and nuclear receptor coregulators in the steroidogenesis of adrenocortical adenomas. In: Okamoto M, Ishimura Y, Nawata H, eds. Molecular Steroidogenesis. Japan: Universal Academy Press, 2000;345-348.
51. Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S. PNRC: A proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRα1 (estrogen related receptor α-1). Mol Endocrinol 2000;14:986-998.