Mapping extracellular pH in rat brain gliomas in Vivo by 1H magnetic resonance spectroscopic imaging: Comparison with maps of metabolites

Cancer Research

Volumn 61, Issue 17, 2001, Pages 6524-6531

  García Martín, María L ^a   Hérigualt, Gwénaël ^b   Rémy, Chantal ^b   Farion, Régine ^b   Ballesteros, Paloma ^c   Coles, Jonathan A ^b   Cerdán, Sebastián ^a   Ziegler, Anne ^b  

^a CSIC   (Spain)

^b UNIV GRENOBLE ALPES   (France)

^c UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 IMIDAZOL 1 YL 3 ETHOXYCARBONYLPROPIONIC ACID; CHOLINE DERIVATIVE; CREATINE PHOSPHATE; GADOTERIC ACID; LACTIC ACID DERIVATIVE; N ACETYLASPARTIC ACID; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN MAPPING; CAUDATE NUCLEUS; CELL PH; CELL VIABILITY; CONTROLLED STUDY; DIAGNOSTIC VALUE; GLIOMA; IMAGE ANALYSIS; IN VIVO STUDY; INTERMETHOD COMPARISON; JUGULAR VEIN; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TUMOR CELL;

ANIMALS; ASPARTIC ACID; BRAIN NEOPLASMS; BUFFERS; CHOLINE; CONTRAST MEDIA; CREATINE; EXTRACELLULAR SPACE; FEMALE; GLIOMA; HETEROCYCLIC COMPOUNDS; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; ORGANOMETALLIC COMPOUNDS; PHOSPHOCREATINE; PROPIONIC ACIDS; PROTONS; RATS; RATS, WISTAR;

EID: 0035420015     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. The relevance of tumor pH to the treatment of malignant disease
2. pH distributions in spontaneous and isotransplanted rat tumours
3. Causes and consequences of acidic pH in tumors: A magnetic resonance study
4. Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
5. The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-ph-adapted cells
6. 31P probes
7. Enhancement of chemotherapy by manipulation of tumour pH
8. Tumor extracellular pH as a prognostic factor in thermoradiotherapy
9. Die Wasserstoffionenkonzentration des Hirngewebes bei raumfordernden intracraniellen Prozessen
10. pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes
11. Simultaneous evaluation of the effects of RF hyperthermia on the intra- and extracellular tumor pH
12. 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate
13. 31P magnetic resonance spectroscopy in murine tumours
14. Measurement of intratumor pH by pH indicator used in 19F-magnetic resonance spectroscopy. Measurement of extracellular pH decrease caused by hyperthermia combined with hydralazine
15. 2 gradients in solid tumors in vivo: High resolution measurements reveal a lack of correlation
16. 1H NMR probes for the determination of intracellular pH, extracellular pH and cell volume
17. In vivo imaging of extracellular pH using I H MRSI
18. 1H magnetic resonance spectroscopic imaging of extracellular pH in an intracerebral glioma
19. 13C] D-glucose
20. Versuche an überiebendem Carcinomgewebe
21. Lactate turnover in rat glioma measured by in vivo nuclear magnetic resonance spectroscopy
22. The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
23. The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase
24. Studies with glycolysisdeficient cells suggest that production of lactic acid is not the only cause of tumor acidity
25. Hard-pulse sequences for solvent suppression which only need a zero-order phase correction
26. Differentiated rat glial cell strain in tissue culture
27. An improved rat brain-tumor model
28. Use of T(2)-weighted susceptibility contrast MRI for mapping the blood volume in the glioma-bearing rat brain
29. Spatial localization in NMR spectroscopy in vivo
30. 1H NMR chemical shift selective (CHESS) imaging
31. Solvent-peak-suppressed, NMR correction of baseline distortions and use of a strong-pulse excitation
32. Solvent suppression in fourier transform nuclear magnetic resonance
33. Optimizing spatially localized NMR
34. Proton NMR chemical shifts and coupling constants for brain metabolites
35. Timedependent changes in image contrast in brain tumors after gadolinium-DTPA
36. 1H magnetic resonance imaging of gadolinium uptake
37. Buffer-facilitated proton transport pH profile of bound enzymes
38. + transport in the interstitial fluid
39. Evidence for rotational contribution to protein-facilitated proton transport
40. Vivo time-resolved brain phosphorus nuclear magnetic resonance
41. Proton magnetic resonance spectroscopy reflects cellular proliferative activity in astrocytomas
42. 1H NMR spectroscopic imaging
43. Relationships among lactate concentration, blood flow and histopathologic profiles in rat C6 glioma
44. Shaking up glycolysis: Sustained, high lactate flux during aerobic rattling
45. Lactate is released and taken up by isolated rabbit vagus nerve during aerobic metabolism
46. 1H NMR study
47. Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT 1 and demonstrates that glycosylation is not required for MCT1 function
48. Experimental displacement of intracellular pH and the mechanism of its subsequent recovery
49. Hyperlactatemia and lacticacidosis