Chlorpromazine modulates cytokine expression in the liver and lung after burn injury and endotoxemia

Journal of Trauma - Injury, Infection and Critical Care

Volumn 48, Issue 2, 2000, Pages 215-223

  Clancy, Keith D ^a   Lorenz, Kathryn ^a   Dries, David ^a   Gamelli, Richard L ^a   Hahn, Elisabeth L ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Burn injury; Chlorpromazine; MIP 1 ; Sepsis; TNF

Indexed keywords

CHLORPROMAZINE; ESCHERICHIA COLI ENTEROTOXIN; INTERLEUKIN 10; MACROPHAGE INFLAMMATORY PROTEIN 1; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BURN; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; LIVER; LUNG; MALE; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; SEPSIS;

EID: 0034002283     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005373-200002000-00003     Document Type: Conference Paper

References (24)

1. Gamelli RL, Hebert JC, Foster RS. Effect of burn injury on granulocyte and macrophage production. J Trauma. 1985; 25:615-619.
2. Marano MA, Fong Y, Moldawer LL, et al. Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality. Surg Gynecol Obstet. 1990;170:32-38.
3. Minei J, Williams JG, Hill SJ, et al. Augmented tumor necrosis factor response to lipopolysaccharide after thermal injury is regulated posttranscriptionally. Arch Surg. 1994; 129:1198-1203.
4. Marshall WG, Dimick AR. The natural history of major burns with multiple subsystem failure. J Trauma. 1983; 23:102-105.
5. Molloy RG, O'Riordan M, Holzheimer R, et al. Mechanism of increased tumor necrosis factor production after thermal injury. J Immunol. 1993;151:2142-2149.
6. Svoboda P, Kantorova I, Ochmann J. Dynamics of interleukin 1, 2, and 6 and tumor necrosis factor alpha in multiple trauma patients. J Trauma. 1994;36:336-340.
7. Remick DG, Strieter RM, Lynch JP III, et al. In vivo dynamics of murine tumor necrosis factor-α gene expression: kinetics of dexamethasone-induced suppression. Lab Invest. 60:766-771.
8. Ertel W, Morrison MH, Wang P, et al. The complex pattern of cytokines in sepsis: association between prostaglandins, cachectin, and interleukins. Ann Surg. 1991;214:141-148.
9. Fisher CJ, Opal SM, Dhainaut JF, et al. Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. Crit Care Med. 1993;21:318-327.
10. Fahmi H, Chaby R. Selective refractoriness of macrophages to endotoxin-induced production of tumor necrosis factor, elicited by an autocrine mechanism. J Leukoc Biol. 1993; 53:45-52.
11. Deitch EA. Multiple organ failure: pathophysiology and potential future therapy. Ann Surg. 1992;216:117-134.
12. Clancy K, Lorenz K, Hahn E, et al. Down regulation of tissue specific TNF-α in the liver and lung after burn injury and endotoxemia. J Trauma. 1997;42:169-176.
13. Gadina M, Bertini R, Mengozzi M, et al. Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid resistant models of endotoxic shock. J Exp Med. 1991;173:1305-1310.
14. Donnelly R, Freeman S, Hayes M. Inhibition of IL-10 expression by IFN-γ up-regulates transcription of TNF-α in human monocytes. J Immunol. 1995;155:1420-1427.
15. Tarazona R, Gonzalez-Garcia A, Zamzami N, et al. Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo. J Immunol. 1995;154:861-870.
16. Spector WS, ed. Handbook of Biological Data. Philadelphia: Saunders; 1956.
17. Hofmann CA, Lorenz K, Braithwaite SS, et al. Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 1994;134:264-270.
18. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
19. Fourney RM, Miyashi J, Day RS. Northern blotting: efficient RNA staining and transfer. FOCUS. 1988;10:5-7.
20. Ghezzi P, Garattini S, Mennini T, et al. Mechanism of inhibition of tumor necrosis factor production by chlorpromazine and its derivatives in mice. Eur J Pharmacol. 1996;317:369-376.
21. Jansen MJ, Hendriks T, Knapen MF, van Kempen LC, van der Meer JW, Goris RJ. Chlorpromazine down-regulates tumor necrosis factor a and attenuates experimental multiple organ failure dysfunction syndrome in mice. Crit Care Med. 1998;26:1244-1250.
22. Shanley T, Schmal H, Friedl H, et al. Role of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in acute lung injury in rats. J Immunol. 1995;154:4793-4802.
23. Czermak BJ, Friedl HP, Ward PA. Complement, cytokines, and adhesion molecule expression in inflammatory reactions. Proc Assoc Am Physicians. 1998;110:306-312.
24. Bleeker M, Neta B, Kullberg J, van der Ven-Jongekrijg, Van der Meer. The effects of dexamethasone and chlorpromazine on tumor necrosis factor and interleukin 1, interleukin 1 receptor antagonist and interleukin 10 production in human volunteers. Immunology 1997;91:548-552.