Interferon-γ inhibits the steroidogenic acute regulatory protein messenger ribonucleic acid expression and protein levels in primary cultures of rat Leydig cells

Endocrinology

Volumn 139, Issue 5, 1998, Pages 2217-2222

  Lin, Tu ^a   Hu, Jianxin ^a   Wang, Deli ^a   Stocco, Douglas M ^b  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CHORIONIC GONADOTROPIN; GAMMA INTERFERON; MESSENGER RNA; PREGNENOLONE; RECOMBINANT INTERLEUKIN 1BETA; REGULATOR PROTEIN; RIBONUCLEASE; STEROID HORMONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; LEYDIG CELL; MALE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STEROIDOGENESIS;

EID: 0031765097     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.5.6006     Document Type: Article

References (49)

1. Kalvakolanu DV, Borden EC 1996 An overview of the interferon system: signal transduction and mechanism of action. Cancer Invest 14:25-53
2. Natwar RK, Mann A, Sharma RK, Aulitzky W, Frick J 1995 Effect of human gamma interferon on mice testis: a quantitative analysis of the spermatogenic cells. Acta Eur Fertil 26:45-49
3. Bussiere JL, Hardy LM, Hoberman AM, Foss JA, Christian MS 1996 Reproductive effects of chronic administration of murine interferon-γ. Reprod Toxicol 10:379-391
4. Hekman ACP, Trapman J, Mulder A, van Gaalen JLM, Zwarhoff EC 1988 Interferon expression in the testes of transgenic mice leads to sterility. J Biol Chem 263:12151-12155
5. Iwakura Y, Asano M, Nishimune Y, Kawade Y 1988 Male sterility of transgenic mice carrying exogenous mouse interferon-β gene under the control of the metallothionein enhancer-promoter. EMBO J 7:3757-3762
6. Orava M, Cantell K, Vihko R 1985 Treatment with preparations of human leukocyte interferon decreases serum testosterone concentrations in men. Int J Cancer 38:295-296
7. Orava M, Cantell K, Vihko R 1985 Human leukocyte interferon inhibits human chorionic gonadotropin stimulated testosterone production by porcine Leydig cells in culture. Biochem Biophys Res Commun 127:809-815
8. Orava M, Voutilainen R, Vihko R 1989 Interferon-γ inhibits steroidogenesis and accumulation of mRNA of the steroidogenic enzymes P450scc and P450c17 in cultured porcine Leydig cells. Mol Endocrinol 3:887-894
9. Meikle AW, Cardoso de Sousa JC, Dacosta N, Bishop DK, Samlowski WE 1992 Direct and indirect effects of murine interleukin-2, γ interferon, and tumor necrosis factor on testosterone synthesis in mouse Leydig cells. J Androl 13:437-443
10. Miller WL 1988 Molecular biology of steroid hormone synthesis. Endocr Rev 9:295-318
11. Ferguson JJ 1963 Protein synthesis and adrenocorticotropin responsiveness. J Biol Chem 238:2754-2759
12. Garren LD, Nay RL, Davis WW 1965 Studies on the role of protein synthesis in the regulation of corticosterone production by ACTH in vivo. Proc Natl Acad Sci USA 53:1443-1450
13. Davis WW, Garren LD 1968 On the mechanism of action of adrenocorticotropic hormone the inhibitory site of cycloheximide in the pathway of steroid biosynthesis. J Biol Chem 243:5153-5157
14. Vahouny GV, Chanderbhan R, Kharroubi A, Noland BJ, Pastuszyn A, Scallen TJ 1987 Sterol carrier and lipid transfer proteins. Adv Lipid Res 22:83-113
15. Pederson RC, Brownie AC 1983 Cholesterol side-chain cleavage in the rat adrenal cortex: isolation of a cycloheximide-sensitive activator protein. Proc Natl Acad Sci USA 80:1882-1886
16. Papadopoulos V 1989 Peripheral type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev 14:222-240
17. Clark BJ, Wells J, King SR, Stocco DM 1994 The purification, cloning and the expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. J Biol Chem 269:28314-28322
18. Stocco DM, Clark BJ 1996 Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17:221-244
19. Clark BJ, Soo SC, Caron KM, Ikeda Y, Parker KL, Stocco DM 1995 Hormonal and developmental regulation of the steroidogenic acute regulatory protein. Mol Endocrinol 9:1346-1355
20. Sugawara T, Holt JA, Driscoll D, Strauss III JF, Lin D, Miller WL, Patterson D, Clancy KP, Hart IM, Clark BJ, Stocco DM 1995 Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.1 and a pseuodgene to chromosome 13. Proc Natl Acad Sci USA 92:4778-4782
21. Lin D, Sugawara T, Strauss III JF, Clark BJ, Stocco DM, Saenger P, Rogol A, Miller WL 1995 Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267:1828-1831
22. Tee MK, Lin D, Sugawara T, Holt JA, Guigen Y, Buckingham B, Strauss III JF, Miller WL 1995 T A transversion 11 bp from a splice acceptor site in the gene for steroidogenic acute regulatory protein causes congenital lipoid adrenal hyperplasia. Hum Mol Genet 4:2229-2305
23. Bose HS, Sugawara T, Strauss III JA, Miller WL 1996 The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. N Engl J Med 335:1870-1878
24. Klinefelter GR, Hall PF, Ewing LL 1987 Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multi-step procedure. Biol Reprod 36:769-783
25. Lin T, Wang D, Calkins JH, Guo H, Chi R, Hausley PR 1990 Regulation of insulin-like growth factor-I messenger ribonucleic acid expression in Leydig cells. Mol Cell Endocrinol 73:147-152
26. Payne AH, Downing JR, Wong KL 1980 Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 106:1424-1429
27. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
28. Lin T, Wang D, Nagpal ML, Calkins JH, Chang W, Chi R 1991 Interleukin-1 inhibits cholesterol side-chain cleavage cytochrome P450 expression in primary cultures of Leydig cells. Endocrinology 129:1305-1311
29. Wang D, Nagpal ML, Lin T, Shimasaki S, Ling N 1994 Insulin-like growth factor-binding protein-2: the effect of human chorionic gonadotropin on its gene regulation and protein secretion and its biological effects in rat Leydig cells. Mol Endocrinol 8:69-76
30. Calkins, JH, Sigel MM, Nankin HR, Lin T 1988 Interleukin-1 inhibits Leydig cell steroidogenesis in primary culture. Endocrinology 123:1605-1610
31. Verhoeven G, Cailleau J, Damme JV, Billiau A 1988 Interleukin-1 stimulates steroidogenesis in cultured rat Leydig cells. Mol Cell Endocrinol 57:51-60
32. Hales DB 1992 Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17α-hydroxylase/C17-20 lyase cytochrome P450 expression. Endocrinology 131:2165-2172
33. Mauduit C, Hartman DJ, Chauvin MA, Revol A, Morera AM, Benahmed M 1991 Tumor necrosis factor-α inhibits gonadotropin action in cultured porcine Leydig cells: site(s) of action. Endocrinology 129:2933-2940
34. Xiong Y, Hales DB 1993 The role of tumor necrosis factor-α in the regulation of mouse Leydig cell steroidogenesis. Endocrinology 132:2438-2444
35. Lin T, Wang D, Nagpal ML, Chang W 1994 Recombinant murine tumor necrosis factor-α inhibits cholesterol side-chain cleavage cytochrome P450 and insulin-like growth factor-I gene expression in rat Leydig cells. Mol Cell Endocrinol 101:111-119
36. Dejucq N, Dugast I, Ruffault AM, van der Meide PH, Jegou B 1995 Interferon-α and -γ expression in the rat testis. Endocrinology 136:4925-4931
37. Bessler H, Singer R, Raanani P, Levinsky H, Lahav M, Cohen AM 1995 Interferon α-2b modulates β-galactoside α-2,6-sialytransferase gene expression in rat testes. Biol Reprod 53:1474-1477
38. Eddy EM 1988 The spermatozoon. In: Knobil E, Neil J (eds) The Physiology of Reproduction. Raven Press, New York, pp 27-102
39. Hammerstedt RH, Parks JE 1987 Changes in sperm surface associated with epididymal transit. J Reprod Fertil [Suppl] 34:133-149
40. Morrison DC, Ryan JL 1987 Endotoxins and disease mechanisms. Annu Rev Med 38:417-432
41. Bosmann HB, Hales KH, Li X, Liu Z, Stocco DM, Hales DB 1996 Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic acute regulatory (StAR) protein in Leydig cells. Endocrinology 137:4522-4525
42. Darnell Jr JE 1997 STATs, and gene regulation. Science 277:1630-1635
43. Kanzaki M, Morris PL, Expression and regulation of interferon-γ receptor in rat testis. 14th Testis Workshop: Germ Cell Development, Division, Disruption, and Death, Baltimore, MD, 1997 (Abstract I-38)
44. Jenab S, Morris PL 1996 Differential activation of signal transducer and activator of transcription (STAT)-3 and STAT-1 transcription factors and c-fos messenger ribonucleic acid by interleukin-6 and interferon-γ in Sertoli cells. Endocrinology 137:4738-4743
45. Jenab S, Morris PL 1997 Transcriptional regulation of Sertoli cell immediate early genes by interleukin-6 and interferon-γ is mediated through phosphorylarion of STAT-3 and STAT-1 proteins. Endocrinology 138:2740-2746
46. Handelsman DJ 1994 Testicular dysfunction in systemic disease. Endocrinol Metab Clin North Am 23:839-856
47. Sharpe RM 1994 Regulation of spermatogenesis. In: Knobil E, Neill JD (eds) The Physiology of Reproduction. Raven Press, New York, pp 1363-1434
48. Chen J, Chandrashekar V, Zirkin BR 1994 Can spermatogenesis be maintained quantitatively in intact adult rats with exogenously administered dihydrotestosterone? J Androl 15:132-138
49. Saez JM 1994 Leydig cells: endocrine, paracrine and autocrine regulation. Endocr Rev 15:574-628